3DWB

structure of human ECE-1 complexed with phosphoramidon

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3dwba_	Alpha and beta proteins (a+b)	Zincin-like	Metalloproteases ('zincins'), catalytic domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Neutral endopeptidase (neprilysin)	8073706	4001611	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Metalloproteases (zincins) catalytic domain	8073707	3001975	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Peptidase_M13	e3dwbA1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M13	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.390.10	Alpha Beta	3-Layer(aba) Sandwich	Collagenase (Catalytic Domain)	Collagenase (Catalytic Domain)	CATH (4.3.0)
A	1.10.1380.10	Mainly Alpha	Orthogonal Bundle	Neutral endopeptidase	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF05649	Peptidase family M13 (Peptidase_M13_N)	Peptidase family M13	-	Family
A	PF01431	Peptidase family M13 (Peptidase_M13)	Peptidase family M13	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Endothelin-converting enzyme 1	peptidase activity catalytic activity, acting on a protein metalloendopeptidase activity hydrolase activity metallopeptidase activity catalytic activity endopeptidase activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity amide binding peptide hormone binding peptidase activity catalytic activity, acting on a protein metalloendopeptidase activity hydrolase activity metallopeptidase activity catalytic activity endopeptidase activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity amide binding peptide hormone binding hormone binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development ear development sensory organ development regulation of systemic arterial blood pressure by endothelin regulation of systemic arterial blood pressure by hormone regulation of systemic arterial blood pressure mediated by a chemical signal system process developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development ear development sensory organ development regulation of systemic arterial blood pressure by endothelin regulation of systemic arterial blood pressure by hormone regulation of systemic arterial blood pressure mediated by a chemical signal system process regulation of blood pressure biological regulation regulation of systemic arterial blood pressure circulatory system process endocrine process regulation of biological quality blood circulation regulation of tube diameter regulation of biological process regulation of tube size regulation of system process regulation of blood circulation regulation of vasoconstriction vascular process in circulatory system regulation of multicellular organismal process blood vessel diameter maintenance vasoconstriction regulation of anatomical structure size peptide hormone processing cellular biosynthetic process signaling receptor ligand precursor processing protein maturation organic substance metabolic process proteolysis organic substance biosynthetic process amide metabolic process protein metabolic process organonitrogen compound metabolic process regulation of hormone levels cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process hormone metabolic process biosynthetic process protein processing metabolic process cellular process macromolecule metabolic process epithelium development tube development embryo development tissue development embryonic heart tube development embryonic organ development organonitrogen compound catabolic process catabolic process substance P catabolic process peptide catabolic process cellular catabolic process neuropeptide catabolic process organic substance catabolic process peptide metabolic process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation sympathetic neuron axon guidance cellular component organization or biogenesis plasma membrane bounded cell projection organization axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development embryo development ending in birth or egg hatching pharyngeal system development chordate embryonic development regulation of signaling signaling regulation of receptor recycling positive regulation of biological process regulation of macromolecule metabolic process receptor recycling positive regulation of metabolic process receptor metabolic process positive regulation of receptor recycling positive regulation of macromolecule metabolic process regulation of metabolic process positive regulation of signaling calcitonin catabolic process hormone catabolic process endothelin maturation cellular response to stimulus regulation of cellular process response to stimulus G protein-coupled receptor signaling pathway signal transduction cell communication bradykinin catabolic process innervation nerve development axonogenesis involved in innervation limb development appendage development embryonic limb morphogenesis embryonic morphogenesis embryonic appendage morphogenesis appendage morphogenesis embryonic digit morphogenesis limb morphogenesis semaphorin-plexin signaling pathway semaphorin-plexin signaling pathway involved in neuron projection guidance semaphorin-plexin signaling pathway involved in axon guidance cell surface receptor signaling pathway	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane membrane-bounded organelle organelle vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane membrane-bounded organelle organelle vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle Weibel-Palade body secretory granule clathrin-coated vesicle secretory vesicle coated vesicle cytoplasm early endosome endosome vacuolar membrane lytic vacuole vacuole lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane lysosome perinuclear region of cytoplasm endosome membrane cytoplasmic vesicle membrane vesicle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000718	Peptidase M13	Family
A	IPR024079	Metallopeptidase, catalytic domain superfamily	Homologous Superfamily
A	IPR018497	Peptidase M13, C-terminal domain	Domain
A	IPR008753	Peptidase M13, N-terminal domain	Domain
A	IPR042089	Peptidase M13, domain 2	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P42892	Hirschsprung disease Hirschsprung disease, cardiac defects, and autonomic dysfunction hypertensive disorder type 2 diabetes mellitus essential hypertension Craniofacial Abnormalities ovarian cancer subependymal giant cell astrocytoma acute diarrhea autonomic nervous system disease intestinal disease congenital heart disease MALT lymphoma bowel dysfunction essential hypertension, genetic Hirschsprung disease Hirschsprung disease, cardiac defects, and autonomic dysfunction hypertensive disorder type 2 diabetes mellitus essential hypertension Craniofacial Abnormalities ovarian cancer subependymal giant cell astrocytoma acute diarrhea autonomic nervous system disease intestinal disease congenital heart disease MALT lymphoma bowel dysfunction essential hypertension, genetic maturity-onset diabetes of the young

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.