3EH8

Crystal structure of Y2 I-AniI variant (F13Y/S111Y)/DNA complex with calcium

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3eh8a1	Alpha and beta proteins (a+b)	Homing endonuclease-like	Homing endonucleases	Group I mobile intron endonuclease	automated matches	Aspergillus nidulans (Aspergillus nidulans ) [TaxId: 162425 ],	SCOPe (2.08)
A	d3eh8a3	Artifacts	Tags	Tags	Tags	N-terminal Tags	Aspergillus nidulans (Aspergillus nidulans ) [TaxId: 162425 ],	SCOPe (2.08)
B [auth D]	d3eh8d1	Alpha and beta proteins (a+b)	Homing endonuclease-like	Homing endonucleases	Group I mobile intron endonuclease	automated matches	Aspergillus nidulans (Aspergillus nidulans ) [TaxId: 162425 ],	SCOPe (2.08)
B [auth D]	d3eh8d3	Artifacts	Tags	Tags	Tags	N-terminal Tags	Aspergillus nidulans (Aspergillus nidulans ) [TaxId: 162425 ],	SCOPe (2.08)
C [auth G]	d3eh8g1	Alpha and beta proteins (a+b)	Homing endonuclease-like	Homing endonucleases	Group I mobile intron endonuclease	automated matches	Aspergillus nidulans (Aspergillus nidulans ) [TaxId: 162425 ],	SCOPe (2.08)
C [auth G]	d3eh8g3	Artifacts	Tags	Tags	Tags	N-terminal Tags	Aspergillus nidulans (Aspergillus nidulans ) [TaxId: 162425 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Homing endonucleases	8038418	3000266	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Homing endonucleases	8038417	3000266	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	Homing endonucleases	8038417	3000266	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	Homing endonucleases	8038418	3000266	SCOP2B (2022-06-29)
C [auth G]	SCOP2B Superfamily	Homing endonucleases	8038417	3000266	SCOP2B (2022-06-29)
C [auth G]	SCOP2B Superfamily	Homing endonucleases	8038418	3000266	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00961	e3eh8A1	A: a+b two layers	X: Homing endonucleases-like	H: Homing endonucleases (From Topology)	T: Homing endonucleases	F: PF00961	ECOD (1.6)
B [auth D]	PF00961	e3eh8D1	A: a+b two layers	X: Homing endonucleases-like	H: Homing endonucleases (From Topology)	T: Homing endonucleases	F: PF00961	ECOD (1.6)
C [auth G]	PF00961	e3eh8G1	A: a+b two layers	X: Homing endonucleases-like	H: Homing endonucleases (From Topology)	T: Homing endonucleases	F: PF00961	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.28.10	Alpha Beta	Roll	Endonuclease I-creI	Homing endonucleases	CATH (4.3.0)
B [auth D]	3.10.28.10	Alpha Beta	Roll	Endonuclease I-creI	Homing endonucleases	CATH (4.3.0)
C [auth G]	3.10.28.10	Alpha Beta	Roll	Endonuclease I-creI	Homing endonucleases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth D], C [auth G]	PF00961	LAGLIDADG endonuclease (LAGLIDADG_1)	LAGLIDADG endonuclease	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth D], C [auth G]	Intron-encoded DNA endonuclease I-AniI	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds hydrolase activity catalytic activity	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process DNA recombination DNA metabolic process intron homing mRNA processing mRNA metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle
D [auth B], F [auth E], H	31-MER	-	-	-
E [auth C], G [auth F], I	31-MER	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth D], C [auth G]	IPR027387	Cytochrome b/b6-like domain superfamily	Homologous Superfamily
A, B [auth D], C [auth G]	IPR016174	Di-haem cytochrome, transmembrane	Homologous Superfamily
A, B [auth D], C [auth G]	IPR004860	Homing endonuclease, LAGLIDADG	Domain
A, B [auth D], C [auth G]	IPR048259	Cytochrome b/b6, N-terminal domain, eukaryotic/bacterial	Domain
A, B [auth D], C [auth G]	IPR027434	Homing endonuclease	Homologous Superfamily
A, B [auth D], C [auth G]	IPR005797	Cytochrome b/b6, N-terminal domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.