3E4U

Crystal Structure of the Wild-Type Human BCL6 BTB/POZ Domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3e4ua_	Alpha and beta proteins (a+b)	POZ domain	POZ domain	BTB/POZ domain	B-cell lymphoma 6 (Bcl6) protein BTB domain	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3e4ub_	Alpha and beta proteins (a+b)	POZ domain	POZ domain	BTB/POZ domain	B-cell lymphoma 6 (Bcl6) protein BTB domain	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3e4uc_	Alpha and beta proteins (a+b)	POZ domain	POZ domain	BTB/POZ domain	B-cell lymphoma 6 (Bcl6) protein BTB domain	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3e4ud_	Alpha and beta proteins (a+b)	POZ domain	POZ domain	BTB/POZ domain	B-cell lymphoma 6 (Bcl6) protein BTB domain	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d3e4ue_	Alpha and beta proteins (a+b)	POZ domain	POZ domain	BTB/POZ domain	B-cell lymphoma 6 (Bcl6) protein BTB domain	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d3e4uf_	Alpha and beta proteins (a+b)	POZ domain	POZ domain	BTB/POZ domain	B-cell lymphoma 6 (Bcl6) protein BTB domain	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	POZ domain	8040250	3000894	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	POZ domain	8040250	3000894	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	POZ domain	8040250	3000894	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	POZ domain	8040250	3000894	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	POZ domain	8040250	3000894	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	POZ domain	8040250	3000894	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00651	e3e4uA1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: PF00651	ECOD (1.6)
B	PF00651	e3e4uB1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: PF00651	ECOD (1.6)
C	PF00651	e3e4uC1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: PF00651	ECOD (1.6)
D	PF00651	e3e4uD1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: PF00651	ECOD (1.6)
E	PF00651	e3e4uE1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: PF00651	ECOD (1.6)
F	PF00651	e3e4uF1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: PF00651	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.710.10	Alpha Beta	2-Layer Sandwich	Potassium Channel Kv1.1	Chain A	CATH (4.3.0)
B	3.30.710.10	Alpha Beta	2-Layer Sandwich	Potassium Channel Kv1.1	Chain A	CATH (4.3.0)
C	3.30.710.10	Alpha Beta	2-Layer Sandwich	Potassium Channel Kv1.1	Chain A	CATH (4.3.0)
D	3.30.710.10	Alpha Beta	2-Layer Sandwich	Potassium Channel Kv1.1	Chain A	CATH (4.3.0)
E	3.30.710.10	Alpha Beta	2-Layer Sandwich	Potassium Channel Kv1.1	Chain A	CATH (4.3.0)
F	3.30.710.10	Alpha Beta	2-Layer Sandwich	Potassium Channel Kv1.1	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00651	BTB/POZ domain (BTB)	BTB/POZ domain	The BTB (for BR-C, ttk and bab) [1] or POZ (for Pox virus and Zinc finger) [2] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family o ...	The BTB (for BR-C, ttk and bab) [1] or POZ (for Pox virus and Zinc finger) [2] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [2]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [3]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [4,5,6]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	B-cell lymphoma 6 protein	sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding sequence-specific double-stranded DNA binding double-stranded DNA binding cation binding ion binding metal ion binding small molecule binding identical protein binding protein binding transcription factor binding sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding sequence-specific double-stranded DNA binding double-stranded DNA binding cation binding ion binding metal ion binding small molecule binding identical protein binding protein binding transcription factor binding transcription coregulator binding transcription corepressor binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein-containing complex binding chromatin binding intronic transcription regulatory region sequence-specific DNA binding chromatin DNA binding DNA-binding transcription factor binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation protein localization localization cellular localization cellular macromolecule localization macromolecule localization multicellular organismal process regulation of cellular process regulation of leukocyte activation regulation of cell activation lymphocyte activation leukocyte proliferation leukocyte activation T cell activation lymphocyte proliferation regulation of multicellular organismal process regulation of immune system process T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation regulation of biological process cell population proliferation biological regulation cell activation regulation of T cell activation regulation of T cell proliferation regulation of cell population proliferation mononuclear cell proliferation immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation erythrocyte development cellular developmental process homeostatic process hemopoiesis cell development erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation cell differentiation anatomical structure development myeloid cell development homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis immunological memory formation process regulation of leukocyte differentiation regulation of immune effector process mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation cell activation involved in immune response regulation of cell development multicellular organism development T cell differentiation immune response immune effector process regulation of response to stimulus regulation of immune response leukocyte differentiation regulation of developmental process regulation of T cell differentiation memory T cell differentiation T cell activation involved in immune response leukocyte activation involved in immune response lymphocyte activation involved in immune response regulation of lymphocyte differentiation regulation of multicellular organismal development T cell differentiation involved in immune response regulation of memory T cell differentiation regulation of hemopoiesis immunological memory process negative regulation of mast cell cytokine production negative regulation of biological process negative regulation of cellular metabolic process cytokine production organic substance biosynthetic process negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response cellular metabolic process negative regulation of metabolic process negative regulation of immune effector process regulation of cellular metabolic process negative regulation of cellular biosynthetic process regulation of gene expression negative regulation of production of molecular mediator of immune response negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response negative regulation of multicellular organismal process regulation of metabolic process cellular biosynthetic process organic substance metabolic process regulation of cytokine production negative regulation of cellular process mast cell cytokine production myeloid leukocyte cytokine production cytokine production involved in immune response negative regulation of macromolecule metabolic process production of molecular mediator of immune response regulation of biosynthetic process regulation of mast cell cytokine production negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process negative regulation of immune system process negative regulation of biosynthetic process positive regulation of programmed cell death regulation of apoptotic process positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death positive regulation of cellular process regulation of alpha-beta T cell activation alpha-beta T cell differentiation involved in immune response negative regulation of cell adhesion negative regulation of T cell differentiation type 2 immune response regulation of T-helper cell differentiation regulation of type 2 immune response alpha-beta T cell activation T-helper cell differentiation negative regulation of leukocyte differentiation negative regulation of type 2 immune response negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion CD4-positive, alpha-beta T cell differentiation negative regulation of T-helper 2 cell differentiation alpha-beta T cell differentiation regulation of T-helper 2 cell differentiation regulation of cell-cell adhesion negative regulation of cell differentiation negative regulation of developmental process regulation of cell adhesion negative regulation of cell development regulation of CD4-positive, alpha-beta T cell activation negative regulation of alpha-beta T cell activation CD4-positive, alpha-beta T cell differentiation involved in immune response negative regulation of hemopoiesis negative regulation of immune response negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of lymphocyte differentiation negative regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of leukocyte activation regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation negative regulation of alpha-beta T cell differentiation negative regulation of lymphocyte activation leukocyte cell-cell adhesion cell adhesion cell-cell adhesion alpha-beta T cell activation involved in immune response CD4-positive, alpha-beta T cell activation T-helper 2 cell differentiation negative regulation of response to stimulus negative regulation of T-helper cell differentiation negative regulation of cell activation regulation of growth regulation of cellular component organization growth negative regulation of cell growth regulation of cell growth cell growth cellular component organization negative regulation of growth cellular component organization or biogenesis organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization anatomical structure morphogenesis cell morphogenesis positive regulation of cell population proliferation positive regulation of B cell proliferation positive regulation of lymphocyte activation positive regulation of cell activation regulation of B cell proliferation regulation of B cell activation positive regulation of leukocyte activation positive regulation of mononuclear cell proliferation positive regulation of immune system process B cell activation positive regulation of lymphocyte proliferation B cell proliferation positive regulation of B cell activation positive regulation of leukocyte proliferation positive regulation of multicellular organismal process positive regulation of locomotion regulation of cell motility regulation of locomotion positive regulation of cell motility cell motility locomotion mature B cell differentiation B cell activation involved in immune response regulation of plasma cell differentiation plasma cell differentiation negative regulation of plasma cell differentiation regulation of B cell differentiation B cell differentiation negative regulation of B cell activation negative regulation of B cell differentiation mature B cell differentiation involved in immune response regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II primary metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process small GTPase-mediated signal transduction signaling Rho protein signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains system development negative regulation of immunoglobulin production negative regulation of B cell mediated immunity DNA recombination DNA metabolic process negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of immunoglobulin mediated immune response B cell mediated immunity regulation of DNA metabolic process immunoglobulin production somatic cell DNA recombination somatic diversification of immunoglobulins involved in immune response somatic recombination of immunoglobulin gene segments regulation of immunoglobulin mediated immune response regulation of isotype switching somatic diversification of immune receptors via germline recombination within a single locus negative regulation of DNA metabolic process negative regulation of leukocyte mediated immunity lymphocyte mediated immunity regulation of DNA recombination negative regulation of lymphocyte mediated immunity regulation of isotype switching to IgE isotypes negative regulation of isotype switching to IgE isotypes leukocyte mediated immunity somatic diversification of immune receptors somatic recombination of immunoglobulin genes involved in immune response regulation of adaptive immune response negative regulation of adaptive immune response regulation of B cell mediated immunity somatic diversification of immunoglobulins negative regulation of DNA recombination regulation of leukocyte mediated immunity negative regulation of isotype switching isotype switching immune system development immunoglobulin production involved in immunoglobulin-mediated immune response regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains isotype switching to IgE isotypes adaptive immune response immunoglobulin mediated immune response regulation of immunoglobulin production regulation of lymphocyte mediated immunity mitotic DNA replication negative regulation of nuclear cell cycle DNA replication nuclear DNA replication negative regulation of cell cycle cell cycle DNA replication mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of DNA-templated DNA replication cell cycle regulation of cell cycle cell cycle process DNA-templated DNA replication negative regulation of DNA replication regulation of mitotic cell cycle DNA replication regulation of nuclear cell cycle DNA replication regulation of cell cycle process negative regulation of cell cycle process DNA replication mitotic cell cycle process regulation of DNA-templated DNA replication negative regulation of mitotic cell cycle DNA replication regulation of DNA replication regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process regulation of B cell apoptotic process negative regulation of programmed cell death leukocyte apoptotic process B cell apoptotic process negative regulation of B cell apoptotic process lymphocyte apoptotic process negative regulation of apoptotic process negative regulation of leukocyte apoptotic process negative regulation of lymphocyte apoptotic process cell-matrix adhesion cell-substrate adhesion positive regulation of T cell differentiation positive regulation of developmental process positive regulation of T cell activation positive regulation of cell development positive regulation of regulatory T cell differentiation positive regulation of leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of hemopoiesis positive regulation of cell differentiation positive regulation of cell adhesion regulation of regulatory T cell differentiation regulatory T cell differentiation positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of germinal center formation anatomical structure formation involved in morphogenesis germinal center formation regulation of anatomical structure morphogenesis negative regulation of signaling regulation of signal transduction negative regulation of cell communication regulation of signaling cell surface receptor signaling pathway negative regulation of signal transduction Notch signaling pathway negative regulation of Notch signaling pathway regulation of Notch signaling pathway regulation of cell communication negative regulation of cell population proliferation negative regulation of leukocyte proliferation negative regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction negative regulation of intracellular signal transduction regulation of intracellular signal transduction negative regulation of small GTPase mediated signal transduction regulation of Rho protein signal transduction positive regulation of neuron differentiation neurogenesis neuron differentiation nervous system development generation of neurons regulation of neuron differentiation regulation of defense response regulation of response to external stimulus defense response regulation of inflammatory response response to external stimulus regulation of response to stress inflammatory response regulation of cellular senescence cellular senescence negative regulation of cellular senescence protein-DNA complex organization chromatin organization chromatin remodeling heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression negative regulation of gene expression, epigenetic regulation of cell-substrate adhesion negative regulation of cell-matrix adhesion regulation of cell-matrix adhesion negative regulation of cell-substrate adhesion pyramidal neuron differentiation	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system nucleus membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system nucleus membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle nuclear body nucleoplasm paraspeckles

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR013087	Zinc finger C2H2-type	Domain
A, B, C, D, E A, B, C, D, E, F	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR000210	BTB/POZ domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: P41182	follicular lymphoma T-cell non-Hodgkin lymphoma lung carcinoma Lymphoma, Intermediate-Grade malignant mesothelioma medulloblastoma adenoma osteosarcoma atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia cancer primary mediastinal large B-cell lymphoma gastric carcinoma spondyloarthropathy hydrolethalus syndrome follicular lymphoma T-cell non-Hodgkin lymphoma lung carcinoma Lymphoma, Intermediate-Grade malignant mesothelioma medulloblastoma adenoma osteosarcoma atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia cancer primary mediastinal large B-cell lymphoma gastric carcinoma spondyloarthropathy hydrolethalus syndrome ulcerative colitis lymphoma lymphosarcoma malignant pancreatic neoplasm non-Hodgkin lymphoma ovarian cancer B-cell chronic lymphocytic leukemia Pick disease Crohn disease primitive neuroectodermal tumor ductal breast carcinoma in situ reticulum cell sarcoma glioblastoma subependymal giant cell astrocytoma invasive ductal breast carcinoma lung cancer malignant ependymoma MALT lymphoma oligodendroglioma astrocytic tumor pancreatic ductal adenocarcinoma breast carcinoma pituitary cancer dermatomyositis psoriasis rheumatoid arthritis large cell medulloblastoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.