3BWS

Crystal structure of the leptospiral antigen Lp49

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e3bwsA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF10282	e3bwsA2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF10282	ECOD (1.6)
B	F_UNCLASSIFIED	e3bwsB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF10282	e3bwsB2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF10282	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.3070	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
B	2.60.40.3070	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
B	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF10282	Lactonase, 7-bladed beta-propeller (Lactonase)	Lactonase, 7-bladed beta-propeller	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	protein Lp49	-	regulation of protein maturation positive regulation of protein maturation regulation of cellular process positive regulation of macromolecule biosynthetic process positive regulation of protein processing protein maturation regulation of primary metabolic process positive regulation of metabolic process positive regulation of plasminogen activation regulation of proteolysis proteolysis organic substance biosynthetic process positive regulation of macromolecule metabolic process plasminogen activation regulation of protein maturation positive regulation of protein maturation regulation of cellular process positive regulation of macromolecule biosynthetic process positive regulation of protein processing protein maturation regulation of primary metabolic process positive regulation of metabolic process positive regulation of plasminogen activation regulation of proteolysis proteolysis organic substance biosynthetic process positive regulation of macromolecule metabolic process plasminogen activation zymogen activation regulation of biological process cellular metabolic process regulation of protein metabolic process primary metabolic process regulation of cellular metabolic process regulation of gene expression biosynthetic process positive regulation of proteolysis regulation of protein processing protein processing metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process cellular biosynthetic process positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process organic substance metabolic process positive regulation of biosynthetic process regulation of plasminogen activation protein metabolic process positive regulation of cellular process regulation of biosynthetic process organonitrogen compound metabolic process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process positive regulation of gene expression cellular process positive regulation of cellular biosynthetic process	cell periphery cell outer membrane external encapsulating structure membrane cell envelope outer membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR011045	Nitrous oxide reductase, N-terminal	Homologous Superfamily
A, B	IPR019405	Lactonase, 7-bladed beta propeller	Family
A, B	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.