3ET6

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3et6a1	Alpha and beta proteins (a+b)	Ferredoxin-like	Nucleotide cyclase	automated matches	automated matches	(Chlamydomonas reinhardtii ) [TaxId: 3055 ],	SCOPe (2.08)
A	d3et6a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Chlamydomonas reinhardtii ) [TaxId: 3055 ],	SCOPe (2.08)
B	d3et6b1	Alpha and beta proteins (a+b)	Ferredoxin-like	Nucleotide cyclase	automated matches	automated matches	(Chlamydomonas reinhardtii ) [TaxId: 3055 ],	SCOPe (2.08)
B	d3et6b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Chlamydomonas reinhardtii ) [TaxId: 3055 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Adenylyl and guanylyl cyclase catalytic domain	8064531	4001316	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8064532	3001272	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8064532	3001272	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Guanylate_cyc	e3et6A1	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: Guanylate_cyc	ECOD (1.6)
B	Guanylate_cyc	e3et6B1	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: Guanylate_cyc	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.70.1230	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Nucleotide cyclase, GGDEF domain	CATH (4.3.0)
B	3.30.70.1230	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Nucleotide cyclase, GGDEF domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00211	Adenylate and Guanylate cyclase catalytic domain (Guanylate_cyc)	Adenylate and Guanylate cyclase catalytic domain	-	Domain
B	PF00211	Adenylate and Guanylate cyclase catalytic domain (Guanylate_cyc)	Adenylate and Guanylate cyclase catalytic domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Soluble guanylyl cyclase beta	binding organic cyclic compound binding tetrapyrrole binding heme binding phosphorus-oxygen lyase activity cyclase activity lyase activity guanylate cyclase activity catalytic activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding binding organic cyclic compound binding tetrapyrrole binding heme binding phosphorus-oxygen lyase activity cyclase activity lyase activity guanylate cyclase activity catalytic activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling cGMP-mediated signaling biological regulation intracellular signal transduction cell communication intracellular signaling cassette cellular process signal transduction response to oxygen levels response to abiotic stimulus	guanylate cyclase complex, soluble protein-containing complex intracellular anatomical structure catalytic complex cytoplasm cellular anatomical entity cytosol
B	Soluble guanylyl cyclase beta	binding organic cyclic compound binding tetrapyrrole binding heme binding phosphorus-oxygen lyase activity cyclase activity lyase activity guanylate cyclase activity catalytic activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding binding organic cyclic compound binding tetrapyrrole binding heme binding phosphorus-oxygen lyase activity cyclase activity lyase activity guanylate cyclase activity catalytic activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling cGMP-mediated signaling biological regulation intracellular signal transduction cell communication intracellular signaling cassette cellular process signal transduction response to oxygen levels response to abiotic stimulus	guanylate cyclase complex, soluble protein-containing complex intracellular anatomical structure catalytic complex cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR018297	Adenylyl cyclase class-4/guanylyl cyclase, conserved site	Conserved Site
A	IPR038158	H-NOX domain superfamily	Homologous Superfamily
A	IPR024096	NO signalling/Golgi transport ligand-binding domain superfamily	Homologous Superfamily
A	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	Domain
A	IPR011644	Heme NO-binding	Domain
A	IPR011645	Haem NO binding associated	Domain
A	IPR042463	Haem NO binding associated domain superfamily	Homologous Superfamily
A	IPR029787	Nucleotide cyclase	Homologous Superfamily
B	IPR018297	Adenylyl cyclase class-4/guanylyl cyclase, conserved site	Conserved Site
B	IPR038158	H-NOX domain superfamily	Homologous Superfamily
B	IPR024096	NO signalling/Golgi transport ligand-binding domain superfamily	Homologous Superfamily
B	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	Domain
B	IPR011644	Heme NO-binding	Domain
B	IPR011645	Haem NO binding associated	Domain
B	IPR042463	Haem NO binding associated domain superfamily	Homologous Superfamily
B	IPR029787	Nucleotide cyclase	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.