3C5R

Crystal Structure of the BARD1 Ankyrin Repeat Domain and Its Functional Consequences

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3c5ra2	Alpha and beta proteins (a+b)	beta-hairpin-alpha-hairpin repeat	Ankyrin repeat	Ankyrin repeat	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3c5ra3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3c5rb1	Alpha and beta proteins (a+b)	beta-hairpin-alpha-hairpin repeat	Ankyrin repeat	Ankyrin repeat	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3c5rb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Ankyrin repeat	8004128	4000366	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Ankyrin repeat	8057709	3000154	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Ankyrin repeat	8057709	3000154	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ank_2	e3c5rA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: Ank_2	ECOD (1.6)
B	Ank_2	e3c5rB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: Ank_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.20	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Ankyrin repeat-containing domain	CATH (4.3.0)
B	1.25.40.20	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Ankyrin repeat-containing domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00023	Ankyrin repeat (Ank)	Ankyrin repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	BRCA1-associated RING domain protein 1	protein heterodimerization activity protein binding binding protein dimerization activity RNA binding organic cyclic compound binding nucleic acid binding kinase binding enzyme binding identical protein binding protein homodimerization activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein protein heterodimerization activity protein binding binding protein dimerization activity RNA binding organic cyclic compound binding nucleic acid binding kinase binding enzyme binding identical protein binding protein homodimerization activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity cation binding ion binding metal ion binding small molecule binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of biological process regulation of cellular process phosphorylation cellular metabolic process biological regulation regulation of cellular metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of biological process regulation of cellular process phosphorylation cellular metabolic process biological regulation regulation of cellular metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process regulation of phosphorylation regulation of phosphorus metabolic process metabolic process phosphorus metabolic process regulation of metabolic process protein localization negative regulation of protein transport regulation of localization establishment of protein localization negative regulation of nucleocytoplasmic transport nitrogen compound transport nucleocytoplasmic transport nuclear transport negative regulation of biological process negative regulation of intracellular protein transport negative regulation of transport localization establishment of localization in cell cellular macromolecule localization nuclear export regulation of protein export from nucleus regulation of intracellular transport organic substance transport negative regulation of establishment of protein localization intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus protein export from nucleus establishment of localization maintenance of location regulation of intracellular protein transport intracellular protein transport maintenance of protein location cellular localization regulation of protein localization transport maintenance of location in cell maintenance of protein location in cell negative regulation of cellular process negative regulation of protein export from nucleus negative regulation of protein localization negative regulation of intracellular transport regulation of transport regulation of establishment of protein localization maintenance of protein location in nucleus regulation of protein transport protein transport regulation of cellular localization macromolecule localization protein localization to organelle maintenance of protein localization in organelle negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death negative regulation of cell cycle cell cycle regulation of cell cycle positive regulation of programmed cell death positive regulation of biological process positive regulation of apoptotic process positive regulation of cellular process response to ionizing radiation cellular response to ionizing radiation response to radiation response to abiotic stimulus cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus catabolic process positive regulation of protein metabolic process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process macromolecule metabolic process organic substance catabolic process regulation of protein catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process homologous recombination DNA recombination DNA metabolic process nucleic acid metabolic process protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal DNA damage checkpoint signaling regulation of cell cycle phase transition signaling regulation of cellular response to stress cell cycle phase transition regulation of signal transduction intracellular signal transduction cell communication regulation of cell cycle checkpoint regulation of intracellular signal transduction regulation of response to stress negative regulation of cell cycle phase transition signal transduction cell cycle process regulation of signaling regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling regulation of response to stimulus signal transduction in response to DNA damage regulation of cell communication regulation of DNA damage checkpoint protein K6-linked ubiquitination protein polyubiquitination DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity DNA replication DNA strand resection involved in replication fork processing replication fork processing DNA repair negative regulation of mRNA 3'-end processing cellular biosynthetic process RNA metabolic process mRNA processing negative regulation of mRNA metabolic process regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process RNA 3'-end processing regulation of nucleobase-containing compound metabolic process RNA processing negative regulation of mRNA processing negative regulation of macromolecule metabolic process regulation of mRNA processing negative regulation of metabolic process mRNA 3'-end processing regulation of mRNA 3'-end processing gene expression mRNA metabolic process macromolecule biosynthetic process biosynthetic process nucleic acid catabolic process regulation of mRNA metabolic process negative regulation of RNA metabolic process multicellular organismal process multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis G2/M transition of mitotic cell cycle mitotic cell cycle negative regulation of mitotic cell cycle mitotic G2/M transition checkpoint regulation of mitotic cell cycle cell cycle G2/M phase transition negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle G2/M phase transition regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process negative regulation of cell cycle G2/M phase transition negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition regulation of DNA repair regulation of DNA metabolic process	membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure BRCA1-C complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity ubiquitin ligase complex catalytic complex transferase complex nuclear ubiquitin ligase complex membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure BRCA1-C complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity ubiquitin ligase complex catalytic complex transferase complex nuclear ubiquitin ligase complex intracellular protein-containing complex BRCA1-BARD1 complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen cytoplasm BRCA1-A complex BRCA1-B complex intracellular non-membrane-bounded organelle cytoplasmic ribonucleoprotein granule supramolecular complex non-membrane-bounded organelle ribonucleoprotein granule

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A, B	IPR039503	BARD1, Zinc finger, RING-type	Domain
A, B	IPR001357	BRCT domain	Domain
A, B	IPR036420	BRCT domain superfamily	Homologous Superfamily
A, B	IPR002110	Ankyrin repeat	Repeat
A, B	IPR017907	Zinc finger, RING-type, conserved site	Conserved Site
A, B	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A, B	IPR001841	Zinc finger, RING-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q99728	neuroblastoma breast carcinoma hereditary breast carcinoma hereditary breast ovarian cancer syndrome ovarian cancer breast cancer malignant ependymoma Malignant neoplasm of breast adrenal cortex carcinoma oligodendroglioma atypical teratoid rhabdoid tumor ovarian carcinoma pancreatic ductal adenocarcinoma dermatomyositis pilocytic astrocytoma neuroblastoma breast carcinoma hereditary breast carcinoma hereditary breast ovarian cancer syndrome ovarian cancer breast cancer malignant ependymoma Malignant neoplasm of breast adrenal cortex carcinoma oligodendroglioma atypical teratoid rhabdoid tumor ovarian carcinoma pancreatic ductal adenocarcinoma dermatomyositis pilocytic astrocytoma uterine cancer large cell medulloblastoma malignant glioma medulloblastoma amyotrophic lateral sclerosis osteosarcoma breast adenocarcinoma ovarian clear cell adenocarcinoma cancer pancreatic intraductal papillary-mucinous carcinoma ductal breast carcinoma in situ primitive neuroectodermal tumor lung carcinoma malignant mesothelioma non-small cell lung carcinoma astrocytic tumor ovarian neoplasm cutaneous lupus erythematosus pancreatic intraductal papillary-mucinous neoplasm glioblastoma subependymal giant cell astrocytoma invasive ductal breast carcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.