Annotations: 3EAY

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Peptidase_C48	e3eayA2	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: Peptidase_C48	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.418.20	Mainly Alpha	Orthogonal Bundle	Actin-binding Protein, T-fimbrin	domain 1	CATH (4.3.0)
A	3.30.310.130	Alpha Beta	2-Layer Sandwich	TATA-Binding Protein	Ubiquitin-related	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02902	Ulp1 protease family, C-terminal catalytic domain (Peptidase_C48)	Ulp1 protease family, C-terminal catalytic domain	This domain contains the catalytic triad Cys-His-Asn.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Sentrin-specific protease 7	cysteine-type peptidase activity peptidase activity ubiquitin-like protein peptidase activity catalytic activity, acting on a protein SUMO-specific endopeptidase activity cysteine-type endopeptidase activity hydrolase activity catalytic activity ubiquitin-like protein-specific endopeptidase activity endopeptidase activity	organonitrogen compound metabolic process peptidyl-lysine modification protein desumoylation primary metabolic process organic substance metabolic process protein modification by small protein removal macromolecule modification peptidyl-amino acid modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal organonitrogen compound metabolic process peptidyl-lysine modification protein desumoylation primary metabolic process organic substance metabolic process protein modification by small protein removal macromolecule modification peptidyl-amino acid modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus immune system process defense response to other organism response to stress innate immune response antiviral innate immune response response to external biotic stimulus response to virus proteolysis	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
A	IPR003653	Ulp1 protease family, C-terminal catalytic domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9BQF6	atypical teratoid rhabdoid tumor large cell medulloblastoma medulloblastoma primitive neuroectodermal tumor Gaucher disease malignant ependymoma osteosarcoma progressive supranuclear palsy inflammatory bowel disease malignant mesothelioma Pick disease

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.