3E1Z

Crystal structure of the parasite protesase inhibitor chagasin in complex with papain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3e1za_	All beta proteins	Immunoglobulin-like beta-sandwich	ICP-like	ICP-like	Chagasin	(Trypanosoma cruzi ) [TaxId: 5693 ],	SCOPe (2.08)
B	d3e1zb_	Alpha and beta proteins (a+b)	Cysteine proteinases	Cysteine proteinases	Papain-like	Papain	(Carica papaya ) [TaxId: 3649 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ICP-like	8055379	3002058	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cysteine proteinases	8036216	3001808	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Inhibitor_I42	e3e1zA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Inhibitor_I42	ECOD (1.6)
B	Peptidase_C1	e3e1zB1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: Peptidase_C1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.2020	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
B	3.90.70.10	Alpha Beta	Alpha-Beta Complex	Cathepsin B	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF09394	Chagasin family peptidase inhibitor I42 (Inhibitor_I42)	Chagasin family peptidase inhibitor I42	Chagasin is a cysteine peptidase inhibitor [1] which forms a beta barrel structure [2].	Domain
B	PF00112	Papain family cysteine protease (Peptidase_C1)	Papain family cysteine protease	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Chagasin	enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity cysteine-type endopeptidase inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity	-	cell surface cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm intracellular membrane-bounded organelle vesicle ciliary pocket cell projection cilium cell surface cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm intracellular membrane-bounded organelle vesicle ciliary pocket cell projection cilium plasma membrane bounded cell projection
B	Papain	protein binding binding serpin family protein binding cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036331	Chagasin-like superfamily	Homologous Superfamily
A	IPR018990	Proteinase inhibitor I42, chagasin	Domain
B	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
B	IPR025661	Cysteine peptidase, asparagine active site	Active Site
B	IPR000169	Cysteine peptidase, cysteine active site	Active Site
B	IPR025660	Cysteine peptidase, histidine active site	Active Site
B	IPR013128	Peptidase C1A	Family
B	IPR000668	Peptidase C1A, papain C-terminal	Domain
B	IPR013201	Cathepsin propeptide inhibitor domain (I29)	Domain
B	IPR039417	Papain-like cysteine endopeptidase	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.