3D31

ModBC from Methanosarcina acetivorans

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3d31a1	All beta proteins	OB-fold	MOP-like	ABC-transporter additional domain	Sulfate/molybdate ABC transporter, ATP-binding protein	(Methanosarcina acetivorans ) [TaxId: 2214 ],	SCOPe (2.08)
A	d3d31a2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	ABC transporter ATPase domain-like	Sulfate/molybdate ABC transporter, ATP-binding protein	(Methanosarcina acetivorans ) [TaxId: 2214 ],	SCOPe (2.08)
B	d3d31b1	All beta proteins	OB-fold	MOP-like	automated matches	automated matches	(Methanosarcina acetivorans ) [TaxId: 2214 ],	SCOPe (2.08)
B	d3d31b2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	ABC transporter ATPase domain-like	automated matches	(Methanosarcina acetivorans ) [TaxId: 2214 ],	SCOPe (2.08)
C	d3d31c1	Membrane and cell surface proteins and peptides	MetI-like	MetI-like	MetI-like	Sulfate/molybdate ABC transporter, permease protein	(Methanosarcina acetivorans ) [TaxId: 2214 ],	SCOPe (2.08)
D	d3d31d1	Membrane and cell surface proteins and peptides	MetI-like	MetI-like	MetI-like	Sulfate/molybdate ABC transporter, permease protein	(Methanosarcina acetivorans ) [TaxId: 2214 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	TOBE domain-like	8018349	4001963	SCOP2 (2022-06-29)
A	SCOP2 Family	ABC transporter ATPase domain-like	8018348	4003976	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	MOP-like	8057786	3000099	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ABC transporter-like P-loop ATPases	8057785	3002020	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	ABC transporter-like P-loop ATPases	8057785	3002020	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	MOP-like	8057786	3000099	SCOP2B (2022-06-29)
C	SCOP2 Family	Binding-protein-dependent transport system inner membrane component (MetI-like)	8018419	4002760	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	MetI-like	8018420	3001716	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	MetI-like	8018420	3001716	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e3d31A1	A: beta barrels	X: OB-fold	H: MOP-like (From Topology)	T: MOP-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00005	e3d31A3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00005	ECOD (1.6)
B	F_UNCLASSIFIED	e3d31B4	A: beta barrels	X: OB-fold	H: MOP-like (From Topology)	T: MOP-like	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF03459	e3d31B3	A: beta barrels	X: OB-fold	H: MOP-like (From Topology)	T: MOP-like	F: PF03459	ECOD (1.6)
B	PF00005	e3d31B2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00005	ECOD (1.6)
C	PF00528	e3d31C1	A: alpha bundles	X: Type II ABC exporter transmembrane domain fold	H: Type I ABC importer transmembrane domain fold (From Topology)	T: Type I ABC importer transmembrane domain fold	F: PF00528	ECOD (1.6)
D	PF00528	e3d31D1	A: alpha bundles	X: Type II ABC exporter transmembrane domain fold	H: Type I ABC importer transmembrane domain fold (From Topology)	T: Type I ABC importer transmembrane domain fold	F: PF00528	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
A	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
A	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
B	2.40.50.100	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain	CATH (4.3.0)
C	1.10.3720.10	Mainly Alpha	Orthogonal Bundle	MetI-like fold	MetI-like	CATH (4.3.0)
D	1.10.3720.10	Mainly Alpha	Orthogonal Bundle	MetI-like fold	MetI-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03459	TOBE domain (TOBE)	TOBE domain	The TOBE domain [1] (Transport-associated OB) always occurs as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum (eg Swiss:P46930) and sulfate (Swiss: ...	The TOBE domain [1] (Transport-associated OB) always occurs as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum (eg Swiss:P46930) and sulfate (Swiss:P16676). Found in ABC transporters immediately after the ATPase domain.	Domain
A, B	PF00005	ABC transporter (ABC_tran)	ABC transporter	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are comp ...	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664. These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains.	Domain
C, D	PF00528	Binding-protein-dependent transport system inner membrane component (BPD_transp_1)	Binding-protein-dependent transport system inner membrane component	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Sulfate/molybdate ABC transporter, ATP-binding protein	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity	localization transport establishment of localization molybdate ion transport inorganic anion transport	ATPase dependent transmembrane transport complex ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity transporter complex ATP-binding cassette (ABC) transporter complex cell periphery transmembrane transporter complex
C, D	Sulfate/molybdate ABC transporter, permease protein	-	transmembrane transport localization transport cellular process establishment of localization	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR004606	Molybdenum-pterin binding domain	Domain
A, B	IPR003593	AAA+ ATPase domain	Domain
A, B	IPR017871	ABC transporter-like, conserved site	Conserved Site
A, B	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
A, B	IPR008995	Molybdate/tungstate binding, C-terminal	Homologous Superfamily
A, B	IPR003439	ABC transporter-like, ATP-binding domain	Domain
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR005116	Transport-associated OB, type 1	Domain
C, D	IPR000515	ABC transporter type 1, transmembrane domain MetI-like	Domain
C, D	IPR035906	MetI-like superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM	Transmembrane	Alpha-helical polytopic	ABC transporters	Binding-protein-dependent transport system

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	ATP Binding Cassette (ABC) Transporters	ModBC Molybdate ABC Transporter in a trans-inhibited state

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.