Annotations: 3E5X

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3e5xa2	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	CAP C-terminal domain-like	Chlorophenol reduction protein CprK	(Desulfitobacterium hafniense DCB-2 ) [TaxId: 272564 ],	SCOPe (2.08)
A	d3e5xa1	All beta proteins	Double-stranded beta-helix	cAMP-binding domain-like	cAMP-binding domain	Chlorophenol reduction protein CprK	(Desulfitobacterium hafniense DCB-2 ) [TaxId: 272564 ],	SCOPe (2.08)
B [auth C]	d3e5xc2	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	CAP C-terminal domain-like	Chlorophenol reduction protein CprK	(Desulfitobacterium hafniense DCB-2 ) [TaxId: 272564 ],	SCOPe (2.08)
B [auth C]	d3e5xc1	All beta proteins	Double-stranded beta-helix	cAMP-binding domain-like	cAMP-binding domain	Chlorophenol reduction protein CprK	(Desulfitobacterium hafniense DCB-2 ) [TaxId: 272564 ],	SCOPe (2.08)
C [auth B]	d3e5xb2	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	CAP C-terminal domain-like	Chlorophenol reduction protein CprK	(Desulfitobacterium hafniense DCB-2 ) [TaxId: 272564 ],	SCOPe (2.08)
C [auth B]	d3e5xb1	All beta proteins	Double-stranded beta-helix	cAMP-binding domain-like	cAMP-binding domain	Chlorophenol reduction protein CprK	(Desulfitobacterium hafniense DCB-2 ) [TaxId: 272564 ],	SCOPe (2.08)
D	d3e5xd2	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	CAP C-terminal domain-like	Chlorophenol reduction protein CprK	(Desulfitobacterium hafniense DCB-2 ) [TaxId: 272564 ],	SCOPe (2.08)
D	d3e5xd1	All beta proteins	Double-stranded beta-helix	cAMP-binding domain-like	cAMP-binding domain	Chlorophenol reduction protein CprK	(Desulfitobacterium hafniense DCB-2 ) [TaxId: 272564 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	cAMP-binding domain-like	8017723	3000084	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Winged helix DNA-binding domain	8017720	3000034	SCOP2B (2022-06-29)
B [auth C]	SCOP2B Superfamily	cAMP-binding domain-like	8017723	3000084	SCOP2B (2022-06-29)
B [auth C]	SCOP2B Superfamily	Winged helix DNA-binding domain	8017720	3000034	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	cAMP-binding domain-like	8017723	3000084	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Winged helix DNA-binding domain	8017720	3000034	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Winged helix DNA-binding domain	8017720	3000034	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	cAMP-binding domain-like	8017723	3000084	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00027	e3e5xA1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: PF00027	ECOD (1.6)
A	PF13545	e3e5xA2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF13545	ECOD (1.6)
B [auth C]	PF00027	e3e5xC1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: PF00027	ECOD (1.6)
B [auth C]	PF13545	e3e5xC2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF13545	ECOD (1.6)
C [auth B]	PF00027	e3e5xB1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: PF00027	ECOD (1.6)
C [auth B]	PF13545	e3e5xB2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF13545	ECOD (1.6)
D	PF00027	e3e5xD1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: PF00027	ECOD (1.6)
D	PF13545	e3e5xD2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF13545	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
A	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
B [auth C]	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
B [auth C]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
C [auth B]	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
C [auth B]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
D	2.60.120.10	Mainly Beta	Sandwich	Jelly Rolls	Jelly Rolls	CATH (4.3.0)
D	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C], C [auth B], D	PF13545	Crp-like helix-turn-helix domain (HTH_Crp_2)	Crp-like helix-turn-helix domain	This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.	Domain
A, B [auth C], C [auth B], D	PF00027	Cyclic nucleotide-binding domain (cNMP_binding)	Cyclic nucleotide-binding domain	This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C], C [auth B], D	Cyclic nucleotide-binding protein	DNA binding binding organic cyclic compound binding nucleic acid binding	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C], C [auth B], D	IPR000595	Cyclic nucleotide-binding domain	Domain
A, B [auth C], C [auth B], D	IPR018490	Cyclic nucleotide-binding domain superfamily	Homologous Superfamily
A, B [auth C], C [auth B], D	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B [auth C], C [auth B], D	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A, B [auth C], C [auth B], D	IPR012318	Crp-type HTH domain	Domain
A, B [auth C], C [auth B], D	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.