Annotations: 3CMY

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3cmya1	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Homeodomain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3cmya2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00046	e3cmyA1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00046	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00046	Homeodomain (Homeodomain)	Homeodomain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Paired box protein Pax-3	DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription regulator activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific protein binding HMG box domain binding protein domain specific binding	developmental process anatomical structure morphogenesis animal organ development anatomical structure development animal organ morphogenesis cellular process apoptotic process cell death programmed cell death muscle structure development muscle organ development multicellular organism development multicellular organismal process nervous system development developmental process anatomical structure morphogenesis animal organ development anatomical structure development animal organ morphogenesis cellular process apoptotic process cell death programmed cell death muscle structure development muscle organ development multicellular organism development multicellular organismal process nervous system development system development system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex protein-DNA complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle
B	5'-D(DAPDCPDAPDTPDAPDAPDPDCPDGPDAPDTPDTPDAPDC)-3'	-	-	-
C	5'-D(DTPDGPDTPDAPDAPDTPDCPDGPDAPDTPDTPDAPDTPDG)-3'	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR022106	Paired box protein 7, C-terminal	Domain
A	IPR001356	Homeobox domain	Domain
A	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily
A	IPR017970	Homeobox, conserved site	Conserved Site
A	IPR043182	Paired DNA-binding domain	Domain
A	IPR043565	PAX family	Family
A	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A	IPR001523	Paired domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P23760	Waardenburg syndrome alveolar rhabdomyosarcoma Waardenburg syndrome type 1 craniofacial-deafness-hand syndrome sarcoma sinonasal undifferentiated carcinoma Craniofacial Abnormalities spindle cell sarcoma tethered spinal cord syndrome neural tube defect spina bifida Waardenburg syndrome type 3 iniencephaly malignant ependymoma osteosarcoma Waardenburg syndrome alveolar rhabdomyosarcoma Waardenburg syndrome type 1 craniofacial-deafness-hand syndrome sarcoma sinonasal undifferentiated carcinoma Craniofacial Abnormalities spindle cell sarcoma tethered spinal cord syndrome neural tube defect spina bifida Waardenburg syndrome type 3 iniencephaly malignant ependymoma osteosarcoma craniorachischisis diastematomyelia intellectual disability medulloblastoma neurenteric cyst pilocytic astrocytoma cancer rhabdomyosarcoma sinusitis epithelioid sarcoma osteogenesis imperfecta atypical teratoid rhabdoid tumor central nervous system malformation cystic fibrosis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.