Annotations: 3CKK

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Methyltransf_4	e3ckkA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: Methyltransf_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.150	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Vaccinia Virus protein VP39	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02390	Putative methyltransferase (Methyltransf_4)	Putative methyltransferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	tRNA (guanine-N(7)-)-methyltransferase	internal mRNA (guanine-N7-)-methyltransferase activity RNA methyltransferase activity catalytic activity, acting on RNA transferase activity, transferring one-carbon groups catalytic activity, acting on a nucleic acid transferase activity methyltransferase activity catalytic activity S-adenosylmethionine-dependent methyltransferase activity mRNA methyltransferase activity tRNA methyltransferase activity tRNA (guanine) methyltransferase activity catalytic activity, acting on a tRNA tRNA (guanine(46)-N7)-methyltransferase activity internal mRNA (guanine-N7-)-methyltransferase activity RNA methyltransferase activity catalytic activity, acting on RNA transferase activity, transferring one-carbon groups catalytic activity, acting on a nucleic acid transferase activity methyltransferase activity catalytic activity S-adenosylmethionine-dependent methyltransferase activity mRNA methyltransferase activity tRNA methyltransferase activity tRNA (guanine) methyltransferase activity catalytic activity, acting on a tRNA tRNA (guanine(46)-N7)-methyltransferase activity RNA binding binding organic cyclic compound binding tRNA binding nucleic acid binding	cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing cellular metabolic process tRNA modification primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing cellular metabolic process tRNA modification primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process RNA modification biosynthetic process ncRNA metabolic process macromolecule modification nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process RNA (guanine-N7)-methylation macromolecule methylation methylation RNA methylation tRNA (guanine-N7)-methylation tRNA methylation regulation of cellular process negative regulation of biological process negative regulation of tRNA metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality tRNA decay RNA catabolic process regulation of biological process negative regulation of metabolic process regulation of cellular metabolic process nucleobase-containing compound catabolic process regulation of gene expression tRNA stabilization regulation of tRNA metabolic process regulation of macromolecule biosynthetic process regulation of metabolic process negative regulation of RNA metabolic process negative regulation of tRNA catabolic process catabolic process macromolecule catabolic process regulation of tRNA stability negative regulation of macromolecule metabolic process negative regulation of catabolic process regulation of biosynthetic process biological regulation negative regulation of RNA catabolic process regulation of macromolecule metabolic process regulation of catabolic process organic cyclic compound catabolic process regulation of cellular biosynthetic process RNA stabilization regulation of tRNA catabolic process regulation of RNA stability organic substance catabolic process	protein-containing complex intracellular anatomical structure catalytic complex methyltransferase complex transferase complex cellular anatomical entity tRNA methyltransferase complex tRNA (m7G46) methyltransferase complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen protein-containing complex intracellular anatomical structure catalytic complex methyltransferase complex transferase complex cellular anatomical entity tRNA methyltransferase complex tRNA (m7G46) methyltransferase complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytoplasm cytosol nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003358	tRNA (guanine-N-7) methyltransferase, Trmb type	Family
A	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A	IPR025763	tRNA (guanine-N-7) methyltransferase catalytic subunit Trm8, eukaryote	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9UBP6	lung adenocarcinoma psoriasis lung cancer malignant glioma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.