3E3Q

Structure of the 3alpham13 high-affinity mutant of the 2C TCR in complex with Ld/QL9

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
G [auth C]	d3e3qc_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
BA [auth W]	d3e3qw_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D [auth E]	d3e3qe_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
FA [auth a]	d3e3qa_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
H [auth F]	d3e3qf_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
P [auth J]	d3e3qj_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
T [auth N]	d3e3qn_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
X [auth S]	d3e3qs_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	MHC antigen-recognition domain	8034809	3000521	SCOP2B (2022-06-29)
CA [auth Y]	SCOP2B Superfamily	MHC antigen-recognition domain	8034809	3000521	SCOP2B (2022-06-29)
E [auth B]	SCOP2B Superfamily	MHC antigen-recognition domain	8034809	3000521	SCOP2B (2022-06-29)
I [auth c]	SCOP2B Superfamily	MHC antigen-recognition domain	8034809	3000521	SCOP2B (2022-06-29)
M [auth H]	SCOP2B Superfamily	MHC antigen-recognition domain	8034809	3000521	SCOP2B (2022-06-29)
Q [auth L]	SCOP2B Superfamily	MHC antigen-recognition domain	8034809	3000521	SCOP2B (2022-06-29)
U [auth P]	SCOP2B Superfamily	MHC antigen-recognition domain	8034809	3000521	SCOP2B (2022-06-29)
Y [auth U]	SCOP2B Superfamily	MHC antigen-recognition domain	8034809	3000521	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MHC_I	e3e3qA1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
CA [auth Y]	MHC_I	e3e3qY1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
E [auth B]	MHC_I	e3e3qB1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
I [auth c]	MHC_I	e3e3qc1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
M [auth H]	MHC_I	e3e3qH1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
Q [auth L]	MHC_I	e3e3qL1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
U [auth P]	MHC_I	e3e3qP1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
Y [auth U]	MHC_I	e3e3qU1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
AA [auth V]	V-set_4	e3e3qV1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_4	ECOD (1.6)
C [auth D]	V-set_4	e3e3qD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_4	ECOD (1.6)
EA [auth Z]	V-set_4	e3e3qZ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_4	ECOD (1.6)
G [auth C]	V-set_4	e3e3qC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_4	ECOD (1.6)
K [auth d]	V-set_4	e3e3qd1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_4	ECOD (1.6)
O [auth I]	V-set_4	e3e3qI1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_4	ECOD (1.6)
S [auth M]	V-set_4	e3e3qM1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_4	ECOD (1.6)
W [auth R]	V-set_4	e3e3qR1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_4	ECOD (1.6)
BA [auth W]	V-set_3	e3e3qW1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
D [auth E]	V-set_3	e3e3qE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
FA [auth a]	V-set_3	e3e3qa1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
H [auth F]	V-set_3	e3e3qF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
L [auth e]	V-set_3	e3e3qe1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
P [auth J]	V-set_3	e3e3qJ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
T [auth N]	V-set_3	e3e3qN1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
X [auth S]	V-set_3	e3e3qS1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)
CA [auth Y]	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)
E [auth B]	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)
I [auth c]	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)
M [auth H]	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)
Q [auth L]	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)
U [auth P]	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)
Y [auth U]	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)
AA [auth V]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C [auth D]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
EA [auth Z]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
G [auth C]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
K [auth d]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
O [auth I]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
S [auth M]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
W [auth R]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
BA [auth W]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D [auth E]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
FA [auth a]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
H [auth F]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
L [auth e]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
P [auth J]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
T [auth N]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
X [auth S]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, CA [auth Y], E [auth B], I [auth c], M [auth H], A, CA [auth Y], E [auth B], I [auth c], M [auth H], Q [auth L], U [auth P], Y [auth U]	PF00129	Class I Histocompatibility antigen, domains alpha 1 and 2 (MHC_I)	Class I Histocompatibility antigen, domains alpha 1 and 2	-	Domain
AA [auth V], C [auth D], EA [auth Z], G [auth C], K [auth d], AA [auth V], C [auth D], EA [auth Z], G [auth C], K [auth d], O [auth I], S [auth M], W [auth R]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, CA [auth Y], E [auth B], I [auth c], M [auth H], A, CA [auth Y], E [auth B], I [auth c], M [auth H], Q [auth L], U [auth P], Y [auth U]	H-2 class I histocompatibility antigen, L-D alpha chain	binding antigen binding peptide antigen binding peptide binding protein binding protein-folding chaperone binding natural killer cell lectin-like receptor binding signaling receptor binding beta-2-microglobulin binding protein-containing complex binding T cell receptor binding MHC class I protein binding MHC protein binding	lymphocyte mediated immunity regulation of defense response regulation of immune effector process positive regulation of response to biotic stimulus regulation of response to biotic stimulus positive regulation of leukocyte mediated immunity biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus positive regulation of lymphocyte mediated immunity positive regulation of biological process response to biotic stimulus positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of immune response lymphocyte mediated immunity regulation of defense response regulation of immune effector process positive regulation of response to biotic stimulus regulation of response to biotic stimulus positive regulation of leukocyte mediated immunity biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus positive regulation of lymphocyte mediated immunity positive regulation of biological process response to biotic stimulus positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of immune response response to stress regulation of response to stress positive regulation of natural killer cell mediated immunity innate immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune effector process response to external biotic stimulus natural killer cell mediated immunity positive regulation of immune system process regulation of biological process regulation of natural killer cell mediated immunity positive regulation of innate immune response immune response response to other organism defense response regulation of innate immune response biological regulation defense response to symbiont response to external stimulus immune effector process regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response regulation of immune response multicellular organismal process regulation of cellular process regulation of leukocyte activation negative regulation of biological process regulation of cell activation lymphocyte activation negative regulation of lymphocyte activation negative regulation of natural killer cell activation leukocyte activation negative regulation of cellular process regulation of multicellular organismal process regulation of natural killer cell activation cell activation natural killer cell activation negative regulation of cell activation negative regulation of immune system process cellular process negative regulation of multicellular organismal process negative regulation of leukocyte activation regulation of lymphocyte activation positive regulation of cell population proliferation CD8-positive, alpha-beta T cell activation regulation of alpha-beta T cell activation CD8-positive, alpha-beta T cell proliferation positive regulation of alpha-beta T cell proliferation positive regulation of CD8-positive, alpha-beta T cell activation positive regulation of cell activation T cell activation alpha-beta T cell proliferation lymphocyte proliferation positive regulation of leukocyte activation positive regulation of CD8-positive, alpha-beta T cell proliferation alpha-beta T cell activation regulation of leukocyte proliferation positive regulation of T cell activation cell population proliferation regulation of CD8-positive, alpha-beta T cell proliferation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of alpha-beta T cell activation mononuclear cell proliferation regulation of cell population proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of multicellular organismal process positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion leukocyte proliferation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation regulation of alpha-beta T cell proliferation cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of cell-cell adhesion positive regulation of cellular process T cell proliferation regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of CD8-positive, alpha-beta T cell activation adaptive immune response cellular biosynthetic process interleukin-13 production positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process cytokine production organic substance biosynthetic process regulation of cytokine production positive regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of interleukin-13 production positive regulation of gene expression metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process regulation of interleukin-13 production positive regulation of cellular biosynthetic process humoral immune response antibacterial humoral response antimicrobial humoral response defense response to bacterium response to bacterium negative regulation of lymphocyte proliferation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion negative regulation of mononuclear cell proliferation negative regulation of cell population proliferation antigen processing and presentation antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent antigen processing and presentation of peptide antigen antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I negative regulation of lymphocyte mediated immunity negative regulation of natural killer cell mediated immunity negative regulation of immune response negative regulation of immune effector process leukocyte mediated cytotoxicity negative regulation of response to external stimulus negative regulation of defense response natural killer cell mediated cytotoxicity regulation of cell killing negative regulation of natural killer cell mediated cytotoxicity regulation of natural killer cell mediated cytotoxicity negative regulation of response to biotic stimulus protection from natural killer cell mediated cytotoxicity negative regulation of leukocyte mediated cytotoxicity negative regulation of cell killing negative regulation of response to stimulus regulation of leukocyte mediated cytotoxicity negative regulation of leukocyte mediated immunity cell killing negative regulation of innate immune response immunoglobulin production positive regulation of immunoglobulin production production of molecular mediator of immune response regulation of immunoglobulin production positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response positive regulation of natural killer cell activation immune system development developmental process multicellular organism development natural killer cell tolerance induction anatomical structure development tolerance induction system development antigen processing and presentation of peptide antigen via MHC class Ib antigen processing and presentation via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of exogenous antigen adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains T cell mediated immunity positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of leukocyte mediated cytotoxicity positive regulation of adaptive immune response regulation of T cell mediated immunity T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of adaptive immune response regulation of T cell mediated cytotoxicity positive regulation of T cell mediated immunity positive regulation of cell killing positive regulation of natural killer cell mediated cytotoxicity regulation of natural killer cell cytokine production regulation of cytokine production involved in immune response natural killer cell cytokine production cytokine production involved in immune response positive regulation of natural killer cell cytokine production positive regulation of cytokine production involved in immune response positive regulation of natural killer cell proliferation natural killer cell proliferation regulation of natural killer cell proliferation antigen processing and presentation of endogenous peptide antigen via MHC class Ib regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of interleukin-4 production positive regulation of interleukin-4 production interleukin-4 production positive regulation of TRAIL production TRAIL production regulation of TRAIL production defense response to Gram-positive bacterium positive regulation of acute inflammatory response to antigenic stimulus regulation of myeloid leukocyte mediated immunity regulation of acute inflammatory response to antigenic stimulus regulation of type IIa hypersensitivity myeloid leukocyte mediated immunity inflammatory response to antigenic stimulus positive regulation of hypersensitivity positive regulation of inflammatory response positive regulation of antibody-dependent cellular cytotoxicity antibody-dependent cellular cytotoxicity regulation of type II hypersensitivity positive regulation of immunoglobulin mediated immune response hypersensitivity regulation of inflammatory response regulation of B cell mediated immunity type II hypersensitivity positive regulation of myeloid leukocyte mediated immunity B cell mediated immunity type IIa hypersensitivity regulation of acute inflammatory response inflammatory response positive regulation of acute inflammatory response positive regulation of B cell mediated immunity regulation of immunoglobulin mediated immune response acute inflammatory response regulation of hypersensitivity regulation of inflammatory response to antigenic stimulus acute inflammatory response to antigenic stimulus positive regulation of inflammatory response to antigenic stimulus immunoglobulin mediated immune response positive regulation of type IIa hypersensitivity positive regulation of type II hypersensitivity regulation of antibody-dependent cellular cytotoxicity	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane MHC class I protein complex MHC protein complex protein-containing complex plasma membrane protein complex membrane protein complex MHC class Ib protein complex membrane-bounded organelle cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane MHC class I protein complex MHC protein complex protein-containing complex plasma membrane protein complex membrane protein complex MHC class Ib protein complex membrane-bounded organelle intracellular anatomical structure intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle endocytic vesicle membrane cytoplasm vesicle organelle membrane endocytic vesicle Golgi apparatus endomembrane system extracellular region extracellular space organelle subcompartment lumenal side of endoplasmic reticulum membrane lumenal side of membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane
B [auth Q], DA [auth b], F [auth G], J [auth f], N [auth K], B [auth Q], DA [auth b], F [auth G], J [auth f], N [auth K], R [auth O], V [auth T], Z [auth X]	QL9 peptide	-	-	-
AA [auth V], C [auth D], EA [auth Z], G [auth C], K [auth d], AA [auth V], C [auth D], EA [auth Z], G [auth C], K [auth d], O [auth I], S [auth M], W [auth R]	T-cell receptor alpha chain V region PHDS58	-	-	cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex cellular anatomical entity T cell receptor complex receptor complex
BA [auth W], D [auth E], FA [auth a], H [auth F], L [auth e], BA [auth W], D [auth E], FA [auth a], H [auth F], L [auth e], P [auth J], T [auth N], X [auth S]	TCR beta chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, CA [auth Y], E [auth B], I [auth c], M [auth H], A, CA [auth Y], E [auth B], I [auth c], M [auth H], Q [auth L], U [auth P], Y [auth U]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, CA [auth Y], E [auth B], I [auth c], M [auth H], A, CA [auth Y], E [auth B], I [auth c], M [auth H], Q [auth L], U [auth P], Y [auth U]	IPR010579	MHC class I, alpha chain, C-terminal	Domain
A, CA [auth Y], E [auth B], I [auth c], M [auth H], A, CA [auth Y], E [auth B], I [auth c], M [auth H], Q [auth L], U [auth P], Y [auth U]	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
A, CA [auth Y], E [auth B], I [auth c], M [auth H], A, CA [auth Y], E [auth B], I [auth c], M [auth H], Q [auth L], U [auth P], Y [auth U]	IPR001039	MHC class I alpha chain, alpha1 alpha2 domains	Domain
A, CA [auth Y], E [auth B], I [auth c], M [auth H], A, CA [auth Y], E [auth B], I [auth c], M [auth H], Q [auth L], U [auth P], Y [auth U]	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
A, CA [auth Y], E [auth B], I [auth c], M [auth H], A, CA [auth Y], E [auth B], I [auth c], M [auth H], Q [auth L], U [auth P], Y [auth U]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, CA [auth Y], E [auth B], I [auth c], M [auth H], A, CA [auth Y], E [auth B], I [auth c], M [auth H], Q [auth L], U [auth P], Y [auth U]	IPR007110	Immunoglobulin-like domain	Domain
A, CA [auth Y], E [auth B], I [auth c], M [auth H], A, CA [auth Y], E [auth B], I [auth c], M [auth H], Q [auth L], U [auth P], Y [auth U]	IPR003597	Immunoglobulin C1-set	Domain
A, CA [auth Y], E [auth B], I [auth c], M [auth H], A, CA [auth Y], E [auth B], I [auth c], M [auth H], Q [auth L], U [auth P], Y [auth U]	IPR011161	MHC class I-like antigen recognition-like	Domain
A, CA [auth Y], E [auth B], I [auth c], M [auth H], A, CA [auth Y], E [auth B], I [auth c], M [auth H], Q [auth L], U [auth P], Y [auth U]	IPR037055	MHC class I-like antigen recognition-like superfamily	Homologous Superfamily
AA [auth V], C [auth D], EA [auth Z], G [auth C], K [auth d], AA [auth V], C [auth D], EA [auth Z], G [auth C], K [auth d], O [auth I], S [auth M], W [auth R]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
AA [auth V], C [auth D], EA [auth Z], G [auth C], K [auth d], AA [auth V], C [auth D], EA [auth Z], G [auth C], K [auth d], O [auth I], S [auth M], W [auth R]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
AA [auth V], C [auth D], EA [auth Z], G [auth C], K [auth d], AA [auth V], C [auth D], EA [auth Z], G [auth C], K [auth d], O [auth I], S [auth M], W [auth R]	IPR013106	Immunoglobulin V-set domain	Domain
AA [auth V], C [auth D], EA [auth Z], G [auth C], K [auth d], AA [auth V], C [auth D], EA [auth Z], G [auth C], K [auth d], O [auth I], S [auth M], W [auth R]	IPR007110	Immunoglobulin-like domain	Domain