3C05

Crystal structure of Acostatin from Agkistrodon Contortrix Contortrix

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3c05a_	Small proteins	Blood coagulation inhibitor (disintegrin)	Blood coagulation inhibitor (disintegrin)	Blood coagulation inhibitor (disintegrin)	automated matches	(Agkistrodon contortrix contortrix ) [TaxId: 8713 ],	SCOPe (2.08)
C	d3c05c_	Small proteins	Blood coagulation inhibitor (disintegrin)	Blood coagulation inhibitor (disintegrin)	Blood coagulation inhibitor (disintegrin)	automated matches	(Agkistrodon contortrix contortrix ) [TaxId: 8713 ],	SCOPe (2.08)
B	d3c05b_	Small proteins	Blood coagulation inhibitor (disintegrin)	Blood coagulation inhibitor (disintegrin)	Blood coagulation inhibitor (disintegrin)	automated matches	(Agkistrodon contortrix contortrix ) [TaxId: 8713 ],	SCOPe (2.08)
D	d3c05d_	Small proteins	Blood coagulation inhibitor (disintegrin)	Blood coagulation inhibitor (disintegrin)	Blood coagulation inhibitor (disintegrin)	automated matches	(Agkistrodon contortrix contortrix ) [TaxId: 8713 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Disintegrin-like	8076444	4003471	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Disintegrin-like	8076445	3000923	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	Disintegrin-like	8076445	3000923	SCOP2B (2022-06-29)
B	SCOP2 Family	Disintegrin-like	8076442	4003471	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Disintegrin-like	8076443	3000923	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Disintegrin-like	8076443	3000923	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Disintegrin_1	e3c05A1	A: few secondary structure elements	X: Blood coagulation inhibitor (disintegrin) (From Topology)	H: Blood coagulation inhibitor (disintegrin) (From Topology)	T: Blood coagulation inhibitor (disintegrin)	F: Disintegrin_1	ECOD (1.6)
C	Disintegrin_1	e3c05C1	A: few secondary structure elements	X: Blood coagulation inhibitor (disintegrin) (From Topology)	H: Blood coagulation inhibitor (disintegrin) (From Topology)	T: Blood coagulation inhibitor (disintegrin)	F: Disintegrin_1	ECOD (1.6)
B	Disintegrin_1	e3c05B1	A: few secondary structure elements	X: Blood coagulation inhibitor (disintegrin) (From Topology)	H: Blood coagulation inhibitor (disintegrin) (From Topology)	T: Blood coagulation inhibitor (disintegrin)	F: Disintegrin_1	ECOD (1.6)
D	Disintegrin_1	e3c05D1	A: few secondary structure elements	X: Blood coagulation inhibitor (disintegrin) (From Topology)	H: Blood coagulation inhibitor (disintegrin) (From Topology)	T: Blood coagulation inhibitor (disintegrin)	F: Disintegrin_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	4.10.70.10	Few Secondary Structures	Irregular	Echistatin	Disintegrin domain	CATH (4.3.0)
C	4.10.70.10	Few Secondary Structures	Irregular	Echistatin	Disintegrin domain	CATH (4.3.0)
B	4.10.70.10	Few Secondary Structures	Irregular	Echistatin	Disintegrin domain	CATH (4.3.0)
D	4.10.70.10	Few Secondary Structures	Irregular	Echistatin	Disintegrin domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00200	Disintegrin (Disintegrin)	Disintegrin	-	Domain
B, D	PF00200	Disintegrin (Disintegrin)	Disintegrin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Disintegrin acostatin alpha	toxin activity	multicellular organismal process regulation of body fluid levels response to stimulus regulation of response to external stimulus negative regulation of biological process regulation of response to wounding regulation of coagulation response to stress regulation of response to stress coagulation regulation of multicellular organismal process regulation of biological quality response to wounding regulation of hemostasis multicellular organismal process regulation of body fluid levels response to stimulus regulation of response to external stimulus negative regulation of biological process regulation of response to wounding regulation of coagulation response to stress regulation of response to stress coagulation regulation of multicellular organismal process regulation of biological quality response to wounding regulation of hemostasis wound healing regulation of biological process negative regulation of response to stimulus negative regulation of wound healing regulation of blood coagulation negative regulation of blood coagulation biological regulation hemostasis response to external stimulus negative regulation of response to wounding blood coagulation negative regulation of hemostasis negative regulation of coagulation regulation of response to stimulus negative regulation of response to external stimulus regulation of wound healing negative regulation of multicellular organismal process cell adhesion cellular process	extracellular region cellular anatomical entity
B, D	Disintegrin acostatin-beta	cation binding ion binding binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein metalloendopeptidase activity hydrolase activity metallopeptidase activity catalytic activity endopeptidase activity toxin activity	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR018358	Disintegrin, conserved site	Conserved Site
A, C	IPR036436	Disintegrin domain superfamily	Homologous Superfamily
A, C	IPR001762	Disintegrin domain	Domain
B, D	IPR034027	Reprolysin domain, adamalysin-type	Domain
B, D	IPR024079	Metallopeptidase, catalytic domain superfamily	Homologous Superfamily
B, D	IPR018358	Disintegrin, conserved site	Conserved Site
B, D	IPR036436	Disintegrin domain superfamily	Homologous Superfamily
B, D	IPR001762	Disintegrin domain	Domain
B, D	IPR002870	Peptidase M12B, propeptide	Domain
B, D	IPR001590	Peptidase M12B, ADAM/reprolysin	Domain

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, C	PCA	Parent Component: GLN RESID: AA0031 PSI-MOD : 2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.