Annotations: 3CH2

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth X]	SCOP2 Family	Papain-like	8066346	4000859	SCOP2 (2022-06-29)
A [auth X]	SCOP2 Superfamily	Cysteine proteinases	8066347	3001808	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth X]	Peptidase_C1	e3ch2X1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: Peptidase_C1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth X]	3.90.70.10	Alpha Beta	Alpha-Beta Complex	Cathepsin B	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth X]	PF00112	Papain family cysteine protease (Peptidase_C1)	Papain family cysteine protease	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth X]	Serine-repeat antigen protein	protein binding binding kinase binding enzyme binding peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity cysteine-type peptidase activity serine hydrolase activity serine-type peptidase activity	exit from host cell biological process involved in interspecies interaction between organisms biological process involved in interaction with host biological process involved in symbiotic interaction regulation of biological process response to stimulus regulation of response to stimulus immune response immune system process biological regulation regulation of immune response regulation of immune system process organic substance metabolic process organonitrogen compound metabolic process exit from host cell biological process involved in interspecies interaction between organisms biological process involved in interaction with host biological process involved in symbiotic interaction regulation of biological process response to stimulus regulation of response to stimulus immune response immune system process biological regulation regulation of immune response regulation of immune system process organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	cell periphery plasma membrane membrane cellular anatomical entity extracellular region extracellular space membrane-bounded organelle host cellular component host intracellular part extracellular organelle host cell cytoplasm part symbiont-containing vacuole host cell cytoplasm symbiont-containing vacuolar space cell periphery plasma membrane membrane cellular anatomical entity extracellular region extracellular space membrane-bounded organelle host cellular component host intracellular part extracellular organelle host cell cytoplasm part symbiont-containing vacuole host cell cytoplasm symbiont-containing vacuolar space host cell part organelle host intracellular region extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth X]	IPR025661	Cysteine peptidase, asparagine active site	Active Site
A [auth X]	IPR013128	Peptidase C1A	Family
A [auth X]	IPR000668	Peptidase C1A, papain C-terminal	Domain
A [auth X]	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
A [auth X]	IPR025660	Cysteine peptidase, histidine active site	Active Site

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.