Annotations: 3BXW

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	GH18_SI-CLP	e3bxwB2	A: a+b two layers	X: FKBP-like	H: Chitinase insertion domain (From Topology)	T: Chitinase insertion domain	F: GH18_SI-CLP	ECOD (1.6)
A [auth B]	Glyco_hydro_18	e3bxwB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_18	ECOD (1.6)
B [auth A]	GH18_SI-CLP	e3bxwA2	A: a+b two layers	X: FKBP-like	H: Chitinase insertion domain (From Topology)	T: Chitinase insertion domain	F: GH18_SI-CLP	ECOD (1.6)
B [auth A]	Glyco_hydro_18	e3bxwA3	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_18	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	1.10.8.360	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
A [auth B]	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
A [auth B]	3.10.50.10	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
B [auth A]	1.10.8.360	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
B [auth A]	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
B [auth A]	3.10.50.10	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF00704	Glycosyl hydrolases family 18 (Glyco_hydro_18)	Glycosyl hydrolases family 18	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	Chitinase domain-containing protein 1	chitin binding binding carbohydrate derivative binding oligosaccharide binding carbohydrate binding	carbohydrate metabolic process organic substance metabolic process primary metabolic process metabolic process biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism carbohydrate metabolic process organic substance metabolic process primary metabolic process metabolic process biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus multicellular organismal process regulation of cellular process cellular biosynthetic process negative regulation of biological process regulation of cytokine production involved in inflammatory response negative regulation of cellular metabolic process cytokine production organic substance biosynthetic process regulation of cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of cytokine production involved in inflammatory response negative regulation of macromolecule metabolic process production of molecular mediator involved in inflammatory response regulation of biosynthetic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process cytokine production involved in inflammatory response gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process cellular process regulation of macromolecule biosynthetic process inflammatory response macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process	cellular anatomical entity endomembrane system membrane membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle intracellular organelle organelle trans-Golgi network cytoplasm extracellular region cellular anatomical entity endomembrane system membrane membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle intracellular organelle organelle trans-Golgi network cytoplasm extracellular region lytic vacuole membrane-enclosed lumen vacuolar lumen vacuole lysosomal lumen intracellular organelle lumen organelle lumen lysosome extracellular exosome extracellular vesicle extracellular organelle extracellular space vesicle extracellular membrane-bounded organelle endosome intracellular vesicle cytoplasmic vesicle late endosome nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR011583	Chitinase II	Domain
A [auth B], B [auth A]	IPR029070	Chitinase insertion domain superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR001223	Glycoside hydrolase family 18, catalytic domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], B [auth A]	Pharos: Q9BWS9	bronchitis pancreatic intraductal papillary-mucinous neoplasm chronic obstructive pulmonary disease tuberculosis osteosarcoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.