3CMV

Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	RecA C-terminal domain-like	8056608	3000958	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	RecA-like P-loop NTPases	8018145	3002019	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	RecA-like P-loop NTPases	8018145	3002019	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	RecA C-terminal domain-like	8056608	3000958	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	RecA-like P-loop NTPases	8018145	3002019	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	RecA C-terminal domain-like	8056608	3000958	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	RecA-like P-loop NTPases	8018145	3002019	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	RecA C-terminal domain-like	8056608	3000958	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	RecA-like P-loop NTPases	8018145	3002019	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	RecA C-terminal domain-like	8056608	3000958	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	RecA-like P-loop NTPases	8018145	3002019	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	RecA C-terminal domain-like	8056608	3000958	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	RecA-like P-loop NTPases	8018145	3002019	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	RecA C-terminal domain-like	8056608	3000958	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	RecA C-terminal domain-like	8056608	3000958	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	RecA-like P-loop NTPases	8018145	3002019	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	recA	e3cmvA5	A: a+b two layers	X: Anti-LPS factor/recA domain (From Topology)	H: Anti-LPS factor/recA domain (From Topology)	T: Anti-LPS factor/recA domain	F: recA	ECOD (1.6)
A	RecA	e3cmvA4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: RecA	ECOD (1.6)
B	recA	e3cmvB5	A: a+b two layers	X: Anti-LPS factor/recA domain (From Topology)	H: Anti-LPS factor/recA domain (From Topology)	T: Anti-LPS factor/recA domain	F: recA	ECOD (1.6)
B	RecA	e3cmvB4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: RecA	ECOD (1.6)
D	recA	e3cmvD5	A: a+b two layers	X: Anti-LPS factor/recA domain (From Topology)	H: Anti-LPS factor/recA domain (From Topology)	T: Anti-LPS factor/recA domain	F: recA	ECOD (1.6)
D	RecA	e3cmvD4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: RecA	ECOD (1.6)
E	recA	e3cmvE3	A: a+b two layers	X: Anti-LPS factor/recA domain (From Topology)	H: Anti-LPS factor/recA domain (From Topology)	T: Anti-LPS factor/recA domain	F: recA	ECOD (1.6)
E	RecA	e3cmvE2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: RecA	ECOD (1.6)
F	recA	e3cmvF5	A: a+b two layers	X: Anti-LPS factor/recA domain (From Topology)	H: Anti-LPS factor/recA domain (From Topology)	T: Anti-LPS factor/recA domain	F: recA	ECOD (1.6)
F	RecA	e3cmvF4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: RecA	ECOD (1.6)
G	recA	e3cmvG5	A: a+b two layers	X: Anti-LPS factor/recA domain (From Topology)	H: Anti-LPS factor/recA domain (From Topology)	T: Anti-LPS factor/recA domain	F: recA	ECOD (1.6)
G	RecA	e3cmvG4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: RecA	ECOD (1.6)
H	recA	e3cmvH5	A: a+b two layers	X: Anti-LPS factor/recA domain (From Topology)	H: Anti-LPS factor/recA domain (From Topology)	T: Anti-LPS factor/recA domain	F: recA	ECOD (1.6)
H	RecA	e3cmvH4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: RecA	ECOD (1.6)
C	recA	e3cmvC5	A: a+b two layers	X: Anti-LPS factor/recA domain (From Topology)	H: Anti-LPS factor/recA domain (From Topology)	T: Anti-LPS factor/recA domain	F: recA	ECOD (1.6)
C	RecA	e3cmvC4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: RecA	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF21096	RecA C-terminal domain (RecA_C)	RecA C-terminal domain	This entry represents a small domain found at the C-terminus of RecA. The recA gene product is a multifunctional enzyme that plays a role in homologous recombination, DNA repair and induction of the SOS response This domain adopts a structure compose ...	This entry represents a small domain found at the C-terminus of RecA. The recA gene product is a multifunctional enzyme that plays a role in homologous recombination, DNA repair and induction of the SOS response This domain adopts a structure composed of a beta hairpin and three alpha helices. It has been shown to bind to dsDNA [1].	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	PF00154	recA bacterial DNA recombination protein (RecA)	recA bacterial DNA recombination protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Protein recA	ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding DNA damage sensor activity small molecule sensor activity ATP-dependent DNA damage sensor activity adenyl ribonucleotide binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding DNA damage sensor activity small molecule sensor activity ATP-dependent DNA damage sensor activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding transcription factor binding protein binding DNA-binding transcription factor binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides single-stranded DNA binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process SOS response postreplication repair cellular biosynthetic process DNA synthesis involved in DNA repair nucleobase-containing compound metabolic process nucleic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process SOS response postreplication repair cellular biosynthetic process DNA synthesis involved in DNA repair nucleobase-containing compound metabolic process nucleic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process DNA repair translesion synthesis cellular metabolic process primary metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process metabolic process macromolecule metabolic process DNA biosynthetic process homologous recombination DNA recombination response to ionizing radiation response to radiation response to abiotic stimulus recombinational repair cell motility	intracellular anatomical structure cytoplasm cellular anatomical entity transferase complex, transferring phosphorus-containing groups DNA polymerase V complex protein-containing complex catalytic complex transferase complex DNA polymerase complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR049261	RecA-like, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR020587	DNA recombination and repair protein RecA, monomer-monomer interface	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR003593	AAA+ ATPase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR020584	DNA recombination/repair protein RecA, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR023400	DNA recombination and repair protein RecA, C-terminal, superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR020588	DNA recombination and repair protein RecA-like, ATP-binding domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR049428	RecA-like, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013765	DNA recombination and repair protein RecA	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.