3F75

Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3f75a_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	automated matches	automated matches	(Toxoplasma gondii RH ) [TaxId: 383379 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Papain-like	8066296	4000859	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Cysteine proteinases	8066297	3001808	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Peptidase_C1	e3f75A1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: Peptidase_C1	ECOD (1.6)
B [auth P]	Inhibitor_I29	e3f75P1	A: alpha arrays	X: Peptidase inhibitors family I29 (From Topology)	H: Peptidase inhibitors family I29 (From Topology)	T: Peptidase inhibitors family I29	F: Inhibitor_I29	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.70.10	Alpha Beta	Alpha-Beta Complex	Cathepsin B	Chain A	CATH (4.3.0)
B [auth P]	1.10.287.2250	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00112	Papain family cysteine protease (Peptidase_C1)	Papain family cysteine protease	-	Domain
B [auth P]	PF08246	Cathepsin propeptide inhibitor domain (I29) (Inhibitor_I29)	Cathepsin propeptide inhibitor domain (I29)	This domain is found at the N-terminus of some C1 peptidases such as Cathepsin L where it acts as a propeptide. There are also a number of proteins that are composed solely of multiple copies of this domain such as the peptidase inhibitor salarin Sw ...	This domain is found at the N-terminus of some C1 peptidases such as Cathepsin L where it acts as a propeptide. There are also a number of proteins that are composed solely of multiple copies of this domain such as the peptidase inhibitor salarin Swiss:Q70SU8. This family is classified as I29 by MEROPS.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cathepsin L Protease	cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	membrane cellular anatomical entity
B [auth P]	Cathepsin L Propeptide	cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
A	IPR025661	Cysteine peptidase, asparagine active site	Active Site
A	IPR000169	Cysteine peptidase, cysteine active site	Active Site
A	IPR025660	Cysteine peptidase, histidine active site	Active Site
A	IPR013128	Peptidase C1A	Family
A	IPR000668	Peptidase C1A, papain C-terminal	Domain
A	IPR013201	Cathepsin propeptide inhibitor domain (I29)	Domain
A	IPR039417	Papain-like cysteine endopeptidase	Domain
B [auth P]	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
B [auth P]	IPR025661	Cysteine peptidase, asparagine active site	Active Site
B [auth P]	IPR000169	Cysteine peptidase, cysteine active site	Active Site
B [auth P]	IPR025660	Cysteine peptidase, histidine active site	Active Site
B [auth P]	IPR013128	Peptidase C1A	Family
B [auth P]	IPR000668	Peptidase C1A, papain C-terminal	Domain
B [auth P]	IPR013201	Cathepsin propeptide inhibitor domain (I29)	Domain
B [auth P]	IPR039417	Papain-like cysteine endopeptidase	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.