Annotations: 3E9E

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	His_Phos_1	e3e9eA1	A: a/b three-layered sandwiches	X: Phosphoglycerate mutase-like (From Topology)	H: Phosphoglycerate mutase-like (From Topology)	T: Phosphoglycerate mutase-like	F: His_Phos_1	ECOD (1.6)
B	His_Phos_1	e3e9eB1	A: a/b three-layered sandwiches	X: Phosphoglycerate mutase-like (From Topology)	H: Phosphoglycerate mutase-like (From Topology)	T: Phosphoglycerate mutase-like	F: His_Phos_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1240	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Phosphoglycerate mutase-like	CATH (4.3.0)
B	3.40.50.1240	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Phosphoglycerate mutase-like	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Zgc:56074	catalytic activity phosphoric ester hydrolase activity fructose-2,6-bisphosphate 2-phosphatase activity hydrolase activity, acting on ester bonds carbohydrate phosphatase activity phosphatase activity hydrolase activity sugar-phosphatase activity	cellular catabolic process catabolic process cellular metabolic process autophagy cellular process metabolic process process utilizing autophagic mechanism pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process cellular catabolic process catabolic process cellular metabolic process autophagy cellular process metabolic process process utilizing autophagic mechanism pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of primary metabolic process regulation of ATP metabolic process regulation of purine nucleotide catabolic process negative regulation of nucleotide metabolic process regulation of small molecule metabolic process regulation of nucleotide metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process purine ribonucleotide catabolic process negative regulation of carbohydrate metabolic process nucleoside phosphate metabolic process organonitrogen compound catabolic process pyruvate metabolic process negative regulation of metabolic process negative regulation of purine nucleotide catabolic process purine nucleoside diphosphate metabolic process primary metabolic process purine-containing compound catabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process regulation of phosphorus metabolic process monocarboxylic acid metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process negative regulation of nucleotide catabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process organic cyclic compound catabolic process purine-containing compound metabolic process ADP metabolic process negative regulation of phosphorus metabolic process purine ribonucleoside diphosphate metabolic process organic substance catabolic process purine ribonucleoside diphosphate catabolic process ribonucleotide catabolic process regulation of cellular process negative regulation of small molecule metabolic process negative regulation of glycolytic process negative regulation of biological process negative regulation of ATP metabolic process negative regulation of cellular metabolic process nucleobase-containing compound metabolic process glycolytic process pyridine-containing compound metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process regulation of biological process regulation of cellular metabolic process nucleotide metabolic process organic cyclic compound metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process regulation of metabolic process organic substance metabolic process purine nucleotide metabolic process ribonucleotide metabolic process negative regulation of cellular process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process negative regulation of catabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process organonitrogen compound metabolic process biological regulation ADP catabolic process carboxylic acid metabolic process regulation of catabolic process generation of precursor metabolites and energy regulation of glycolytic process organophosphate metabolic process apoptotic process cell death programmed cell death regulation of amide metabolic process regulation of pentose-phosphate shunt pentose-phosphate shunt glucose 6-phosphate metabolic process regulation of NADP metabolic process amide metabolic process NADP metabolic process NADPH regeneration	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol mitochondrial membrane membrane organelle outer membrane organelle envelope bounding membrane of organelle membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol mitochondrial membrane membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013078	Histidine phosphatase superfamily, clade-1	Family
A, B	IPR001345	Phosphoglycerate/bisphosphoglycerate mutase, active site	Active Site
A, B	IPR029033	Histidine phosphatase superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.