Annotations: 3DCL

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF14505	e3dclA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF14505	ECOD (1.6)
A	PF20999	e3dclA2	A: beta barrels	X: cradle loop barrel	H: Uncharacterized protein TM1086 C-terminal domain (From Topology)	T: Uncharacterized protein TM1086 C-terminal domain	F: PF20999	ECOD (1.6)
B	PF14505	e3dclB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF14505	ECOD (1.6)
B	PF20999	e3dclB2	A: beta barrels	X: cradle loop barrel	H: Uncharacterized protein TM1086 C-terminal domain (From Topology)	T: Uncharacterized protein TM1086 C-terminal domain	F: PF20999	ECOD (1.6)
C	PF14505	e3dclC1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF14505	ECOD (1.6)
C	PF20999	e3dclC2	A: beta barrels	X: cradle loop barrel	H: Uncharacterized protein TM1086 C-terminal domain (From Topology)	T: Uncharacterized protein TM1086 C-terminal domain	F: PF20999	ECOD (1.6)
D	PF14505	e3dclD1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF14505	ECOD (1.6)
D	PF20999	e3dclD2	A: beta barrels	X: cradle loop barrel	H: Uncharacterized protein TM1086 C-terminal domain (From Topology)	T: Uncharacterized protein TM1086 C-terminal domain	F: PF20999	ECOD (1.6)
E	PF14505	e3dclE1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF14505	ECOD (1.6)
E	PF20999	e3dclE2	A: beta barrels	X: cradle loop barrel	H: Uncharacterized protein TM1086 C-terminal domain (From Topology)	T: Uncharacterized protein TM1086 C-terminal domain	F: PF20999	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.102.30.10	Mainly Beta	3-layer Sandwich	tm1086 (SG structure) fold	tm1086 (SG structure) domain	CATH (4.3.0)
A	2.40.10.170	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)
A	4.10.1180.10	Few Secondary Structures	Irregular	tm1086 fold	tm1086 domain	CATH (4.3.0)
B	2.102.30.10	Mainly Beta	3-layer Sandwich	tm1086 (SG structure) fold	tm1086 (SG structure) domain	CATH (4.3.0)
B	2.40.10.170	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)
B	4.10.1180.10	Few Secondary Structures	Irregular	tm1086 fold	tm1086 domain	CATH (4.3.0)
C	2.102.30.10	Mainly Beta	3-layer Sandwich	tm1086 (SG structure) fold	tm1086 (SG structure) domain	CATH (4.3.0)
C	2.40.10.170	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)
C	4.10.1180.10	Few Secondary Structures	Irregular	tm1086 fold	tm1086 domain	CATH (4.3.0)
D	2.102.30.10	Mainly Beta	3-layer Sandwich	tm1086 (SG structure) fold	tm1086 (SG structure) domain	CATH (4.3.0)
D	2.40.10.170	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)
D	4.10.1180.10	Few Secondary Structures	Irregular	tm1086 fold	tm1086 domain	CATH (4.3.0)
E	2.102.30.10	Mainly Beta	3-layer Sandwich	tm1086 (SG structure) fold	tm1086 (SG structure) domain	CATH (4.3.0)
E	2.40.10.170	Mainly Beta	Beta Barrel	Thrombin, subunit H		CATH (4.3.0)
E	4.10.1180.10	Few Secondary Structures	Irregular	tm1086 fold	tm1086 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF14505	Domain of unknown function (DUF4438), N-terminal (DUF4438)	Domain of unknown function (DUF4438), N-terminal	-	Family
A, B, C, D, E	PF20999	Domain of unknown function (DUF4438), C-terminal (DUF4438_C)	Domain of unknown function (DUF4438), C-terminal	This is the C-terminal domain of TM_1086 which consists of a 3-layer sandwich.	Domain

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR029433	DUF4438, N-terminal	Domain
A, B, C, D, E	IPR044909	TM_1086 superfamily	Homologous Superfamily
A, B, C, D, E	IPR044910	TM_1086, SG structure domain	Homologous Superfamily
A, B, C, D, E	IPR048399	DUF4438, C-terminal	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.