3DKN

Sec61 in the Canine ribosome-channel complex from the endoplasmic reticulum

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E [auth B]	d3dknb1	Membrane and cell surface proteins and peptides	Single transmembrane helix	Preprotein translocase SecE subunit	Preprotein translocase SecE subunit	Preprotein translocase SecE subunit	(Canis lupus familiaris ) [TaxId: 9615 ],	SCOPe (2.08)
F [auth C]	d3dknc1	Membrane and cell surface proteins and peptides	Transmembrane helix hairpin	Sec-beta or SecG subunit of protein translocation channel	Sec-beta subunit	Sec-beta subunit	(Canis lupus familiaris ) [TaxId: 9615 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D [auth A]	SCOP2B Superfamily	SecY-like	8040629	3000333	SCOP2B (2022-06-29)
E [auth B]	SCOP2B Superfamily	Protein translocase subunit SecE-like	8040630	3002174	SCOP2B (2022-06-29)
F [auth C]	SCOP2B Superfamily	Sec-beta subunit	8040632	3000289	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D [auth A]	PF00344,PF10559	e3dknA1	A: alpha complex topology	X: Preprotein translocase SecY subunit (From Topology)	H: Preprotein translocase SecY subunit (From Topology)	T: Preprotein translocase SecY subunit	F: PF00344,PF10559	ECOD (1.6)
E [auth B]	PF00584	e3dknB1	A: extended segments	X: Preprotein translocase SecE subunit (From Topology)	H: Preprotein translocase SecE subunit (From Topology)	T: Preprotein translocase SecE subunit	F: PF00584	ECOD (1.6)
F [auth C]	PF03911	e3dknC1	A: extended segments	X: Sec-beta subunit (From Topology)	H: Sec-beta subunit (From Topology)	T: Sec-beta subunit	F: PF03911	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
D [auth A]	PF10559	Plug domain of Sec61p (Plug_translocon)	Plug domain of Sec61p	The Sec61/SecY translocon mediates translocation of proteins across the membrane and integration of membrane proteins into the lipid bilayer. The structure of the translocon revealed a plug domain blocking the pore on the lumenal side.The plug is unl ...	The Sec61/SecY translocon mediates translocation of proteins across the membrane and integration of membrane proteins into the lipid bilayer. The structure of the translocon revealed a plug domain blocking the pore on the lumenal side.The plug is unlikely to be important for sealing the translocation pore in yeast but it plays a role in stabilising Sec61p during translocon formation. The domain runs from residues 52-74 [1].	Domain
D [auth A]	PF00344	SecY (SecY)	SecY	-	Family
E [auth B]	PF00584	SecE/Sec61-gamma subunits of protein translocation complex (SecE)	SecE/Sec61-gamma subunits of protein translocation complex	-	Family
F [auth C]	PF03911	Sec61beta family (Sec61_beta)	Sec61beta family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D]	RNA (5'-R(PCPGPUPGPCPCPAPAPGPCPUPGPCPGPAPUPAPAPGPC)-3')	-	-	-
B [auth E]	RNA (5'-R(PAPGPCPCPGPCPAPCPGPGPAPGPGPCPGPAP*A)-3')	-	-	-
C [auth F]	RNA (32-MER)	-	-	-
D [auth A]	Preprotein translocase subunit secY	macromolecule transmembrane transporter activity protein transporter activity protein transmembrane transporter activity transporter activity transmembrane transporter activity signal sequence binding binding peptide binding	protein localization establishment of protein localization cellular localization nitrogen compound transport transport protein targeting localization SRP-dependent cotranslational protein targeting to membrane protein transmembrane transport cellular macromolecule localization establishment of localization in cell cotranslational protein targeting to membrane establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum protein localization establishment of protein localization cellular localization nitrogen compound transport transport protein targeting localization SRP-dependent cotranslational protein targeting to membrane protein transmembrane transport cellular macromolecule localization establishment of localization in cell cotranslational protein targeting to membrane establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum establishment of protein localization to membrane intracellular protein transmembrane transport organic substance transport intracellular transport localization within membrane protein localization to membrane establishment of localization protein targeting to membrane transmembrane transport establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle SRP-dependent cotranslational protein targeting to membrane, translocation cellular process intracellular protein transport protein targeting to ER	cell periphery plasma membrane membrane cellular anatomical entity
E [auth B]	Preprotein translocase subunit secE	macromolecule transmembrane transporter activity protein transporter activity protein transmembrane transporter activity transporter activity transmembrane transporter activity	protein localization localization establishment of protein localization cellular localization protein targeting cellular macromolecule localization macromolecule localization cellular process establishment of localization nitrogen compound transport transport secretion organic substance transport establishment of protein localization to extracellular region protein localization localization establishment of protein localization cellular localization protein targeting cellular macromolecule localization macromolecule localization cellular process establishment of localization nitrogen compound transport transport secretion organic substance transport establishment of protein localization to extracellular region export from cell protein secretion protein localization to extracellular region secretion by cell protein transport intracellular protein transmembrane transport intracellular transport transmembrane transport protein transmembrane transport establishment of localization in cell intracellular protein transport	cell periphery plasma membrane membrane cellular anatomical entity
F [auth C]	Preprotein translocase subunit secG	-	protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization cellular process	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
D [auth A]	IPR002208	SecY/SEC61-alpha family	Family
D [auth A]	IPR030659	SecY conserved site	Conserved Site
D [auth A]	IPR026593	Protein translocase subunit SecY	Family
D [auth A]	IPR019561	Translocon Sec61/SecY, plug domain	Domain
D [auth A]	IPR023201	SecY domain superfamily	Homologous Superfamily
E [auth B]	IPR008158	Protein translocase SEC61 complex, gamma subunit	Family
E [auth B]	IPR001901	Protein translocase complex, SecE/Sec61-gamma subunit	Family
E [auth B]	IPR023391	Protein translocase SecE domain superfamily	Homologous Superfamily
F [auth C]	IPR016482	Protein transport protein SecG/Sec61-beta/Sbh	Family
F [auth C]	IPR023531	Preprotein translocase subunit SecG	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
D [auth A], E [auth B], F [auth C]	OPM	Transmembrane	Alpha-helical polytopic	General secretory pathway (Sec)	Protein translocase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
D [auth A], E [auth B], F [auth C]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
D [auth A], E [auth B], F [auth C]	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.