3E9T

Crystal structure of Apo-form Calx CBD1 domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3e9ta1	All beta proteins	Immunoglobulin-like beta-sandwich	CalX-like	automated matches	automated matches	Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
A	d3e9ta2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
B	d3e9tb1	All beta proteins	Immunoglobulin-like beta-sandwich	CalX-like	automated matches	automated matches	Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
B	d3e9tb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
C	d3e9tc1	All beta proteins	Immunoglobulin-like beta-sandwich	CalX-like	automated matches	automated matches	Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
C	d3e9tc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
D	d3e9td_	All beta proteins	Immunoglobulin-like beta-sandwich	CalX-like	automated matches	automated matches	Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03160	e3e9tA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF03160	ECOD (1.6)
B	PF03160	e3e9tB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF03160	ECOD (1.6)
C	PF03160	e3e9tC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF03160	ECOD (1.6)
D	PF03160	e3e9tD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF03160	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.2030	Mainly Beta	Sandwich	Immunoglobulin-like	CalX-beta domain	CATH (4.3.0)
B	2.60.40.2030	Mainly Beta	Sandwich	Immunoglobulin-like	CalX-beta domain	CATH (4.3.0)
C	2.60.40.2030	Mainly Beta	Sandwich	Immunoglobulin-like	CalX-beta domain	CATH (4.3.0)
D	2.60.40.2030	Mainly Beta	Sandwich	Immunoglobulin-like	CalX-beta domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF03160	Calx-beta domain (Calx-beta)	Calx-beta domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Na/Ca exchange protein	monoatomic cation transmembrane transporter activity metal cation:monoatomic cation antiporter activity calcium:monoatomic cation antiporter activity sodium ion transmembrane transporter activity secondary active transmembrane transporter activity antiporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity calcium:sodium antiporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity monoatomic cation transmembrane transporter activity metal cation:monoatomic cation antiporter activity calcium:monoatomic cation antiporter activity sodium ion transmembrane transporter activity secondary active transmembrane transporter activity antiporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity calcium:sodium antiporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding calmodulin binding	multicellular organismal process system process nervous system process neuromuscular process neuromuscular process controlling posture phototransduction cellular response to stimulus detection of light stimulus response to light stimulus detection of external stimulus regulation of biological process regulation of cellular process response to stimulus signaling multicellular organismal process system process nervous system process neuromuscular process neuromuscular process controlling posture phototransduction cellular response to stimulus detection of light stimulus response to light stimulus detection of external stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation response to external stimulus detection of abiotic stimulus cell communication detection of stimulus cellular process response to abiotic stimulus response to radiation signal transduction cellular response to stress response to stress response to endoplasmic reticulum stress	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR032452	Sodium/calcium exchanger domain, C-terminal extension	Domain
A, B, C, D	IPR044880	NCX, central ion-binding domain superfamily	Homologous Superfamily
A, B, C, D	IPR004837	Sodium/calcium exchanger membrane region	Domain
A, B, C, D	IPR003644	Na-Ca exchanger/integrin-beta4	Domain
A, B, C, D	IPR038081	CalX-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR004836	Sodium/calcium exchanger protein	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.