3EUB

Crystal Structure of Desulfo-Xanthine Oxidase with Xanthine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3euba2	All alpha proteins	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
A	d3euba1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	2Fe-2S ferredoxin domains from multidomain proteins	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
D [auth J]	d3eubj2	All alpha proteins	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
D [auth J]	d3eubj1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	2Fe-2S ferredoxin domains from multidomain proteins	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
G [auth S]	d3eubs2	All alpha proteins	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
G [auth S]	d3eubs1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	2Fe-2S ferredoxin domains from multidomain proteins	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
J [auth 2]	d3eub22	All alpha proteins	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
J [auth 2]	d3eub21	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	2Fe-2S ferredoxin domains from multidomain proteins	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d3eubb2	Alpha and beta proteins (a+b)	CO dehydrogenase flavoprotein C-domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	automated matches	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d3eubb1	Alpha and beta proteins (a+b)	FAD-binding/transporter-associated domain-like	FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein N-terminal domain-like	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
E [auth K]	d3eubk2	Alpha and beta proteins (a+b)	CO dehydrogenase flavoprotein C-domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	automated matches	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
E [auth K]	d3eubk1	Alpha and beta proteins (a+b)	FAD-binding/transporter-associated domain-like	FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein N-terminal domain-like	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
H [auth T]	d3eubt2	Alpha and beta proteins (a+b)	CO dehydrogenase flavoprotein C-domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	automated matches	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
H [auth T]	d3eubt1	Alpha and beta proteins (a+b)	FAD-binding/transporter-associated domain-like	FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein N-terminal domain-like	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
K [auth 3]	d3eub32	Alpha and beta proteins (a+b)	CO dehydrogenase flavoprotein C-domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	automated matches	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
K [auth 3]	d3eub31	Alpha and beta proteins (a+b)	FAD-binding/transporter-associated domain-like	FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein N-terminal domain-like	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d3eubc1	Alpha and beta proteins (a+b)	alpha/beta-Hammerhead	CO dehydrogenase molybdoprotein N-domain-like	automated matches	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d3eubc2	Alpha and beta proteins (a+b)	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
F [auth L]	d3eubl1	Alpha and beta proteins (a+b)	alpha/beta-Hammerhead	CO dehydrogenase molybdoprotein N-domain-like	automated matches	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
F [auth L]	d3eubl2	Alpha and beta proteins (a+b)	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
I [auth U]	d3eubu1	Alpha and beta proteins (a+b)	alpha/beta-Hammerhead	CO dehydrogenase molybdoprotein N-domain-like	automated matches	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
I [auth U]	d3eubu2	Alpha and beta proteins (a+b)	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
L [auth 4]	d3eub41	Alpha and beta proteins (a+b)	alpha/beta-Hammerhead	CO dehydrogenase molybdoprotein N-domain-like	automated matches	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
L [auth 4]	d3eub42	Alpha and beta proteins (a+b)	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	automated matches	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	CO dehydrogenase ISP C-domain like	8043057	3000439	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	2Fe-2S ferredoxin-like	8043058	3000113	SCOP2B (2022-06-29)
D [auth J]	SCOP2B Superfamily	CO dehydrogenase ISP C-domain like	8043057	3000439	SCOP2B (2022-06-29)
D [auth J]	SCOP2B Superfamily	2Fe-2S ferredoxin-like	8043058	3000113	SCOP2B (2022-06-29)
G [auth S]	SCOP2B Superfamily	2Fe-2S ferredoxin-like	8043058	3000113	SCOP2B (2022-06-29)
G [auth S]	SCOP2B Superfamily	CO dehydrogenase ISP C-domain like	8043057	3000439	SCOP2B (2022-06-29)
J [auth 2]	SCOP2B Superfamily	2Fe-2S ferredoxin-like	8043058	3000113	SCOP2B (2022-06-29)
J [auth 2]	SCOP2B Superfamily	CO dehydrogenase ISP C-domain like	8043057	3000439	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	FAD-binding/transporter-associated domain-like	8043065	3000913	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	CO dehydrogenase flavoprotein C-terminal domain-like	8043061	3001921	SCOP2B (2022-06-29)
E [auth K]	SCOP2B Superfamily	FAD-binding/transporter-associated domain-like	8043065	3000913	SCOP2B (2022-06-29)
E [auth K]	SCOP2B Superfamily	CO dehydrogenase flavoprotein C-terminal domain-like	8043061	3001921	SCOP2B (2022-06-29)
H [auth T]	SCOP2B Superfamily	FAD-binding/transporter-associated domain-like	8043065	3000913	SCOP2B (2022-06-29)
H [auth T]	SCOP2B Superfamily	CO dehydrogenase flavoprotein C-terminal domain-like	8043061	3001921	SCOP2B (2022-06-29)
K [auth 3]	SCOP2B Superfamily	FAD-binding/transporter-associated domain-like	8043065	3000913	SCOP2B (2022-06-29)
K [auth 3]	SCOP2B Superfamily	CO dehydrogenase flavoprotein C-terminal domain-like	8043061	3001921	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Molybdenum cofactor-binding domain	8043062	3000625	SCOP2B (2022-06-29)
F [auth L]	SCOP2B Superfamily	Molybdenum cofactor-binding domain	8043062	3000625	SCOP2B (2022-06-29)
I [auth U]	SCOP2B Superfamily	Molybdenum cofactor-binding domain	8043062	3000625	SCOP2B (2022-06-29)
L [auth 4]	SCOP2B Superfamily	Molybdenum cofactor-binding domain	8043062	3000625	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Fer2_2	e3eubA1	A: alpha bundles	X: CO dehydrogenase ISP C-domain like (From Topology)	H: CO dehydrogenase ISP C-domain like (From Topology)	T: CO dehydrogenase ISP C-domain like	F: Fer2_2	ECOD (1.6)
A	Fer2	e3eubA2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2	ECOD (1.6)
D [auth J]	Fer2_2	e3eubJ1	A: alpha bundles	X: CO dehydrogenase ISP C-domain like (From Topology)	H: CO dehydrogenase ISP C-domain like (From Topology)	T: CO dehydrogenase ISP C-domain like	F: Fer2_2	ECOD (1.6)
D [auth J]	Fer2	e3eubJ2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2	ECOD (1.6)
G [auth S]	Fer2_2	e3eubS1	A: alpha bundles	X: CO dehydrogenase ISP C-domain like (From Topology)	H: CO dehydrogenase ISP C-domain like (From Topology)	T: CO dehydrogenase ISP C-domain like	F: Fer2_2	ECOD (1.6)
G [auth S]	Fer2	e3eubS2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2	ECOD (1.6)
J [auth 2]	Fer2_2	e3eub21	A: alpha bundles	X: CO dehydrogenase ISP C-domain like (From Topology)	H: CO dehydrogenase ISP C-domain like (From Topology)	T: CO dehydrogenase ISP C-domain like	F: Fer2_2	ECOD (1.6)
J [auth 2]	Fer2	e3eub22	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2	ECOD (1.6)
B	CO_deh_flav_C	e3eubB1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: SufE/NifU (From Topology)	T: SufE/NifU	F: CO_deh_flav_C	ECOD (1.6)
B	FAD_binding_5	e3eubB2	A: a+b complex topology	X: FAD-binding domain-like	H: FAD-binding domain (From Topology)	T: FAD-binding domain	F: FAD_binding_5	ECOD (1.6)
E [auth K]	CO_deh_flav_C	e3eubK1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: SufE/NifU (From Topology)	T: SufE/NifU	F: CO_deh_flav_C	ECOD (1.6)
E [auth K]	FAD_binding_5	e3eubK2	A: a+b complex topology	X: FAD-binding domain-like	H: FAD-binding domain (From Topology)	T: FAD-binding domain	F: FAD_binding_5	ECOD (1.6)
H [auth T]	CO_deh_flav_C	e3eubT1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: SufE/NifU (From Topology)	T: SufE/NifU	F: CO_deh_flav_C	ECOD (1.6)
H [auth T]	FAD_binding_5	e3eubT2	A: a+b complex topology	X: FAD-binding domain-like	H: FAD-binding domain (From Topology)	T: FAD-binding domain	F: FAD_binding_5	ECOD (1.6)
K [auth 3]	CO_deh_flav_C	e3eub31	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: SufE/NifU (From Topology)	T: SufE/NifU	F: CO_deh_flav_C	ECOD (1.6)
K [auth 3]	FAD_binding_5	e3eub32	A: a+b complex topology	X: FAD-binding domain-like	H: FAD-binding domain (From Topology)	T: FAD-binding domain	F: FAD_binding_5	ECOD (1.6)
C	Ald_Xan_dh_C2	e3eubC4	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Molybdenum cofactor-binding domain	F: Ald_Xan_dh_C2	ECOD (1.6)
C	Ald_Xan_dh_C	e3eubC2	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: Ald_Xan_dh_C	ECOD (1.6)
F [auth L]	Ald_Xan_dh_C2	e3eubL4	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Molybdenum cofactor-binding domain	F: Ald_Xan_dh_C2	ECOD (1.6)
F [auth L]	Ald_Xan_dh_C	e3eubL2	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: Ald_Xan_dh_C	ECOD (1.6)
I [auth U]	Ald_Xan_dh_C2	e3eubU4	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Molybdenum cofactor-binding domain	F: Ald_Xan_dh_C2	ECOD (1.6)
I [auth U]	Ald_Xan_dh_C	e3eubU2	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: Ald_Xan_dh_C	ECOD (1.6)
L [auth 4]	Ald_Xan_dh_C2	e3eub44	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Molybdenum cofactor-binding domain	F: Ald_Xan_dh_C2	ECOD (1.6)
L [auth 4]	Ald_Xan_dh_C	e3eub42	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: Ald_Xan_dh_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (4.3.0)
A	1.10.150.120	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
D [auth J]	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (4.3.0)
D [auth J]	1.10.150.120	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
G [auth S]	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (4.3.0)
G [auth S]	1.10.150.120	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
J [auth 2]	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (4.3.0)
J [auth 2]	1.10.150.120	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
B	3.30.43.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 2	CATH (4.3.0)
B	3.30.465.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 3	CATH (4.3.0)
B	3.30.390.50	Alpha Beta	2-Layer Sandwich	Enolase-like	domain 1	CATH (4.3.0)
E [auth K]	3.30.43.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 2	CATH (4.3.0)
E [auth K]	3.30.465.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 3	CATH (4.3.0)
E [auth K]	3.30.390.50	Alpha Beta	2-Layer Sandwich	Enolase-like	domain 1	CATH (4.3.0)
H [auth T]	3.30.43.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 2	CATH (4.3.0)
H [auth T]	3.30.465.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 3	CATH (4.3.0)
H [auth T]	3.30.390.50	Alpha Beta	2-Layer Sandwich	Enolase-like	domain 1	CATH (4.3.0)
K [auth 3]	3.30.43.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 2	CATH (4.3.0)
K [auth 3]	3.30.465.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 3	CATH (4.3.0)
K [auth 3]	3.30.390.50	Alpha Beta	2-Layer Sandwich	Enolase-like	domain 1	CATH (4.3.0)
C	3.90.1170.50	Alpha Beta	Alpha-Beta Complex	Aldehyde Oxidoreductase	domain 3	CATH (4.3.0)
C	3.30.365.10	Alpha Beta	2-Layer Sandwich	Aldehyde Oxidoreductase	domain 4	CATH (4.3.0)
F [auth L]	3.90.1170.50	Alpha Beta	Alpha-Beta Complex	Aldehyde Oxidoreductase	domain 3	CATH (4.3.0)
F [auth L]	3.30.365.10	Alpha Beta	2-Layer Sandwich	Aldehyde Oxidoreductase	domain 4	CATH (4.3.0)
I [auth U]	3.90.1170.50	Alpha Beta	Alpha-Beta Complex	Aldehyde Oxidoreductase	domain 3	CATH (4.3.0)
I [auth U]	3.30.365.10	Alpha Beta	2-Layer Sandwich	Aldehyde Oxidoreductase	domain 4	CATH (4.3.0)
L [auth 4]	3.90.1170.50	Alpha Beta	Alpha-Beta Complex	Aldehyde Oxidoreductase	domain 3	CATH (4.3.0)
L [auth 4]	3.30.365.10	Alpha Beta	2-Layer Sandwich	Aldehyde Oxidoreductase	domain 4	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D [auth J], G [auth S], J [auth 2]	PF01799	[2Fe-2S] binding domain (Fer2_2)	[2Fe-2S] binding domain	-	Domain
A, D [auth J], G [auth S], J [auth 2]	PF00111	2Fe-2S iron-sulfur cluster binding domain (Fer2)	2Fe-2S iron-sulfur cluster binding domain	-	Domain
B, E [auth K], H [auth T], K [auth 3]	PF00941	FAD binding domain in molybdopterin dehydrogenase (FAD_binding_5)	FAD binding domain in molybdopterin dehydrogenase	-	Family
B, E [auth K], H [auth T], K [auth 3]	PF03450	CO dehydrogenase flavoprotein C-terminal domain (CO_deh_flav_C)	CO dehydrogenase flavoprotein C-terminal domain	-	Domain
C, F [auth L], I [auth U], L [auth 4]	PF01315	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain (Ald_Xan_dh_C)	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	Domain
C, F [auth L], I [auth U], L [auth 4]	PF20256	Molybdopterin cofactor-binding domain (MoCoBD_2)	Molybdopterin cofactor-binding domain	-	Domain
C, F [auth L], I [auth U], L [auth 4]	PF02738	Molybdopterin cofactor-binding domain (MoCoBD_1)	Molybdopterin cofactor-binding domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D [auth J], G [auth S], J [auth 2]	Xanthine dehydrogenase/oxidase	FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor xanthine dehydrogenase activity FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor xanthine dehydrogenase activity catalytic activity identical protein binding protein binding protein homodimerization activity protein dimerization activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding metal cluster binding cation binding transition metal ion binding iron ion binding metal ion binding molybdenum ion binding molybdopterin cofactor binding oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor xanthine oxidase activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process purine nucleobase metabolic process primary metabolic process purine-containing compound catabolic process xanthine metabolic process purine nucleobase catabolic process organic cyclic compound catabolic process purine-containing compound metabolic process xanthine catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleobase-containing small molecule metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process purine nucleobase metabolic process primary metabolic process purine-containing compound catabolic process xanthine metabolic process purine nucleobase catabolic process organic cyclic compound catabolic process purine-containing compound metabolic process xanthine catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleobase-containing small molecule metabolic process nucleobase catabolic process nucleobase metabolic process small molecule metabolic process metabolic process organic substance catabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle peroxisome microbody cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex oxidoreductase complex xanthine dehydrogenase complex extracellular region membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle peroxisome microbody cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex oxidoreductase complex xanthine dehydrogenase complex extracellular region extracellular space
B, E [auth K], H [auth T], K [auth 3]	Xanthine dehydrogenase/oxidase	FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor xanthine dehydrogenase activity FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor xanthine dehydrogenase activity catalytic activity identical protein binding protein binding protein homodimerization activity protein dimerization activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding metal cluster binding cation binding transition metal ion binding iron ion binding metal ion binding molybdenum ion binding molybdopterin cofactor binding oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor xanthine oxidase activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process purine nucleobase metabolic process primary metabolic process purine-containing compound catabolic process xanthine metabolic process purine nucleobase catabolic process organic cyclic compound catabolic process purine-containing compound metabolic process xanthine catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleobase-containing small molecule metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process purine nucleobase metabolic process primary metabolic process purine-containing compound catabolic process xanthine metabolic process purine nucleobase catabolic process organic cyclic compound catabolic process purine-containing compound metabolic process xanthine catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleobase-containing small molecule metabolic process nucleobase catabolic process nucleobase metabolic process small molecule metabolic process metabolic process organic substance catabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle peroxisome microbody cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex oxidoreductase complex xanthine dehydrogenase complex extracellular region membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle peroxisome microbody cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex oxidoreductase complex xanthine dehydrogenase complex extracellular region extracellular space
C, F [auth L], I [auth U], L [auth 4]	Xanthine dehydrogenase/oxidase	FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor xanthine dehydrogenase activity FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor xanthine dehydrogenase activity catalytic activity identical protein binding protein binding protein homodimerization activity protein dimerization activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding metal cluster binding cation binding transition metal ion binding iron ion binding metal ion binding molybdenum ion binding molybdopterin cofactor binding oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor xanthine oxidase activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process purine nucleobase metabolic process primary metabolic process purine-containing compound catabolic process xanthine metabolic process purine nucleobase catabolic process organic cyclic compound catabolic process purine-containing compound metabolic process xanthine catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleobase-containing small molecule metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process purine nucleobase metabolic process primary metabolic process purine-containing compound catabolic process xanthine metabolic process purine nucleobase catabolic process organic cyclic compound catabolic process purine-containing compound metabolic process xanthine catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleobase-containing small molecule metabolic process nucleobase catabolic process nucleobase metabolic process small molecule metabolic process metabolic process organic substance catabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle peroxisome microbody cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex oxidoreductase complex xanthine dehydrogenase complex extracellular region membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle peroxisome microbody cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex oxidoreductase complex xanthine dehydrogenase complex extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D [auth J], G [auth S], J [auth 2]	IPR016167	FAD-binding, type PCMH, subdomain 1	Homologous Superfamily
A, D [auth J], G [auth S], J [auth 2]	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain	Domain
A, D [auth J], G [auth S], J [auth 2]	IPR006058	2Fe-2S ferredoxin, iron-sulphur binding site	Binding Site
A, D [auth J], G [auth S], J [auth 2]	IPR046867	Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain	Domain
A, D [auth J], G [auth S], J [auth 2]	IPR002888	[2Fe-2S]-binding	Domain
A, D [auth J], G [auth S], J [auth 2]	IPR036318	FAD-binding, type PCMH-like superfamily	Homologous Superfamily
A, D [auth J], G [auth S], J [auth 2]	IPR016208	Aldehyde oxidase/xanthine dehydrogenase-like	Family
A, D [auth J], G [auth S], J [auth 2]	IPR012675	Beta-grasp domain superfamily	Homologous Superfamily
A, D [auth J], G [auth S], J [auth 2]	IPR036683	CO dehydrogenase flavoprotein, C-terminal domain superfamily	Homologous Superfamily
A, D [auth J], G [auth S], J [auth 2]	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
A, D [auth J], G [auth S], J [auth 2]	IPR000674	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead	Domain
A, D [auth J], G [auth S], J [auth 2]	IPR022407	Oxidoreductase, molybdopterin binding site	Binding Site
A, D [auth J], G [auth S], J [auth 2]	IPR036856	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily	Homologous Superfamily
A, D [auth J], G [auth S], J [auth 2]	IPR037165	Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily	Homologous Superfamily
A, D [auth J], G [auth S], J [auth 2]	IPR016166	FAD-binding domain, PCMH-type	Domain
A, D [auth J], G [auth S], J [auth 2]	IPR002346	Molybdopterin dehydrogenase, FAD-binding	Domain
A, D [auth J], G [auth S], J [auth 2]	IPR014307	Xanthine dehydrogenase, small subunit	Domain
A, D [auth J], G [auth S], J [auth 2]	IPR016169	FAD-binding, type PCMH, subdomain 2	Homologous Superfamily
A, D [auth J], G [auth S], J [auth 2]	IPR036884	[2Fe-2S]-binding domain superfamily	Homologous Superfamily
A, D [auth J], G [auth S], J [auth 2]	IPR008274	Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain	Domain
A, D [auth J], G [auth S], J [auth 2]	IPR005107	CO dehydrogenase flavoprotein, C-terminal	Domain
B, E [auth K], H [auth T], K [auth 3]	IPR016167	FAD-binding, type PCMH, subdomain 1	Homologous Superfamily
B, E [auth K], H [auth T], K [auth 3]	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain	Domain
B, E [auth K], H [auth T], K [auth 3]	IPR006058	2Fe-2S ferredoxin, iron-sulphur binding site	Binding Site
B, E [auth K], H [auth T], K [auth 3]	IPR046867	Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain	Domain
B, E [auth K], H [auth T], K [auth 3]	IPR002888	[2Fe-2S]-binding	Domain
B, E [auth K], H [auth T], K [auth 3]	IPR036318	FAD-binding, type PCMH-like superfamily	Homologous Superfamily
B, E [auth K], H [auth T], K [auth 3]	IPR016208	Aldehyde oxidase/xanthine dehydrogenase-like	Family
B, E [auth K], H [auth T], K [auth 3]	IPR012675	Beta-grasp domain superfamily	Homologous Superfamily
B, E [auth K], H [auth T], K [auth 3]	IPR036683	CO dehydrogenase flavoprotein, C-terminal domain superfamily	Homologous Superfamily
B, E [auth K], H [auth T], K [auth 3]	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
B, E [auth K], H [auth T], K [auth 3]	IPR000674	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead	Domain
B, E [auth K], H [auth T], K [auth 3]	IPR022407	Oxidoreductase, molybdopterin binding site	Binding Site
B, E [auth K], H [auth T], K [auth 3]	IPR036856	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily	Homologous Superfamily
B, E [auth K], H [auth T], K [auth 3]	IPR037165	Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily	Homologous Superfamily
B, E [auth K], H [auth T], K [auth 3]	IPR016166	FAD-binding domain, PCMH-type	Domain
B, E [auth K], H [auth T], K [auth 3]	IPR002346	Molybdopterin dehydrogenase, FAD-binding	Domain
B, E [auth K], H [auth T], K [auth 3]	IPR014307	Xanthine dehydrogenase, small subunit	Domain
B, E [auth K], H [auth T], K [auth 3]	IPR016169	FAD-binding, type PCMH, subdomain 2	Homologous Superfamily
B, E [auth K], H [auth T], K [auth 3]	IPR036884	[2Fe-2S]-binding domain superfamily	Homologous Superfamily
B, E [auth K], H [auth T], K [auth 3]	IPR008274	Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain	Domain
B, E [auth K], H [auth T], K [auth 3]	IPR005107	CO dehydrogenase flavoprotein, C-terminal	Domain
C, F [auth L], I [auth U], L [auth 4]	IPR016167	FAD-binding, type PCMH, subdomain 1	Homologous Superfamily
C, F [auth L], I [auth U], L [auth 4]	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain	Domain
C, F [auth L], I [auth U], L [auth 4]	IPR006058	2Fe-2S ferredoxin, iron-sulphur binding site	Binding Site
C, F [auth L], I [auth U], L [auth 4]	IPR046867	Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain	Domain
C, F [auth L], I [auth U], L [auth 4]	IPR002888	[2Fe-2S]-binding	Domain
C, F [auth L], I [auth U], L [auth 4]	IPR036318	FAD-binding, type PCMH-like superfamily	Homologous Superfamily
C, F [auth L], I [auth U], L [auth 4]	IPR016208	Aldehyde oxidase/xanthine dehydrogenase-like	Family
C, F [auth L], I [auth U], L [auth 4]	IPR012675	Beta-grasp domain superfamily	Homologous Superfamily
C, F [auth L], I [auth U], L [auth 4]	IPR036683	CO dehydrogenase flavoprotein, C-terminal domain superfamily	Homologous Superfamily
C, F [auth L], I [auth U], L [auth 4]	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
C, F [auth L], I [auth U], L [auth 4]	IPR000674	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead	Domain
C, F [auth L], I [auth U], L [auth 4]	IPR022407	Oxidoreductase, molybdopterin binding site	Binding Site
C, F [auth L], I [auth U], L [auth 4]	IPR036856	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily	Homologous Superfamily
C, F [auth L], I [auth U], L [auth 4]	IPR037165	Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily	Homologous Superfamily
C, F [auth L], I [auth U], L [auth 4]	IPR016166	FAD-binding domain, PCMH-type	Domain
C, F [auth L], I [auth U], L [auth 4]	IPR002346	Molybdopterin dehydrogenase, FAD-binding	Domain
C, F [auth L], I [auth U], L [auth 4]	IPR014307	Xanthine dehydrogenase, small subunit	Domain
C, F [auth L], I [auth U], L [auth 4]	IPR016169	FAD-binding, type PCMH, subdomain 2	Homologous Superfamily
C, F [auth L], I [auth U], L [auth 4]	IPR036884	[2Fe-2S]-binding domain superfamily	Homologous Superfamily
C, F [auth L], I [auth U], L [auth 4]	IPR008274	Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain	Domain
C, F [auth L], I [auth U], L [auth 4]	IPR005107	CO dehydrogenase flavoprotein, C-terminal	Domain