3CDG

Human CD94/NKG2A in complex with HLA-E

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3cdga1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	Class I MHC, alpha-3 domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3cdga2	Alpha and beta proteins (a+b)	MHC antigen-recognition domain	MHC antigen-recognition domain	MHC antigen-recognition domain	Class I MHC, alpha-1 and alpha-2 domains	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth C]	d3cdgc1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	Class I MHC, alpha-3 domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth C]	d3cdgc2	Alpha and beta proteins (a+b)	MHC antigen-recognition domain	MHC antigen-recognition domain	MHC antigen-recognition domain	Class I MHC, alpha-1 and alpha-2 domains	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth D]	d3cdgd1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	beta2-microglobulin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth D]	d3cdgd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3cdgb1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	beta2-microglobulin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3cdgb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth J]	d3cdgj1	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	CD94	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G [auth E]	d3cdge1	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	CD94	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	MHC antigen-recognition domain	8039640	3000521	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054605	3000071	SCOP2B (2022-06-29)
E [auth C]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054605	3000071	SCOP2B (2022-06-29)
E [auth C]	SCOP2B Superfamily	MHC antigen-recognition domain	8039640	3000521	SCOP2B (2022-06-29)
F [auth D]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8003766	3000071	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8003766	3000071	SCOP2B (2022-06-29)
C [auth J]	SCOP2B Superfamily	C-type lectin-like	8039084	3001261	SCOP2B (2022-06-29)
G [auth E]	SCOP2B Superfamily	C-type lectin-like	8039084	3001261	SCOP2B (2022-06-29)
H [auth F]	SCOP2B Superfamily	C-type lectin-like	8065448	3001261	SCOP2B (2022-06-29)
D [auth K]	SCOP2B Superfamily	C-type lectin-like	8065448	3001261	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07654	e3cdgA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
A	PF00129	e3cdgA2	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: PF00129	ECOD (1.6)
E [auth C]	PF07654	e3cdgC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
E [auth C]	PF00129	e3cdgC2	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: PF00129	ECOD (1.6)
F [auth D]	PF07654	e3cdgD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
B	PF07654	e3cdgB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
C [auth J]	PF00059	e3cdgJ1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
G [auth E]	PF00059	e3cdgE1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
H [auth F]	PF00059	e3cdgF1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)
D [auth K]	PF00059	e3cdgK1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: PF00059	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E [auth C]	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)
E [auth C]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
F [auth D]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C [auth J]	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
G [auth E]	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
H [auth F]	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
D [auth K]	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, E [auth C]	MH1 HLA-E*0101	I-ALPHA	Homo sapiens (human)	HLA-E0101, HLA-E0103	G-DOMAIN G-ALPHA1, G-DOMAIN G-ALPHA2, C-LIKE-DOMAIN C-LIKE	MH	MH1-ALPHA_B2M	IMGT (202416-0)
B, F [auth D]	MH1 HLA-E*0101	B2M	Homo sapiens (human)	B2M01, B2M02	C-LIKE-DOMAIN C-LIKE	MH	MH1-ALPHA_B2M	IMGT (202416-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, E [auth C]	PF00129	Class I Histocompatibility antigen, domains alpha 1 and 2 (MHC_I)	Class I Histocompatibility antigen, domains alpha 1 and 2	-	Domain
A, E [auth C]	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
B, F [auth D]	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
C [auth J], G [auth E]	PF00059	Lectin C-type domain (Lectin_C)	Lectin C-type domain	This family includes both long and short form C-type	Domain
D [auth K], H [auth F]	PF00059	Lectin C-type domain (Lectin_C)	Lectin C-type domain	This family includes both long and short form C-type	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E [auth C]	HLA class I histocompatibility antigen, alpha chain E	binding antigen binding peptide antigen binding peptide binding natural killer cell lectin-like receptor binding protein binding signaling receptor binding beta-2-microglobulin binding protein-containing complex binding T cell receptor binding MHC class I protein binding MHC protein binding	lymphocyte mediated immunity regulation of defense response regulation of immune effector process positive regulation of response to biotic stimulus regulation of response to biotic stimulus positive regulation of leukocyte mediated immunity biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus positive regulation of lymphocyte mediated immunity positive regulation of biological process response to biotic stimulus positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of immune response lymphocyte mediated immunity regulation of defense response regulation of immune effector process positive regulation of response to biotic stimulus regulation of response to biotic stimulus positive regulation of leukocyte mediated immunity biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus positive regulation of lymphocyte mediated immunity positive regulation of biological process response to biotic stimulus positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of immune response response to stress regulation of response to stress positive regulation of natural killer cell mediated immunity innate immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune effector process response to external biotic stimulus natural killer cell mediated immunity positive regulation of immune system process regulation of biological process regulation of natural killer cell mediated immunity positive regulation of innate immune response immune response response to other organism defense response regulation of innate immune response biological regulation defense response to symbiont response to external stimulus immune effector process regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response regulation of immune response multicellular organismal process regulation of cellular process regulation of leukocyte activation negative regulation of biological process regulation of cell activation lymphocyte activation negative regulation of lymphocyte activation negative regulation of natural killer cell activation leukocyte activation negative regulation of cellular process regulation of multicellular organismal process regulation of natural killer cell activation cell activation natural killer cell activation negative regulation of cell activation negative regulation of immune system process cellular process negative regulation of multicellular organismal process negative regulation of leukocyte activation regulation of lymphocyte activation positive regulation of cell population proliferation CD8-positive, alpha-beta T cell activation regulation of alpha-beta T cell activation CD8-positive, alpha-beta T cell proliferation positive regulation of alpha-beta T cell proliferation positive regulation of CD8-positive, alpha-beta T cell activation positive regulation of cell activation T cell activation alpha-beta T cell proliferation lymphocyte proliferation positive regulation of leukocyte activation positive regulation of CD8-positive, alpha-beta T cell proliferation alpha-beta T cell activation regulation of leukocyte proliferation positive regulation of T cell activation cell population proliferation regulation of CD8-positive, alpha-beta T cell proliferation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of alpha-beta T cell activation mononuclear cell proliferation regulation of cell population proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of multicellular organismal process positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion leukocyte proliferation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation regulation of alpha-beta T cell proliferation cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of cell-cell adhesion positive regulation of cellular process T cell proliferation regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of CD8-positive, alpha-beta T cell activation adaptive immune response cellular biosynthetic process interleukin-13 production positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process cytokine production organic substance biosynthetic process regulation of cytokine production positive regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of interleukin-13 production positive regulation of gene expression metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process regulation of interleukin-13 production positive regulation of cellular biosynthetic process humoral immune response antibacterial humoral response antimicrobial humoral response defense response to bacterium response to bacterium negative regulation of lymphocyte proliferation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion negative regulation of mononuclear cell proliferation negative regulation of cell population proliferation antigen processing and presentation antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent antigen processing and presentation of peptide antigen antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I negative regulation of lymphocyte mediated immunity negative regulation of natural killer cell mediated immunity negative regulation of immune response negative regulation of immune effector process leukocyte mediated cytotoxicity negative regulation of response to external stimulus negative regulation of defense response natural killer cell mediated cytotoxicity regulation of cell killing negative regulation of natural killer cell mediated cytotoxicity regulation of natural killer cell mediated cytotoxicity negative regulation of response to biotic stimulus protection from natural killer cell mediated cytotoxicity negative regulation of leukocyte mediated cytotoxicity negative regulation of cell killing negative regulation of response to stimulus regulation of leukocyte mediated cytotoxicity negative regulation of leukocyte mediated immunity cell killing negative regulation of innate immune response immunoglobulin production positive regulation of immunoglobulin production production of molecular mediator of immune response regulation of immunoglobulin production positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response positive regulation of natural killer cell activation immune system development developmental process multicellular organism development natural killer cell tolerance induction anatomical structure development tolerance induction system development antigen processing and presentation of peptide antigen via MHC class Ib antigen processing and presentation via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of exogenous antigen adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains T cell mediated immunity positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of leukocyte mediated cytotoxicity positive regulation of adaptive immune response regulation of T cell mediated immunity T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of adaptive immune response regulation of T cell mediated cytotoxicity positive regulation of T cell mediated immunity positive regulation of cell killing positive regulation of natural killer cell mediated cytotoxicity regulation of natural killer cell cytokine production regulation of cytokine production involved in immune response natural killer cell cytokine production cytokine production involved in immune response positive regulation of natural killer cell cytokine production positive regulation of cytokine production involved in immune response positive regulation of natural killer cell proliferation natural killer cell proliferation regulation of natural killer cell proliferation antigen processing and presentation of endogenous peptide antigen via MHC class Ib regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of interleukin-4 production positive regulation of interleukin-4 production interleukin-4 production positive regulation of TRAIL production TRAIL production regulation of TRAIL production defense response to Gram-positive bacterium positive regulation of acute inflammatory response to antigenic stimulus regulation of myeloid leukocyte mediated immunity regulation of acute inflammatory response to antigenic stimulus regulation of type IIa hypersensitivity myeloid leukocyte mediated immunity inflammatory response to antigenic stimulus positive regulation of hypersensitivity positive regulation of inflammatory response positive regulation of antibody-dependent cellular cytotoxicity antibody-dependent cellular cytotoxicity regulation of type II hypersensitivity positive regulation of immunoglobulin mediated immune response hypersensitivity regulation of inflammatory response regulation of B cell mediated immunity type II hypersensitivity positive regulation of myeloid leukocyte mediated immunity B cell mediated immunity type IIa hypersensitivity regulation of acute inflammatory response inflammatory response positive regulation of acute inflammatory response positive regulation of B cell mediated immunity regulation of immunoglobulin mediated immune response acute inflammatory response regulation of hypersensitivity regulation of inflammatory response to antigenic stimulus acute inflammatory response to antigenic stimulus positive regulation of inflammatory response to antigenic stimulus immunoglobulin mediated immune response positive regulation of type IIa hypersensitivity positive regulation of type II hypersensitivity regulation of antibody-dependent cellular cytotoxicity	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle MHC class I protein complex MHC protein complex protein-containing complex plasma membrane protein complex membrane protein complex MHC class Ib protein complex intracellular anatomical structure intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane cytoplasm organelle membrane endocytic vesicle Golgi membrane Golgi apparatus endomembrane system organelle subcompartment lumenal side of endoplasmic reticulum membrane lumenal side of membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane endosome membrane endosome recycling endosome recycling endosome membrane early endosome early endosome membrane transport vesicle transport vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane coated vesicle
B, F [auth D]	Beta-2-microglobulin	binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding identical protein binding protein binding protein homodimerization activity protein dimerization activity structural molecule activity	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains multicellular organismal process regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity regulation of cellular process response to stimulus T cell cytokine production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of immune response cytokine production leukocyte mediated immunity regulation of immune system process positive regulation of macromolecule metabolic process positive regulation of adaptive immune response positive regulation of T cell cytokine production positive regulation of immune system process regulation of T cell mediated immunity regulation of biological process regulation of cytokine production involved in immune response immune response regulation of adaptive immune response regulation of cellular metabolic process immune effector process regulation of gene expression regulation of leukocyte mediated immunity regulation of response to stimulus positive regulation of production of molecular mediator of immune response positive regulation of multicellular organismal process regulation of immune response regulation of macromolecule biosynthetic process regulation of production of molecular mediator of immune response positive regulation of cytokine production regulation of metabolic process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of cellular metabolic process positive regulation of response to stimulus regulation of T cell cytokine production regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of biosynthetic process regulation of cytokine production positive regulation of immune effector process regulation of multicellular organismal process cytokine production involved in immune response positive regulation of cellular process production of molecular mediator of immune response regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process adaptive immune response regulation of cellular biosynthetic process regulation of lymphocyte mediated immunity positive regulation of gene expression immune system process positive regulation of T cell mediated immunity positive regulation of cytokine production involved in immune response positive regulation of cellular biosynthetic process cellular response to stimulus cellular response to inorganic substance cellular response to metal ion response to inorganic substance cellular response to iron ion cellular response to chemical stimulus response to metal ion response to chemical response to iron ion cellular response to iron(III) ion response to iron(III) ion multicellular organismal-level iron ion homeostasis multicellular organismal-level homeostasis multicellular organismal-level chemical homeostasis regulation of neuron projection development regulation of cellular component organization cellular developmental process cell projection organization negative regulation of biological process cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process cellular component organization or biogenesis negative regulation of cell projection organization system development developmental process plasma membrane bounded cell projection organization negative regulation of cellular component organization regulation of cell projection organization nervous system development negative regulation of neuron projection development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization positive regulation of protein binding regulation of binding positive regulation of binding regulation of protein binding positive regulation of molecular function regulation of molecular function regulation of receptor binding regulation of transferrin receptor binding positive regulation of receptor binding positive regulation of transferrin receptor binding regulation of developmental process regulation of cell differentiation regulation of cell development myeloid cell homeostasis erythrocyte homeostasis regulation of multicellular organismal development hemopoiesis regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation myeloid cell differentiation regulation of hemopoiesis homeostasis of number of cells antigen processing and presentation antigen processing and presentation of peptide antigen via MHC class Ib antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent antigen processing and presentation via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of peptide antigen antigen processing and presentation of exogenous antigen cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation T cell differentiation leukocyte differentiation regulation of localization import into cell positive regulation of cellular component organization transport vesicle-mediated transport localization positive regulation of endocytosis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of transport endocytosis receptor-mediated endocytosis peptide antigen assembly with MHC class I protein complex protein-containing complex organization peptide antigen assembly with MHC protein complex MHC class I protein complex assembly cellular component biogenesis cellular component assembly protein-containing complex assembly antigen processing and presentation of peptide antigen via MHC class I MHC protein complex assembly regulation of neurogenesis regulation of nervous system development negative regulation of neurogenesis negative regulation of nervous system development negative regulation of cell differentiation negative regulation of developmental process negative regulation of cell development negative regulation of multicellular organismal process positive regulation of ferrous iron binding regulation of ferrous iron binding negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of leukocyte mediated cytotoxicity T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of leukocyte mediated cytotoxicity leukocyte mediated cytotoxicity regulation of T cell mediated cytotoxicity regulation of cell killing positive regulation of cell killing cell killing iron ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport metal ion transport system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of smell amyloid fibril formation supramolecular fiber organization protein homotetramerization protein complex oligomerization protein tetramerization protein homooligomerization antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class II negative regulation of receptor binding negative regulation of protein binding negative regulation of binding negative regulation of molecular function peptide antigen assembly with MHC class II protein complex MHC class II protein complex assembly cellular response to nicotine response to nicotine regulation of cellular senescence cellular senescence positive regulation of cellular senescence cellular response to stress response to stress antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I behavior learning or memory cognition regulation of leukocyte activation regulation of cell activation positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion positive regulation of leukocyte activation regulation of cell-cell adhesion positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of leukocyte cell-cell adhesion regulation of lymphocyte activation negative regulation of forebrain neuron differentiation forebrain development regulation of forebrain neuron differentiation central nervous system neuron differentiation head development forebrain generation of neurons animal organ development brain development central nervous system development forebrain neuron differentiation negative regulation of neuron differentiation regulation of neuron differentiation regulation of monoatomic ion transport regulation of iron ion transport regulation of metal ion transport response to organic substance biological process involved in interspecies interaction between organisms response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to molecule of bacterial origin response to biotic stimulus	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex membrane protein complex HFE-transferrin receptor complex receptor complex intracellular anatomical structure cytoplasm cytosol MHC class I protein complex MHC protein complex endosome membrane endosome intracellular vesicle late endosome membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane late endosome organelle membrane phagocytic vesicle phagocytic vesicle membrane endocytic vesicle membrane endocytic vesicle vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome Golgi apparatus membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum Golgi membrane MHC class I peptide loading complex organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen secretory granule secretory vesicle specific granule anchoring junction cell junction focal adhesion cell-substrate junction MHC class II protein complex early endosome endosome lumen early endosome lumen recycling endosome recycling endosome membrane tertiary granule lumen tertiary granule early endosome membrane transport vesicle transport vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane coated vesicle
C [auth J], G [auth E]	Natural killer cells antigen CD94	binding carbohydrate binding protein antigen binding protein binding antigen binding MHC class Ib receptor activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity inhibitory MHC class Ib receptor activity immune receptor activity HLA-E specific inhibitory MHC class Ib receptor activity protein-containing complex binding MHC protein complex binding binding carbohydrate binding protein antigen binding protein binding antigen binding MHC class Ib receptor activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity inhibitory MHC class Ib receptor activity immune receptor activity HLA-E specific inhibitory MHC class Ib receptor activity protein-containing complex binding MHC protein complex binding MHC class I protein complex binding MHC class Ib protein binding signaling receptor binding MHC class Ib protein binding, via antigen binding groove MHC class Ib protein complex binding MHC protein binding	regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of biological process regulation of natural killer cell mediated immunity immune response response to other organism regulation of innate immune response response to external stimulus leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of response to stimulus defense response to other organism positive regulation of defense response natural killer cell mediated cytotoxicity regulation of immune response positive regulation of natural killer cell mediated cytotoxicity regulation of cell killing positive regulation of cell killing regulation of defense response regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity biological process involved in interspecies interaction between organisms regulation of response to external stimulus positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of response to stimulus positive regulation of response to external stimulus response to stress regulation of response to stress innate immune response positive regulation of immune effector process response to external biotic stimulus positive regulation of cellular process positive regulation of innate immune response defense response regulation of leukocyte mediated cytotoxicity biological regulation defense response to symbiont regulation of lymphocyte mediated immunity immune system process cellular process cell killing adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains T cell mediated immunity negative regulation of biological process negative regulation of lymphocyte mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of leukocyte mediated cytotoxicity negative regulation of cellular process negative regulation of cell killing regulation of T cell mediated immunity T cell mediated cytotoxicity regulation of adaptive immune response negative regulation of response to stimulus negative regulation of immune response negative regulation of T cell mediated cytotoxicity negative regulation of immune effector process negative regulation of adaptive immune response adaptive immune response negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of T cell mediated cytotoxicity negative regulation of immune system process negative regulation of leukocyte mediated immunity negative regulation of T cell mediated immunity cellular response to stimulus cell surface receptor signaling pathway signaling signal transduction cell communication immune response-regulating cell surface receptor signaling pathway immune response-activating signaling pathway innate immune response-activating signaling pathway immune response-activating cell surface receptor signaling pathway response to lectin cellular response to lectin activation of innate immune response activation of immune response innate immune response activating cell surface receptor signaling pathway immune response-regulating signaling pathway stimulatory C-type lectin receptor signaling pathway multicellular organismal process regulation of leukocyte activation cell activation regulation of cell activation natural killer cell activation lymphocyte activation leukocyte activation regulation of multicellular organismal process regulation of natural killer cell activation regulation of lymphocyte activation negative regulation of natural killer cell mediated immunity negative regulation of response to external stimulus negative regulation of defense response negative regulation of natural killer cell mediated cytotoxicity negative regulation of response to biotic stimulus negative regulation of innate immune response	protein-containing complex receptor complex cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane
D [auth K], H [auth F]	NKG2-A/NKG2-B type II integral membrane protein	binding carbohydrate binding MHC class Ib receptor activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity inhibitory MHC class Ib receptor activity immune receptor activity HLA-E specific inhibitory MHC class Ib receptor activity protein-containing complex binding MHC protein complex binding MHC class I protein complex binding	regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of biological process regulation of natural killer cell mediated immunity immune response response to other organism regulation of innate immune response response to external stimulus leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of response to stimulus defense response to other organism positive regulation of defense response natural killer cell mediated cytotoxicity regulation of immune response positive regulation of natural killer cell mediated cytotoxicity regulation of cell killing positive regulation of cell killing regulation of defense response regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity biological process involved in interspecies interaction between organisms regulation of response to external stimulus positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of response to stimulus positive regulation of response to external stimulus response to stress regulation of response to stress innate immune response positive regulation of immune effector process response to external biotic stimulus positive regulation of cellular process positive regulation of innate immune response defense response regulation of leukocyte mediated cytotoxicity biological regulation defense response to symbiont regulation of lymphocyte mediated immunity immune system process cellular process cell killing adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains T cell mediated immunity negative regulation of biological process negative regulation of lymphocyte mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of leukocyte mediated cytotoxicity negative regulation of cellular process negative regulation of cell killing regulation of T cell mediated immunity T cell mediated cytotoxicity regulation of adaptive immune response negative regulation of response to stimulus negative regulation of immune response negative regulation of T cell mediated cytotoxicity negative regulation of immune effector process negative regulation of adaptive immune response adaptive immune response negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of T cell mediated cytotoxicity negative regulation of immune system process negative regulation of leukocyte mediated immunity negative regulation of T cell mediated immunity cellular response to stimulus cell surface receptor signaling pathway signaling signal transduction cell communication gamma-delta intraepithelial T cell differentiation developmental process multicellular organismal process cellular developmental process gamma-delta T cell activation hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation gamma-delta T cell differentiation CD8-positive, gamma-delta intraepithelial T cell differentiation T cell activation cell differentiation anatomical structure development T cell differentiation leukocyte differentiation immune response-regulating cell surface receptor signaling pathway natural killer cell inhibitory signaling pathway immune response-inhibiting cell surface receptor signaling pathway immune response-regulating signaling pathway immune response-inhibiting signal transduction immune response-activating signaling pathway innate immune response-activating signaling pathway immune response-activating cell surface receptor signaling pathway response to lectin cellular response to lectin activation of innate immune response activation of immune response innate immune response activating cell surface receptor signaling pathway stimulatory C-type lectin receptor signaling pathway regulation of leukocyte activation regulation of cell activation natural killer cell activation regulation of multicellular organismal process regulation of natural killer cell activation regulation of lymphocyte activation negative regulation of natural killer cell mediated immunity negative regulation of response to external stimulus negative regulation of defense response negative regulation of natural killer cell mediated cytotoxicity negative regulation of response to biotic stimulus negative regulation of innate immune response	protein-containing complex receptor complex cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane
I [auth P], J [auth Q]	leader peptide of HLA class I histocompatibility antigen, alpha chain G	binding antigen binding peptide antigen binding peptide binding identical protein binding protein binding signaling receptor binding CD8 receptor binding protein homodimerization activity protein dimerization activity	regulation of biological process regulation of cellular process regulation of cell cycle process biological regulation negative regulation of biological process negative regulation of cell cycle G0 to G1 transition negative regulation of cell cycle process regulation of G0 to G1 transition negative regulation of G0 to G1 transition negative regulation of cellular process cellular process cell cycle regulation of cell cycle regulation of biological process regulation of cellular process regulation of cell cycle process biological regulation negative regulation of biological process negative regulation of cell cycle G0 to G1 transition negative regulation of cell cycle process regulation of G0 to G1 transition negative regulation of G0 to G1 transition negative regulation of cellular process cellular process cell cycle regulation of cell cycle cell cycle process response to stimulus immune response negative regulation of response to stimulus negative regulation of immune response regulation of response to stimulus negative regulation of immune system process immune system process regulation of immune response regulation of immune system process negative regulation of lymphocyte proliferation multicellular organismal process regulation of leukocyte activation regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation T cell activation lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation negative regulation of mononuclear cell proliferation cell adhesion cell-cell adhesion regulation of multicellular organismal process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation antigen processing and presentation antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent antigen processing and presentation of peptide antigen antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I regulation of immune effector process lymphocyte mediated immunity negative regulation of lymphocyte mediated immunity response to biotic stimulus negative regulation of natural killer cell mediated immunity leukocyte mediated immunity natural killer cell mediated immunity regulation of natural killer cell mediated immunity response to other organism regulation of innate immune response negative regulation of immune effector process response to external stimulus leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity defense response to other organism negative regulation of response to external stimulus negative regulation of defense response natural killer cell mediated cytotoxicity regulation of cell killing negative regulation of natural killer cell mediated cytotoxicity regulation of defense response regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity biological process involved in interspecies interaction between organisms regulation of response to external stimulus negative regulation of response to biotic stimulus protection from natural killer cell mediated cytotoxicity response to stress regulation of response to stress negative regulation of leukocyte mediated cytotoxicity innate immune response response to external biotic stimulus negative regulation of cell killing defense response regulation of leukocyte mediated cytotoxicity defense response to symbiont regulation of lymphocyte mediated immunity negative regulation of leukocyte mediated immunity cell killing negative regulation of innate immune response regulation of leukocyte differentiation cellular developmental process regulation of developmental process negative regulation of dendritic cell differentiation cell development mononuclear cell differentiation regulation of cell differentiation regulation of cell development multicellular organism development cell differentiation anatomical structure development negative regulation of cell differentiation negative regulation of hemopoiesis developmental process regulation of multicellular organismal development negative regulation of leukocyte differentiation hemopoiesis negative regulation of developmental process regulation of dendritic cell differentiation negative regulation of cell development regulation of hemopoiesis dendritic cell differentiation leukocyte differentiation adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains T cell mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of T cell mediated immunity T cell mediated cytotoxicity regulation of adaptive immune response negative regulation of T cell mediated cytotoxicity negative regulation of adaptive immune response adaptive immune response negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of T cell mediated cytotoxicity negative regulation of T cell mediated immunity cellular response to stimulus regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling negative regulation of signal transduction regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction cellular defense response positive regulation of macromolecule biosynthetic process positive regulation of metabolic process cytokine production organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of immune system process regulation of cytokine production involved in immune response cellular metabolic process regulation of cellular metabolic process regulation of gene expression biosynthetic process regulation of macrophage cytokine production positive regulation of production of molecular mediator of immune response positive regulation of multicellular organismal process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response positive regulation of cytokine production regulation of metabolic process positive regulation of macrophage cytokine production cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process organic substance metabolic process positive regulation of biosynthetic process positive regulation of myeloid leukocyte cytokine production involved in immune response regulation of cytokine production positive regulation of immune effector process myeloid leukocyte cytokine production cytokine production involved in immune response positive regulation of cellular process production of molecular mediator of immune response regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process positive regulation of gene expression positive regulation of cytokine production involved in immune response positive regulation of cellular biosynthetic process macrophage cytokine production protein-containing complex organization protein trimerization cellular component organization cellular component biogenesis cellular component assembly protein homotrimerization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis positive regulation of leukocyte mediated immunity positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of response to stimulus positive regulation of immune response positive regulation of leukocyte mediated cytotoxicity positive regulation of adaptive immune response positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated immunity positive regulation of cell killing positive regulation of response to biotic stimulus regulation of natural killer cell cytokine production positive regulation of natural killer cell mediated immunity positive regulation of defense response natural killer cell cytokine production positive regulation of response to external stimulus positive regulation of innate immune response positive regulation of natural killer cell cytokine production lymphocyte differentiation positive regulation of T cell differentiation positive regulation of developmental process positive regulation of cell activation positive regulation of leukocyte activation T cell differentiation positive regulation of T cell activation positive regulation of cell development positive regulation of regulatory T cell differentiation positive regulation of leukocyte cell-cell adhesion positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation positive regulation of hemopoiesis positive regulation of cell differentiation regulation of lymphocyte differentiation positive regulation of cell adhesion regulation of regulatory T cell differentiation regulatory T cell differentiation positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation immune system development tolerance induction dependent upon immune response peripheral B cell tolerance induction B cell tolerance induction B cell mediated immunity peripheral tolerance induction tolerance induction system development immune response-regulating cell surface receptor signaling pathway cell surface receptor signaling pathway immune response-inhibiting cell surface receptor signaling pathway immune response-regulating signaling pathway immune response-inhibiting signal transduction regulation of interleukin-12 production interleukin-12 production positive regulation of interleukin-12 production T cell tolerance induction positive regulation of T cell tolerance induction regulation of tolerance induction positive regulation of tolerance induction regulation of T cell tolerance induction regulation of cellular senescence cellular senescence positive regulation of cellular senescence cellular response to stress positive regulation of epithelial cell apoptotic process positive regulation of endothelial cell apoptotic process positive regulation of programmed cell death regulation of epithelial cell apoptotic process regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process epithelial cell apoptotic process endothelial cell apoptotic process apoptotic process programmed cell death regulation of endothelial cell apoptotic process angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development blood vessel morphogenesis tube development negative regulation of blood vessel morphogenesis negative regulation of angiogenesis vasculature development circulatory system development negative regulation of vasculature development anatomical structure morphogenesis regulation of angiogenesis anatomical structure formation involved in morphogenesis antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of peptide antigen via MHC class Ib antigen processing and presentation via MHC class Ib	membrane-bounded organelle intracellular anatomical structure cis-Golgi network membrane Golgi apparatus membrane intracellular membrane-bounded organelle cellular anatomical entity endomembrane system intracellular organelle bounding membrane of organelle cis-Golgi network organelle cytoplasm organelle membrane membrane-bounded organelle intracellular anatomical structure cis-Golgi network membrane Golgi apparatus membrane intracellular membrane-bounded organelle cellular anatomical entity endomembrane system intracellular organelle bounding membrane of organelle cis-Golgi network organelle cytoplasm organelle membrane cell periphery cell surface plasma membrane external side of plasma membrane side of membrane MHC class I protein complex MHC protein complex protein-containing complex plasma membrane protein complex membrane protein complex intracellular vesicle phagocytic vesicle phagocytic vesicle membrane cytoplasmic vesicle membrane cytoplasmic vesicle vesicle membrane endocytic vesicle membrane vesicle endocytic vesicle Golgi membrane extracellular region extracellular space early endosome endosome organelle subcompartment lumenal side of endoplasmic reticulum membrane lumenal side of membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane endosome membrane recycling endosome recycling endosome membrane early endosome membrane transport vesicle transport vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane coated vesicle filopodium membrane plasma membrane bounded cell projection cell projection actin-based cell projection filopodium plasma membrane region cell projection membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E [auth C]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, E [auth C]	IPR010579	MHC class I, alpha chain, C-terminal	Domain
A, E [auth C]	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
A, E [auth C]	IPR001039	MHC class I alpha chain, alpha1 alpha2 domains	Domain
A, E [auth C]	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
A, E [auth C]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, E [auth C]	IPR007110	Immunoglobulin-like domain	Domain
A, E [auth C]	IPR003597	Immunoglobulin C1-set	Domain
A, E [auth C]	IPR011161	MHC class I-like antigen recognition-like	Domain
A, E [auth C]	IPR037055	MHC class I-like antigen recognition-like superfamily	Homologous Superfamily
B, F [auth D]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B, F [auth D]	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
B, F [auth D]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B, F [auth D]	IPR007110	Immunoglobulin-like domain	Domain
B, F [auth D]	IPR003597	Immunoglobulin C1-set	Domain
B, F [auth D]	IPR015707	Beta-2-Microglobulin	Family
C [auth J], G [auth E]	IPR016187	C-type lectin fold	Homologous Superfamily
C [auth J], G [auth E]	IPR001304	C-type lectin-like	Domain
C [auth J], G [auth E]	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
C [auth J], G [auth E]	IPR033992	Natural killer cell receptor-like, C-type lectin-like domain	Domain
D [auth K], H [auth F]	IPR016187	C-type lectin fold	Homologous Superfamily
D [auth K], H [auth F]	IPR001304	C-type lectin-like	Domain
D [auth K], H [auth F]	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
D [auth K], H [auth F]	IPR033992	Natural killer cell receptor-like, C-type lectin-like domain	Domain
I [auth P], J [auth Q]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
I [auth P], J [auth Q]	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
I [auth P], J [auth Q]	IPR001039	MHC class I alpha chain, alpha1 alpha2 domains	Domain
I [auth P], J [auth Q]	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
I [auth P], J [auth Q]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
I [auth P], J [auth Q]	IPR007110	Immunoglobulin-like domain	Domain
I [auth P], J [auth Q]	IPR003597	Immunoglobulin C1-set	Domain
I [auth P], J [auth Q]	IPR011161	MHC class I-like antigen recognition-like	Domain
I [auth P], J [auth Q]	IPR037055	MHC class I-like antigen recognition-like superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, E [auth C]	Pharos: P13747	parapsoriasis ovarian cancer Parapsoriasis en Plaques plasma cell myeloma schizophrenia astrocytic tumor Crohn disease Duchenne muscular dystrophy juvenile dermatomyositis lung adenocarcinoma malignant mesothelioma pilocytic astrocytoma psoriasis subependymal giant cell astrocytoma Becker muscular dystrophy parapsoriasis ovarian cancer Parapsoriasis en Plaques plasma cell myeloma schizophrenia astrocytic tumor Crohn disease Duchenne muscular dystrophy juvenile dermatomyositis lung adenocarcinoma malignant mesothelioma pilocytic astrocytoma psoriasis subependymal giant cell astrocytoma Becker muscular dystrophy dermatomyositis large cell medulloblastoma lung cancer medulloblastoma osteosarcoma pituitary cancer ulcerative colitis bipolar disorder diabetes mellitus glioblastoma limb-girdle muscular dystrophy lung carcinoma non-small cell lung carcinoma
B, F [auth D]	Pharos: P61769	familial visceral amyloidosis hypoproteinemia, hypercatabolic diffuse large B-cell lymphoma MHC class I deficiency esophageal squamous cell carcinoma kidney disease amyloidosis mature T-cell and NK-cell non-Hodgkin lymphoma autoimmune disease variant ABeta2M amyloidosis Hypergammaglobulinemia prostate cancer heart disease interstitial cystitis lung carcinoma familial visceral amyloidosis hypoproteinemia, hypercatabolic diffuse large B-cell lymphoma MHC class I deficiency esophageal squamous cell carcinoma kidney disease amyloidosis mature T-cell and NK-cell non-Hodgkin lymphoma autoimmune disease variant ABeta2M amyloidosis Hypergammaglobulinemia prostate cancer heart disease interstitial cystitis lung carcinoma acquired metabolic disease ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pilocytic astrocytoma psoriasis Sjogren syndrome glioblastoma juvenile dermatomyositis lung adenocarcinoma lymphatic system disease acute kidney failure pancreatic intraductal papillary-mucinous carcinoma periodic fever syndrome bone marrow disease Down syndrome rheumatoid arthritis subependymal giant cell astrocytoma lung cancer lymphoplasmacytic lymphoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm cancer schizophrenia ulcerative colitis
C [auth J], G [auth E]	Pharos: Q13241	Behcet disease lung adenocarcinoma medulloblastoma pituitary cancer cutaneous lupus erythematosus lung cancer non-small cell lung carcinoma type 1 diabetes mellitus large cell medulloblastoma lung carcinoma osteosarcoma
D [auth K], H [auth F]	Pharos: P26715	Behcet disease dental caries psoriasis
I [auth P], J [auth Q]	Pharos: P17693	asthma malignant glioma ovarian cancer plasma cell myeloma squamous cell lung carcinoma bipolar disorder cervical cancer cutaneous lupus erythematosus inherited susceptibility to asthma liver disease lung carcinoma nasopharyngeal disease pemphigus psoriasis subependymal giant cell astrocytoma asthma malignant glioma ovarian cancer plasma cell myeloma squamous cell lung carcinoma bipolar disorder cervical cancer cutaneous lupus erythematosus inherited susceptibility to asthma liver disease lung carcinoma nasopharyngeal disease pemphigus psoriasis subependymal giant cell astrocytoma astrocytic tumor breast cancer colorectal cancer endogenous depression juvenile dermatomyositis lung adenocarcinoma malignant ependymoma osteosarcoma pilocytic astrocytoma psoriatic arthritis autism spectrum disorder breast carcinoma Crohn disease glioblastoma juvenile idiopathic arthritis lung cancer