3EVX

Crystal structure of the human E2-like ubiquitin-fold modifier conjugating enzyme 1 (Ufc1). Northeast Structural Genomics Consortium target HR41

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3evxa_	Alpha and beta proteins (a+b)	UBC-like	UBC-like	UFC1-like	Ufm1-conjugating enzyme 1, UFC1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3evxb_	Alpha and beta proteins (a+b)	UBC-like	UBC-like	UFC1-like	Ufm1-conjugating enzyme 1, UFC1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3evxc_	Alpha and beta proteins (a+b)	UBC-like	UBC-like	UFC1-like	Ufm1-conjugating enzyme 1, UFC1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3evxd_	Alpha and beta proteins (a+b)	UBC-like	UBC-like	UFC1-like	Ufm1-conjugating enzyme 1, UFC1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	UFC1-like	8030422	4003426	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	UBC-like	8042801	3000570	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	UBC-like	8042801	3000570	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	UBC-like	8042801	3000570	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	UBC-like	8042801	3000570	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08694	e3evxA1	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: PF08694	ECOD (1.6)
B	PF08694	e3evxB1	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: PF08694	ECOD (1.6)
C	PF08694	e3evxC1	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: PF08694	ECOD (1.6)
D	PF08694	e3evxD1	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: PF08694	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.110.10	Alpha Beta	Roll	Ubiquitin Conjugating Enzyme	Ubiquitin Conjugating Enzyme	CATH (4.3.0)
B	3.10.110.10	Alpha Beta	Roll	Ubiquitin Conjugating Enzyme	Ubiquitin Conjugating Enzyme	CATH (4.3.0)
C	3.10.110.10	Alpha Beta	Roll	Ubiquitin Conjugating Enzyme	Ubiquitin Conjugating Enzyme	CATH (4.3.0)
D	3.10.110.10	Alpha Beta	Roll	Ubiquitin Conjugating Enzyme	Ubiquitin Conjugating Enzyme	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF08694	Ubiquitin-fold modifier-conjugating enzyme 1 (UFC1)	Ubiquitin-fold modifier-conjugating enzyme 1	Ubiquitin-like (UBL) post-translational modifiers are covalently linked to most, if not all, target protein(s) through an enzymatic cascade analogous to ubiquitylation, consisting of E1 (activating), E2 (conjugating), and E3 (ligating) enzymes. Ubiqu ...	Ubiquitin-like (UBL) post-translational modifiers are covalently linked to most, if not all, target protein(s) through an enzymatic cascade analogous to ubiquitylation, consisting of E1 (activating), E2 (conjugating), and E3 (ligating) enzymes. Ubiquitin-fold modifier 1 (Ufm1) a ubiquitin-like protein is activated by a novel E1-like enzyme, Uba5, by forming a high-energy thioester bond. Activated Ufm1 is then transferred to its cognate E2-like enzyme, Ufc1, in a similar thioester linkage. This family represents the E2-like enzyme.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Ufm1-conjugating enzyme 1	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity UFM1 transferase activity transferase activity catalytic activity UFM1 conjugating enzyme activity ubiquitin-like protein conjugating enzyme activity	developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development organonitrogen compound metabolic process primary metabolic process protein ufmylation organic substance metabolic process developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development organonitrogen compound metabolic process primary metabolic process protein ufmylation organic substance metabolic process macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cellular component disassembly catabolic process macroautophagy cellular metabolic process autophagy cellular component organization cellular catabolic process organelle organization organelle disassembly reticulophagy cellular process cellular component organization or biogenesis process utilizing autophagic mechanism cellular response to stimulus cellular response to stress response to stimulus response to stress response to endoplasmic reticulum stress protein polyufmylation protein K69-linked ufmylation	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR016135	Ubiquitin-conjugating enzyme/RWD-like	Homologous Superfamily
A, B, C, D	IPR014806	Ubiquitin-fold modifier-conjugating enzyme 1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q9Y3C8	allergic rhinitis ovarian cancer diabetes mellitus plasma cell myeloma lymphoplasmacytic lymphoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.