Annotations: 3CRD

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3crda_	All alpha proteins	DEATH domain	DEATH domain	Caspase recruitment domain, CARD	Raidd CARD domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	CARD-like	8025601	4000308	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DEATH domain	8037980	3000069	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CARD	e3crdA1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: CARD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00619	Caspase recruitment domain (CARD)	Caspase recruitment domain	Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (Pfam:PF00531) domain-like fold .	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	RAIDD	death domain binding protein binding binding protein domain specific binding enzyme binding protease binding protein-macromolecule adaptor activity molecular adaptor activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death positive regulation of apoptotic signaling pathway cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death positive regulation of apoptotic signaling pathway cell communication positive regulation of response to stimulus signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of programmed cell death regulation of apoptotic process biological regulation cell death positive regulation of apoptotic process apoptotic signaling pathway regulation of response to stimulus regulation of cell communication apoptotic process programmed cell death positive regulation of signaling regulation of apoptotic signaling pathway response to mechanical stimulus response to external stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus regulation of cell cycle phase transition negative regulation of biological process negative regulation of cell cycle cell cycle G1/S phase transition intracellular signal transduction negative regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling negative regulation of cell cycle phase transition cell cycle negative regulation of G1/S transition of mitotic cell cycle mitotic G1/S transition checkpoint signaling regulation of cell cycle process DNA integrity checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle DNA damage checkpoint signaling cell cycle phase transition regulation of cell cycle G1/S phase transition DNA damage response, signal transduction by p53 class mediator mitotic cell cycle regulation of mitotic cell cycle negative regulation of cellular process regulation of cell cycle cell cycle process negative regulation of mitotic cell cycle phase transition negative regulation of cell cycle G1/S phase transition signal transduction by p53 class mediator negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling mitotic G1 DNA damage checkpoint signaling DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest signal transduction in response to DNA damage mitotic cell cycle phase transition extrinsic apoptotic signaling pathway via death domain receptors cell surface receptor signaling pathway extrinsic apoptotic signaling pathway	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytoplasm cytosol protein-containing complex catalytic complex peptidase complex endopeptidase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011029	Death-like domain superfamily	Homologous Superfamily
A	IPR037939	Death domain-containing protein CRADD	Family
A	IPR037926	CRADD, Death domain	Domain
A	IPR000488	Death domain	Domain
A	IPR001315	CARD domain	Domain
A	IPR042148	RAIDD, CARD domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P78560	renal cell carcinoma intellectual disability, autosomal recessive 34 chromophobe renal cell carcinoma intellectual disability papillary renal cell carcinoma collecting duct carcinoma sarcomatoid renal cell carcinoma Alzheimer disease Conventional (Clear Cell) Renal Cell Carcinoma lissencephaly spectrum disorders pancreatic ductal adenocarcinoma renal carcinoma tuberculosis autosomal recessive non-syndromic intellectual disability clear cell renal carcinoma renal cell carcinoma intellectual disability, autosomal recessive 34 chromophobe renal cell carcinoma intellectual disability papillary renal cell carcinoma collecting duct carcinoma sarcomatoid renal cell carcinoma Alzheimer disease Conventional (Clear Cell) Renal Cell Carcinoma lissencephaly spectrum disorders pancreatic ductal adenocarcinoma renal carcinoma tuberculosis autosomal recessive non-syndromic intellectual disability clear cell renal carcinoma malignant mesothelioma breast cancer osteoarthritis psoriasis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.