Annotations: 3E2H

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	MHC antigen-recognition domain	8034809	3000521	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8055397	3000071	SCOP2B (2022-06-29)
D [auth C]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054445	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00129	e3e2hA1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: PF00129	ECOD (1.6)
C [auth B]	PF07686	e3e2hB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
D [auth C]	PF07686	e3e2hC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)
C [auth B]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D [auth C]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A	MH1 H2-Ld-2	G-ALPHA1-ALPHA2	Mus musculus (house mouse)	H2-Ld-2, H2-L*03	G-DOMAIN G-ALPHA1, G-DOMAIN G-ALPHA2	MH	(G-ALPHA1-ALPHA2)	IMGT (202416-0)
C [auth B]	TR V(alpha)PHDS58 - V(beta)M67	V-ALPHA	Mus musculus (house mouse)	TRAV9-401, TRAJ3501, TRAJ35*02	V-DOMAIN V-ALPHA	TR	FV-ALPHA_BETA	IMGT (202416-0)
D [auth C]	TR V(alpha)PHDS58 - V(beta)M67	V-BETA	Mus musculus (house mouse)	TRBV13-201, TRBV13-203, TRBJ2-4*01	V-DOMAIN V-BETA	TR	FV-ALPHA_BETA	IMGT (202416-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00129	Class I Histocompatibility antigen, domains alpha 1 and 2 (MHC_I)	Class I Histocompatibility antigen, domains alpha 1 and 2	-	Domain
B [auth Q]	PF16870	2-oxoglutarate dehydrogenase C-terminal (OxoGdeHyase_C)	2-oxoglutarate dehydrogenase C-terminal	-	Family
C [auth B]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
D [auth C]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	H-2 class I histocompatibility antigen, L-D alpha chain	binding antigen binding peptide antigen binding peptide binding protein binding protein-folding chaperone binding natural killer cell lectin-like receptor binding signaling receptor binding beta-2-microglobulin binding protein-containing complex binding T cell receptor binding MHC class I protein binding MHC protein binding	lymphocyte mediated immunity regulation of defense response regulation of immune effector process positive regulation of response to biotic stimulus regulation of response to biotic stimulus positive regulation of leukocyte mediated immunity biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus positive regulation of lymphocyte mediated immunity positive regulation of biological process response to biotic stimulus positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of immune response lymphocyte mediated immunity regulation of defense response regulation of immune effector process positive regulation of response to biotic stimulus regulation of response to biotic stimulus positive regulation of leukocyte mediated immunity biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus positive regulation of lymphocyte mediated immunity positive regulation of biological process response to biotic stimulus positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of immune response response to stress regulation of response to stress positive regulation of natural killer cell mediated immunity innate immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune effector process response to external biotic stimulus natural killer cell mediated immunity positive regulation of immune system process regulation of biological process regulation of natural killer cell mediated immunity positive regulation of innate immune response immune response response to other organism defense response regulation of innate immune response biological regulation defense response to symbiont response to external stimulus immune effector process regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response regulation of immune response multicellular organismal process regulation of cellular process regulation of leukocyte activation negative regulation of biological process regulation of cell activation lymphocyte activation negative regulation of lymphocyte activation negative regulation of natural killer cell activation leukocyte activation negative regulation of cellular process regulation of multicellular organismal process regulation of natural killer cell activation cell activation natural killer cell activation negative regulation of cell activation negative regulation of immune system process cellular process negative regulation of multicellular organismal process negative regulation of leukocyte activation regulation of lymphocyte activation positive regulation of cell population proliferation CD8-positive, alpha-beta T cell activation regulation of alpha-beta T cell activation CD8-positive, alpha-beta T cell proliferation positive regulation of alpha-beta T cell proliferation positive regulation of CD8-positive, alpha-beta T cell activation positive regulation of cell activation T cell activation alpha-beta T cell proliferation lymphocyte proliferation positive regulation of leukocyte activation positive regulation of CD8-positive, alpha-beta T cell proliferation alpha-beta T cell activation regulation of leukocyte proliferation positive regulation of T cell activation cell population proliferation regulation of CD8-positive, alpha-beta T cell proliferation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of alpha-beta T cell activation mononuclear cell proliferation regulation of cell population proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of multicellular organismal process positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion leukocyte proliferation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation regulation of alpha-beta T cell proliferation cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of cell-cell adhesion positive regulation of cellular process T cell proliferation regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of CD8-positive, alpha-beta T cell activation adaptive immune response cellular biosynthetic process interleukin-13 production positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process cytokine production organic substance biosynthetic process regulation of cytokine production positive regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of interleukin-13 production positive regulation of gene expression metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process regulation of interleukin-13 production positive regulation of cellular biosynthetic process humoral immune response antibacterial humoral response antimicrobial humoral response defense response to bacterium response to bacterium negative regulation of lymphocyte proliferation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion negative regulation of mononuclear cell proliferation negative regulation of cell population proliferation antigen processing and presentation antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent antigen processing and presentation of peptide antigen antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I negative regulation of lymphocyte mediated immunity negative regulation of natural killer cell mediated immunity negative regulation of immune response negative regulation of immune effector process leukocyte mediated cytotoxicity negative regulation of response to external stimulus negative regulation of defense response natural killer cell mediated cytotoxicity regulation of cell killing negative regulation of natural killer cell mediated cytotoxicity regulation of natural killer cell mediated cytotoxicity negative regulation of response to biotic stimulus protection from natural killer cell mediated cytotoxicity negative regulation of leukocyte mediated cytotoxicity negative regulation of cell killing negative regulation of response to stimulus regulation of leukocyte mediated cytotoxicity negative regulation of leukocyte mediated immunity cell killing negative regulation of innate immune response immunoglobulin production positive regulation of immunoglobulin production production of molecular mediator of immune response regulation of immunoglobulin production positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response positive regulation of natural killer cell activation immune system development developmental process multicellular organism development natural killer cell tolerance induction anatomical structure development tolerance induction system development antigen processing and presentation of peptide antigen via MHC class Ib antigen processing and presentation via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of exogenous antigen adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains T cell mediated immunity positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of leukocyte mediated cytotoxicity positive regulation of adaptive immune response regulation of T cell mediated immunity T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of adaptive immune response regulation of T cell mediated cytotoxicity positive regulation of T cell mediated immunity positive regulation of cell killing positive regulation of natural killer cell mediated cytotoxicity regulation of natural killer cell cytokine production regulation of cytokine production involved in immune response natural killer cell cytokine production cytokine production involved in immune response positive regulation of natural killer cell cytokine production positive regulation of cytokine production involved in immune response positive regulation of natural killer cell proliferation natural killer cell proliferation regulation of natural killer cell proliferation antigen processing and presentation of endogenous peptide antigen via MHC class Ib regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of interleukin-4 production positive regulation of interleukin-4 production interleukin-4 production positive regulation of TRAIL production TRAIL production regulation of TRAIL production defense response to Gram-positive bacterium positive regulation of acute inflammatory response to antigenic stimulus regulation of myeloid leukocyte mediated immunity regulation of acute inflammatory response to antigenic stimulus regulation of type IIa hypersensitivity myeloid leukocyte mediated immunity inflammatory response to antigenic stimulus positive regulation of hypersensitivity positive regulation of inflammatory response positive regulation of antibody-dependent cellular cytotoxicity antibody-dependent cellular cytotoxicity regulation of type II hypersensitivity positive regulation of immunoglobulin mediated immune response hypersensitivity regulation of inflammatory response regulation of B cell mediated immunity type II hypersensitivity positive regulation of myeloid leukocyte mediated immunity B cell mediated immunity type IIa hypersensitivity regulation of acute inflammatory response inflammatory response positive regulation of acute inflammatory response positive regulation of B cell mediated immunity regulation of immunoglobulin mediated immune response acute inflammatory response regulation of hypersensitivity regulation of inflammatory response to antigenic stimulus acute inflammatory response to antigenic stimulus positive regulation of inflammatory response to antigenic stimulus immunoglobulin mediated immune response positive regulation of type IIa hypersensitivity positive regulation of type II hypersensitivity regulation of antibody-dependent cellular cytotoxicity	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane MHC class I protein complex MHC protein complex protein-containing complex plasma membrane protein complex membrane protein complex MHC class Ib protein complex membrane-bounded organelle cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane MHC class I protein complex MHC protein complex protein-containing complex plasma membrane protein complex membrane protein complex MHC class Ib protein complex membrane-bounded organelle intracellular anatomical structure intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle endocytic vesicle membrane cytoplasm vesicle organelle membrane endocytic vesicle Golgi apparatus endomembrane system extracellular region extracellular space organelle subcompartment lumenal side of endoplasmic reticulum membrane lumenal side of membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane
B [auth Q]	QL9 PEPTIDE	protein binding binding heat shock protein binding protein-folding chaperone binding cation binding vitamin binding thiamine pyrophosphate binding ion binding organic cyclic compound binding anion binding quaternary ammonium group binding heterocyclic compound binding small molecule binding sulfur compound binding protein binding binding heat shock protein binding protein-folding chaperone binding cation binding vitamin binding thiamine pyrophosphate binding ion binding organic cyclic compound binding anion binding quaternary ammonium group binding heterocyclic compound binding small molecule binding sulfur compound binding oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors oxoglutarate dehydrogenase (succinyl-transferring) activity catalytic activity metal ion binding oxoglutarate dehydrogenase (NAD+) activity oxoglutarate dehydrogenase [NAD(P)+] activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	developmental process multicellular organismal process head development animal organ development brain development nervous system development cerebellar cortex development multicellular organism development cerebellum development central nervous system development metencephalon development anatomical structure development hindbrain development system development developmental process multicellular organismal process head development animal organ development brain development nervous system development cerebellar cortex development multicellular organism development cerebellum development central nervous system development metencephalon development anatomical structure development hindbrain development system development forebrain development olfactory lobe development tangential migration from the subventricular zone to the olfactory bulb telencephalon cell migration forebrain cell migration cell migration cellular process telencephalon development cell motility olfactory bulb development pallium development hippocampus development limbic system development pyramidal neuron development cellular developmental process central nervous system neuron development cell development neurogenesis central nervous system neuron differentiation neuron differentiation cell differentiation forebrain generation of neurons generation of neurons forebrain neuron development neuron development forebrain neuron differentiation pyramidal neuron differentiation ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organic substance metabolic process acyl-CoA metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process sulfur compound metabolic process succinyl-CoA metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process nucleoside phosphate metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process organic cyclic compound metabolic process organophosphate metabolic process metabolic process purine ribonucleotide metabolic process generation of precursor metabolites and energy diencephalon development thalamus development aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process nucleoside phosphate catabolic process organic acid metabolic process glycolytic process pyridine-containing compound metabolic process purine ribonucleotide catabolic process pyridine nucleotide metabolic process organonitrogen compound catabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process pyridine-containing compound catabolic process catabolic process ATP metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process ADP catabolic process carboxylic acid metabolic process organic cyclic compound catabolic process ADP metabolic process purine ribonucleoside diphosphate metabolic process organic substance catabolic process purine ribonucleoside diphosphate catabolic process olfactory bulb mitral cell layer development striatum development subpallium development NAD metabolic process NADH metabolic process 2-oxoglutarate metabolic process dicarboxylic acid metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane membrane organelle envelope mitochondrial envelope organelle membrane protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane membrane organelle envelope mitochondrial envelope organelle membrane protein-containing complex oxoglutarate dehydrogenase complex catalytic complex oxidoreductase complex tricarboxylic acid cycle heteromeric enzyme complex alpha-ketoacid dehydrogenase complex nucleus
C [auth B]	T-cell receptor alpha chain V region PHDS58	-	response to stimulus immune response immune system process adaptive immune response	cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex cellular anatomical entity T cell receptor complex receptor complex
D [auth C]	M67 TCR beta chain	-	response to stimulus immune response immune system process adaptive immune response	cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex cellular anatomical entity T cell receptor complex receptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR010579	MHC class I, alpha chain, C-terminal	Domain
A	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
A	IPR001039	MHC class I alpha chain, alpha1 alpha2 domains	Domain
A	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR007110	Immunoglobulin-like domain	Domain
A	IPR003597	Immunoglobulin C1-set	Domain
A	IPR011161	MHC class I-like antigen recognition-like	Domain
A	IPR037055	MHC class I-like antigen recognition-like superfamily	Homologous Superfamily
B [auth Q]	IPR031717	Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal	Domain
B [auth Q]	IPR042179	Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily	Homologous Superfamily
B [auth Q]	IPR005475	Transketolase-like, pyrimidine-binding domain	Domain
B [auth Q]	IPR001017	Dehydrogenase, E1 component	Domain
B [auth Q]	IPR029061	Thiamin diphosphate-binding fold	Homologous Superfamily
B [auth Q]	IPR032106	2-oxoglutarate dehydrogenase E1 component, N-terminal domain	Domain
B [auth Q]	IPR011603	2-oxoglutarate dehydrogenase E1 component	Family
C [auth B]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C [auth B]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
C [auth B]	IPR003599	Immunoglobulin subtype	Domain
C [auth B]	IPR013106	Immunoglobulin V-set domain	Domain
C [auth B]	IPR007110	Immunoglobulin-like domain	Domain
D [auth C]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
D [auth C]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
D [auth C]	IPR003599	Immunoglobulin subtype	Domain
D [auth C]	IPR013106	Immunoglobulin V-set domain	Domain
D [auth C]	IPR007110	Immunoglobulin-like domain	Domain