3D24

Crystal structure of ligand-binding domain of estrogen-related receptor alpha (ERRalpha) in complex with the peroxisome proliferators-activated receptor coactivator-1alpha box3 peptide (PGC-1alpha)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3d24a1	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Steroid hormone receptor ERR1	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3d24c1	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Steroid hormone receptor ERR1	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8040407	3001442	SCOP2B (2022-06-29)
C	SCOP2 Family	Nuclear receptor ligand-binding domain	8028028	4001384	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Nuclear receptor ligand-binding domain	8040407	3001442	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00104	e3d24A1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: PF00104	ECOD (1.6)
C	PF00104	e3d24C1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: PF00104	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)
C	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00104	Ligand-binding domain of nuclear hormone receptor (Hormone_recep)	Ligand-binding domain of nuclear hormone receptor	This all helical domain is involved in binding the hormone in these receptors.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Steroid hormone receptor ERR1	protein binding binding protein domain specific binding transcription regulator activity DNA-binding transcription factor activity sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding nuclear steroid receptor activity DNA-binding transcription factor activity, RNA polymerase II-specific molecular transducer activity signaling receptor activity double-stranded DNA binding protein binding binding protein domain specific binding transcription regulator activity DNA-binding transcription factor activity sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding nuclear steroid receptor activity DNA-binding transcription factor activity, RNA polymerase II-specific molecular transducer activity signaling receptor activity double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding estrogen response element binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding nuclear receptor activity ligand-activated transcription factor activity steroid binding lipid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II cellular response to stimulus response to organic substance intracellular receptor signaling pathway response to stimulus response to lipid signaling hormone-mediated signaling pathway cell communication cellular response to endogenous stimulus response to hormone response to steroid hormone signal transduction cellular response to organic substance cellular response to steroid hormone stimulus response to organic cyclic compound cellular response to hormone stimulus response to endogenous stimulus cellular response to organic cyclic compound cellular response to chemical stimulus steroid hormone mediated signaling pathway response to chemical cellular response to lipid nuclear receptor signaling pathway intracellular steroid hormone receptor signaling pathway positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle cytoskeleton microtubule cytoskeleton intercellular bridge nucleolus fibrillar center
B, D	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	RNA binding binding organic cyclic compound binding lncRNA binding nucleic acid binding sequence-specific DNA binding DNA binding ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding transcription coactivator activity transcription regulator activity transcription coregulator activity RNA binding binding organic cyclic compound binding lncRNA binding nucleic acid binding sequence-specific DNA binding DNA binding ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding transcription coactivator activity transcription regulator activity transcription coregulator activity nuclear receptor coactivator activity protein-macromolecule adaptor activity molecular adaptor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding protein-containing complex binding chromatin binding chromatin DNA binding nuclear receptor binding	response to stimulus response to activity response to muscle activity regulation of cellular process oxoacid metabolic process regulation of lipid metabolic process positive regulation of biological process positive regulation of cellular metabolic process organic acid metabolic process regulation of primary metabolic process regulation of fatty acid oxidation positive regulation of metabolic process fatty acid oxidation organic substance metabolic process response to stimulus response to activity response to muscle activity regulation of cellular process oxoacid metabolic process regulation of lipid metabolic process positive regulation of biological process positive regulation of cellular metabolic process organic acid metabolic process regulation of primary metabolic process regulation of fatty acid oxidation positive regulation of metabolic process fatty acid oxidation organic substance metabolic process cellular ketone metabolic process regulation of small molecule metabolic process positive regulation of lipid metabolic process small molecule metabolic process lipid oxidation positive regulation of cellular process positive regulation of fatty acid metabolic process fatty acid metabolic process regulation of biological process regulation of cellular ketone metabolic process cellular metabolic process biological regulation carboxylic acid metabolic process lipid modification primary metabolic process regulation of cellular metabolic process positive regulation of fatty acid oxidation cellular lipid metabolic process regulation of fatty acid metabolic process metabolic process cellular process monocarboxylic acid metabolic process positive regulation of small molecule metabolic process regulation of metabolic process lipid metabolic process cellular homeostasis chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis intracellular chemical homeostasis intracellular glucose homeostasis regulation of protein stability regulation of biological quality protein stabilization positive regulation of mitochondrial DNA metabolic process positive regulation of organelle organization positive regulation of cellular component organization regulation of cellular component organization mitochondrial genome maintenance mitochondrial DNA metabolic process nucleobase-containing compound metabolic process cellular component organization positive regulation of macromolecule metabolic process cellular component organization or biogenesis regulation of nucleobase-containing compound metabolic process mitochondrion organization positive regulation of nucleobase-containing compound metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of organelle organization organic cyclic compound metabolic process organelle organization positive regulation of DNA metabolic process regulation of mitochondrion organization macromolecule metabolic process regulation of mitochondrial DNA metabolic process regulation of DNA metabolic process cellular biosynthetic process positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process organic substance biosynthetic process regulation of biosynthetic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process positive regulation of cellular biosynthetic process positive regulation of DNA-binding transcription factor activity RNA metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process regulation of molecular function regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of DNA-templated transcription mRNA processing mRNA metabolic process RNA processing cellular response to stimulus response to oxidative stress cellular response to chemical stimulus cellular response to stress response to stress response to chemical cellular response to oxidative stress cellular response to chemical stress rhythmic process circadian regulation of gene expression circadian rhythm RNA splicing developmental process regulation of muscle tissue development regulation of developmental process tissue development positive regulation of developmental process positive regulation of muscle tissue development anatomical structure development muscle tissue development monosaccharide metabolic process carbohydrate metabolic process small molecule biosynthetic process carbohydrate biosynthetic process hexose metabolic process monosaccharide biosynthetic process gluconeogenesis hexose biosynthetic process glucose metabolic process fat cell differentiation cellular developmental process brown fat cell differentiation cell differentiation nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process positive regulation of phosphate metabolic process purine ribonucleoside triphosphate biosynthetic process positive regulation of nucleotide biosynthetic process regulation of nucleotide biosynthetic process regulation of ATP metabolic process ribonucleotide biosynthetic process purine nucleoside triphosphate biosynthetic process positive regulation of purine nucleotide biosynthetic process regulation of phosphate metabolic process regulation of nucleotide metabolic process phosphate-containing compound metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process positive regulation of phosphorus metabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process ribonucleoside triphosphate biosynthetic process positive regulation of ATP metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process positive regulation of nucleotide metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process purine-containing compound biosynthetic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process carbohydrate derivative biosynthetic process regulation of purine nucleotide biosynthetic process organonitrogen compound metabolic process nucleoside triphosphate biosynthetic process purine-containing compound metabolic process positive regulation of purine nucleotide metabolic process positive regulation of ATP biosynthetic process regulation of ATP biosynthetic process organophosphate metabolic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process response to nutrient levels response to starvation multicellular organismal process digestion regulation of carbohydrate metabolic process regulation of glucose metabolic process positive regulation of gluconeogenesis positive regulation of glucose metabolic process regulation of gluconeogenesis positive regulation of carbohydrate metabolic process regulation of carbohydrate biosynthetic process cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly connective tissue development adipose tissue development animal organ development regulation of circadian rhythm negative regulation of cell population proliferation cell population proliferation regulation of smooth muscle cell proliferation negative regulation of biological process smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation regulation of cell population proliferation negative regulation of cellular process muscle cell proliferation multicellular organismal-level homeostasis energy homeostasis neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death regulation of neuron apoptotic process adaptive thermogenesis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process regulation of multicellular organismal process transcription initiation at RNA polymerase II promoter DNA-templated transcription initiation cellular respiration energy derivation by oxidation of organic compounds respiratory electron transport chain electron transport chain generation of precursor metabolites and energy regulation of generation of precursor metabolites and energy regulation of cellular respiration positive regulation of cellular respiration response to dietary excess	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen nuclear body PML body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR001628	Zinc finger, nuclear hormone receptor-type	Domain
A, C	IPR024178	Estrogen receptor/oestrogen-related receptor	Family
A, C	IPR001723	Nuclear hormone receptor	Family
A, C	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
A, C	IPR027289	Oestrogen-related receptor	Family
A, C	IPR000536	Nuclear hormone receptor, ligand-binding domain	Domain
A, C	IPR035500	Nuclear hormone receptor-like domain superfamily	Homologous Superfamily
B, D	IPR000504	RNA recognition motif domain	Domain
B, D	IPR034605	PGC-1	Family
B, D	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
B, D	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
B, D	IPR034833	PGC-1alpha, RNA recognition motif	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: P11474	osteosarcoma metabolic disease breast carcinoma Diabetes Mellitus, Experimental primary biliary cholangitis sclerosing cholangitis alopecia areata attention deficit hyperactivity disorder, inattentive type leprosy postmenopausal osteoporosis primary ovarian failure skin basal cell carcinoma vitiligo breast cancer Crohn disease osteosarcoma metabolic disease breast carcinoma Diabetes Mellitus, Experimental primary biliary cholangitis sclerosing cholangitis alopecia areata attention deficit hyperactivity disorder, inattentive type leprosy postmenopausal osteoporosis primary ovarian failure skin basal cell carcinoma vitiligo breast cancer Crohn disease hypertensive disorder malignant glioma psoriasis inflammatory bowel disease malignant mesothelioma
B, D	Pharos: Q9UBK2	amyotrophic lateral sclerosis type 2 diabetes mellitus congestive heart failure myocardial infarction Bowen disease of the skin Diabetes Mellitus, Experimental muscular dystrophy, non-human animal lung adenocarcinoma malignant ependymoma maturity-onset diabetes of the young nephrosclerosis atypical teratoid rhabdoid tumor obesity disorder pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer amyotrophic lateral sclerosis type 2 diabetes mellitus congestive heart failure myocardial infarction Bowen disease of the skin Diabetes Mellitus, Experimental muscular dystrophy, non-human animal lung adenocarcinoma malignant ependymoma maturity-onset diabetes of the young nephrosclerosis atypical teratoid rhabdoid tumor obesity disorder pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pituitary cancer schizophrenia hyperglycemia ulcerative colitis large cell medulloblastoma lung cancer malignant glioma medulloblastoma neurodegenerative disease osteosarcoma peripheral nervous system disease gastric carcinoma psoriasis heart failure inborn carbohydrate metabolic disorder malignant colon neoplasm malignant mesothelioma myopathy astrocytic tumor non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm peripheral neuropathy glioblastoma pulmonary emphysema interstitial lung disease

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.