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Crystal structure of the HIV-1 broadly neutralizing antibody 2F5 in complex with the gp41 FP-MPER Hyb3K construct 514GIGALFLGFLGAAGS528KK-Ahx-655KNEQELLELDKWASLWN671 External Resource: Annotation Chains Family Name Domain Identifier Architecture Possible Homology Homology Topology Family Provenance Source (Version) A PF07654 e3d0lA2 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: PF07654 ECOD (1.6) A PF07686 e3d0lA1 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: PF07686 ECOD (1.6) B PF07654 e3d0lB2 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: PF07654 ECOD (1.6) B PF07686 e3d0lB1 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: PF07686 ECOD (1.6)
Chain Protein Name Description Organism Name Gene Allele Name(s) Domain Name(s) Receptor Type Receptor Description Provenance Source 2F5 mAb, anti-gp41 membrane-proximal external region (MPER) L-KAPPA Homo sapiens (human) IGKV1D-13*01, IGKV1-13*02, IGKJ3*01, IGKJ4*01, IGKJ4*02, IGKC*01 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-1_KAPPA IMGT (202416-0) 2F5 mAb, anti-gp41 membrane-proximal external region (MPER) VH-CH1 Homo sapiens (human) IGHV2-5*02, IGHJ6*01, IGHJ6*02, IGHG1*03 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_KAPPA IMGT (202416-0)
Chain Chain Class Chain Subclass Chain Type Antigen Name(s) Provenance Source Light Chain IGKV1 Kappa hyb3k peptide construct SAbDab (2024-04-26) Heavy Chain IGHV2 - hyb3k peptide construct SAbDab (2024-04-26)
Chains Polymer Molecular Function Biological Process Cellular Component 2F5 heavy chain - - - 2F5 light chain - - Hyb3k peptide construct - - -