3DLX

Crystal structure of human 3-oxoacid CoA transferase 1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3dlxa1	Alpha and beta proteins (a/b)	NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	CoA transferase alpha subunit-like	Succinate:CoA transferase, N-terminal domain	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3dlxa2	Alpha and beta proteins (a/b)	NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	CoA transferase beta subunit-like	Succinate:CoA transferase, C-terminal domain	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3dlxb1	Alpha and beta proteins (a/b)	NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	CoA transferase alpha subunit-like	Succinate:CoA transferase, N-terminal domain	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3dlxb2	Alpha and beta proteins (a/b)	NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	CoA transferase beta subunit-like	Succinate:CoA transferase, C-terminal domain	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3dlxc1	Alpha and beta proteins (a/b)	NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	CoA transferase alpha subunit-like	Succinate:CoA transferase, N-terminal domain	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3dlxc2	Alpha and beta proteins (a/b)	NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	CoA transferase beta subunit-like	Succinate:CoA transferase, C-terminal domain	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3dlxd1	Alpha and beta proteins (a/b)	NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	CoA transferase alpha subunit-like	Succinate:CoA transferase, N-terminal domain	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3dlxd2	Alpha and beta proteins (a/b)	NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	CoA transferase beta subunit-like	Succinate:CoA transferase, C-terminal domain	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01144	e3dlxA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: PF01144	ECOD (1.6)
B	PF01144	e3dlxB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: PF01144	ECOD (1.6)
C	PF01144	e3dlxC5	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: PF01144	ECOD (1.6)
D	PF01144	e3dlxD1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: PF01144	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.1080.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaconate Coenzyme A-transferase	Glutaconate Coenzyme A-transferase	CATH (4.3.0)
B	3.40.1080.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaconate Coenzyme A-transferase	Glutaconate Coenzyme A-transferase	CATH (4.3.0)
C	3.40.1080.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaconate Coenzyme A-transferase	Glutaconate Coenzyme A-transferase	CATH (4.3.0)
D	3.40.1080.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaconate Coenzyme A-transferase	Glutaconate Coenzyme A-transferase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01144	Coenzyme A transferase (CoA_trans)	Coenzyme A transferase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1	succinyl-CoA:3-oxo-acid CoA-transferase activity transferase activity, transferring sulphur-containing groups transferase activity catalytic activity CoA-transferase activity	catabolic process lipid catabolic process cellular metabolic process ketone body catabolic process primary metabolic process generation of precursor metabolites and energy fatty acid derivative catabolic process fatty acid derivative metabolic process cellular catabolic process organic substance metabolic process cellular ketone body metabolic process small molecule metabolic process metabolic process ketone body metabolic process catabolic process lipid catabolic process cellular metabolic process ketone body catabolic process primary metabolic process generation of precursor metabolites and energy fatty acid derivative catabolic process fatty acid derivative metabolic process cellular catabolic process organic substance metabolic process cellular ketone body metabolic process small molecule metabolic process metabolic process ketone body metabolic process cellular process small molecule catabolic process organic substance catabolic process lipid metabolic process cellular ketone metabolic process ketone catabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR012792	3-oxoacid CoA-transferase, subunit A	Domain
A, B, C, D	IPR004165	Coenzyme A transferase family I	Family
A, B, C, D	IPR012791	3-oxoacid CoA-transferase, subunit B	Domain
A, B, C, D	IPR004164	Coenzyme A transferase active site	Active Site
A, B, C, D	IPR004163	Coenzyme A transferase binding site	Binding Site
A, B, C, D	IPR037171	NagB/RpiA transferase-like	Homologous Superfamily
A, B, C, D	IPR014388	3-oxoacid CoA-transferase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P55809	succinyl-CoA:3-ketoacid CoA transferase deficiency osteoporosis pilocytic astrocytoma astrocytic tumor Deficiency of 3-oxoacid CoA-transferase intellectual disability lung carcinoma malignant glioma oligodendroglioma atypical teratoid rhabdoid tumor gastric carcinoma lymphoplasmacytic lymphoma malignant mesothelioma Pick disease primitive neuroectodermal tumor succinyl-CoA:3-ketoacid CoA transferase deficiency osteoporosis pilocytic astrocytoma astrocytic tumor Deficiency of 3-oxoacid CoA-transferase intellectual disability lung carcinoma malignant glioma oligodendroglioma atypical teratoid rhabdoid tumor gastric carcinoma lymphoplasmacytic lymphoma malignant mesothelioma Pick disease primitive neuroectodermal tumor Crohn disease glioblastoma large cell medulloblastoma malignant ependymoma medulloblastoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.