Annotations: 3CJH

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02953	e3cjhA1	A: few secondary structure elements	X: Tim10/DDP (From Topology)	H: Tim10/DDP (From Topology)	T: Tim10/DDP	F: PF02953	ECOD (1.6)
C	PF02953	e3cjhC1	A: few secondary structure elements	X: Tim10/DDP (From Topology)	H: Tim10/DDP (From Topology)	T: Tim10/DDP	F: PF02953	ECOD (1.6)
E	PF02953	e3cjhE1	A: few secondary structure elements	X: Tim10/DDP (From Topology)	H: Tim10/DDP (From Topology)	T: Tim10/DDP	F: PF02953	ECOD (1.6)
G	PF02953	e3cjhG1	A: few secondary structure elements	X: Tim10/DDP (From Topology)	H: Tim10/DDP (From Topology)	T: Tim10/DDP	F: PF02953	ECOD (1.6)
I	PF02953	e3cjhI1	A: few secondary structure elements	X: Tim10/DDP (From Topology)	H: Tim10/DDP (From Topology)	T: Tim10/DDP	F: PF02953	ECOD (1.6)
K	PF02953	e3cjhK1	A: few secondary structure elements	X: Tim10/DDP (From Topology)	H: Tim10/DDP (From Topology)	T: Tim10/DDP	F: PF02953	ECOD (1.6)
B	PF02953	e3cjhB1	A: few secondary structure elements	X: Tim10/DDP (From Topology)	H: Tim10/DDP (From Topology)	T: Tim10/DDP	F: PF02953	ECOD (1.6)
D	PF02953	e3cjhD1	A: few secondary structure elements	X: Tim10/DDP (From Topology)	H: Tim10/DDP (From Topology)	T: Tim10/DDP	F: PF02953	ECOD (1.6)
F	PF02953	e3cjhF1	A: few secondary structure elements	X: Tim10/DDP (From Topology)	H: Tim10/DDP (From Topology)	T: Tim10/DDP	F: PF02953	ECOD (1.6)
H	PF02953	e3cjhH1	A: few secondary structure elements	X: Tim10/DDP (From Topology)	H: Tim10/DDP (From Topology)	T: Tim10/DDP	F: PF02953	ECOD (1.6)
J	PF02953	e3cjhJ1	A: few secondary structure elements	X: Tim10/DDP (From Topology)	H: Tim10/DDP (From Topology)	T: Tim10/DDP	F: PF02953	ECOD (1.6)
L	PF02953	e3cjhL1	A: few secondary structure elements	X: Tim10/DDP (From Topology)	H: Tim10/DDP (From Topology)	T: Tim10/DDP	F: PF02953	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.810	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Mitochondrial import inner membrane translocase subunit tim13 like domains	CATH (4.3.0)
C	1.10.287.810	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Mitochondrial import inner membrane translocase subunit tim13 like domains	CATH (4.3.0)
E	1.10.287.810	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Mitochondrial import inner membrane translocase subunit tim13 like domains	CATH (4.3.0)
G	1.10.287.810	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Mitochondrial import inner membrane translocase subunit tim13 like domains	CATH (4.3.0)
I	1.10.287.810	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Mitochondrial import inner membrane translocase subunit tim13 like domains	CATH (4.3.0)
K	1.10.287.810	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Mitochondrial import inner membrane translocase subunit tim13 like domains	CATH (4.3.0)
B	1.10.287.810	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Mitochondrial import inner membrane translocase subunit tim13 like domains	CATH (4.3.0)
D	1.10.287.810	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Mitochondrial import inner membrane translocase subunit tim13 like domains	CATH (4.3.0)
F	1.10.287.810	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Mitochondrial import inner membrane translocase subunit tim13 like domains	CATH (4.3.0)
H	1.10.287.810	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Mitochondrial import inner membrane translocase subunit tim13 like domains	CATH (4.3.0)
J	1.10.287.810	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Mitochondrial import inner membrane translocase subunit tim13 like domains	CATH (4.3.0)
L	1.10.287.810	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Mitochondrial import inner membrane translocase subunit tim13 like domains	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G, I A, C, E, G, I, K	PF02953	Tim10/DDP family zinc finger (zf-Tim10_DDP)	Tim10/DDP family zinc finger	Putative zinc binding domain with four conserved cysteine residues. This domain is found in the human disease protein Swiss:O60220. Members of this family such as Tim9 and Tim10 are involved in mitochondrial protein import [1]. Members of thi ...	Putative zinc binding domain with four conserved cysteine residues. This domain is found in the human disease protein Swiss:O60220. Members of this family such as Tim9 and Tim10 are involved in mitochondrial protein import [1]. Members of this family seem to be localised to the mitochondrial intermembrane space [2].	Domain
B, D, F, H, J B, D, F, H, J, L	PF02953	Tim10/DDP family zinc finger (zf-Tim10_DDP)	Tim10/DDP family zinc finger	Putative zinc binding domain with four conserved cysteine residues. This domain is found in the human disease protein Swiss:O60220. Members of this family such as Tim9 and Tim10 are involved in mitochondrial protein import [1]. Members of thi ...	Putative zinc binding domain with four conserved cysteine residues. This domain is found in the human disease protein Swiss:O60220. Members of this family such as Tim9 and Tim10 are involved in mitochondrial protein import [1]. Members of this family seem to be localised to the mitochondrial intermembrane space [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G, I A, C, E, G, I, K	Mitochondrial import inner membrane translocase subunit TIM13	protein transporter activity transporter activity cation binding ion binding binding metal ion binding small molecule binding	protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of protein localization to mitochondrial membrane protein targeting mitochondrial membrane organization cellular component organization localization cellular macromolecule localization establishment of localization in cell cellular component organization or biogenesis protein insertion into mitochondrial inner membrane protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of protein localization to mitochondrial membrane protein targeting mitochondrial membrane organization cellular component organization localization cellular macromolecule localization establishment of localization in cell cellular component organization or biogenesis protein insertion into mitochondrial inner membrane mitochondrial transport mitochondrion organization membrane organization establishment of protein localization to membrane organic substance transport inner mitochondrial membrane organization intracellular transport localization within membrane protein localization to membrane establishment of localization organelle organization establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion cellular process establishment of protein localization to mitochondrion intracellular protein transport	membrane-bounded organelle mitochondrial protein-containing complex protein-containing complex intracellular anatomical structure mitochondrial intermembrane space mitochondrion membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle transporter complex intracellular organelle lumen organelle envelope lumen intracellular organelle organelle envelope membrane-bounded organelle mitochondrial protein-containing complex protein-containing complex intracellular anatomical structure mitochondrial intermembrane space mitochondrion membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle transporter complex intracellular organelle lumen organelle envelope lumen intracellular organelle organelle envelope mitochondrial intermembrane space protein transporter complex organelle lumen organelle mitochondrial envelope cytoplasm mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle membrane
B, D, F, H, J B, D, F, H, J, L	Mitochondrial import inner membrane translocase subunit TIM8	protein transporter activity transporter activity cation binding ion binding binding metal ion binding small molecule binding	protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of protein localization to mitochondrial membrane protein targeting mitochondrial membrane organization cellular component organization localization cellular macromolecule localization establishment of localization in cell cellular component organization or biogenesis protein insertion into mitochondrial inner membrane protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of protein localization to mitochondrial membrane protein targeting mitochondrial membrane organization cellular component organization localization cellular macromolecule localization establishment of localization in cell cellular component organization or biogenesis protein insertion into mitochondrial inner membrane mitochondrial transport mitochondrion organization membrane organization establishment of protein localization to membrane organic substance transport inner mitochondrial membrane organization intracellular transport localization within membrane protein localization to membrane establishment of localization organelle organization establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion cellular process establishment of protein localization to mitochondrion intracellular protein transport	membrane-bounded organelle mitochondrial protein-containing complex protein-containing complex intracellular anatomical structure mitochondrial intermembrane space mitochondrion membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle transporter complex intracellular organelle lumen organelle envelope lumen intracellular organelle organelle envelope membrane-bounded organelle mitochondrial protein-containing complex protein-containing complex intracellular anatomical structure mitochondrial intermembrane space mitochondrion membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle transporter complex intracellular organelle lumen organelle envelope lumen intracellular organelle organelle envelope mitochondrial intermembrane space protein transporter complex organelle lumen organelle mitochondrial envelope cytoplasm mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G, I A, C, E, G, I, K	IPR004217	Tim10-like	Domain
A, C, E, G, I A, C, E, G, I, K	IPR035427	Tim10-like domain superfamily	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L	IPR004217	Tim10-like	Domain
B, D, F, H, J B, D, F, H, J, L	IPR035427	Tim10-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.