3BUA

Crystal Structure of TRF2 TRFH domain and APOLLO peptide complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3buaa_	All alpha proteins	Telomeric repeat binding factor (TRF) dimerisation domain	Telomeric repeat binding factor (TRF) dimerisation domain	Telomeric repeat binding factor (TRF) dimerisation domain	TRF2	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3buab_	All alpha proteins	Telomeric repeat binding factor (TRF) dimerisation domain	Telomeric repeat binding factor (TRF) dimerisation domain	Telomeric repeat binding factor (TRF) dimerisation domain	TRF2	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3buac_	All alpha proteins	Telomeric repeat binding factor (TRF) dimerisation domain	Telomeric repeat binding factor (TRF) dimerisation domain	Telomeric repeat binding factor (TRF) dimerisation domain	TRF2	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3buad_	All alpha proteins	Telomeric repeat binding factor (TRF) dimerisation domain	Telomeric repeat binding factor (TRF) dimerisation domain	Telomeric repeat binding factor (TRF) dimerisation domain	TRF2	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Telomeric repeat binding factor (TRF) dimerisation domain	8039524	3000229	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Telomeric repeat binding factor (TRF) dimerisation domain	8039524	3000229	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Telomeric repeat binding factor (TRF) dimerisation domain	8039524	3000229	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Telomeric repeat binding factor (TRF) dimerisation domain	8039524	3000229	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08558	e3buaA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF08558	ECOD (1.6)
B	PF08558	e3buaB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF08558	ECOD (1.6)
C	PF08558	e3buaC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF08558	ECOD (1.6)
D	PF08558	e3buaD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF08558	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.210	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Telomere repeat-binding factor, dimerisation domain	CATH (4.3.0)
B	1.25.40.210	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Telomere repeat-binding factor, dimerisation domain	CATH (4.3.0)
C	1.25.40.210	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Telomere repeat-binding factor, dimerisation domain	CATH (4.3.0)
D	1.25.40.210	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Telomere repeat-binding factor, dimerisation domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF08558	Telomere repeat binding factor (TRF) (TRF)	Telomere repeat binding factor (TRF)	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Telomeric repeat-binding factor 2	sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding telomeric DNA binding protein-containing complex binding double-stranded telomeric DNA binding double-stranded DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding identical protein binding sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding telomeric DNA binding protein-containing complex binding double-stranded telomeric DNA binding double-stranded DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding identical protein binding protein binding protein homodimerization activity protein dimerization activity enzyme binding	regulation of catalytic activity biological regulation positive regulation of catalytic activity regulation of oxidoreductase activity positive regulation of oxidoreductase activity positive regulation of nitric-oxide synthase activity regulation of molecular function positive regulation of molecular function regulation of monooxygenase activity positive regulation of monooxygenase activity regulation of nitric-oxide synthase activity cellular localization anterograde axonal transport transport regulation of catalytic activity biological regulation positive regulation of catalytic activity regulation of oxidoreductase activity positive regulation of oxidoreductase activity positive regulation of nitric-oxide synthase activity regulation of molecular function positive regulation of molecular function regulation of monooxygenase activity positive regulation of monooxygenase activity regulation of nitric-oxide synthase activity cellular localization anterograde axonal transport transport intracellular transport axonal transport establishment of localization localization axo-dendritic transport establishment of localization in cell microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport cellular process microtubule-based movement microtubule-based process regulation of telomere maintenance regulation of cellular component organization regulation of cellular process cellular biosynthetic process telomere organization regulation of DNA biosynthetic process regulation of primary metabolic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening cellular component organization nucleobase-containing compound metabolic process nucleic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process cellular component organization or biogenesis regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process regulation of biological process telomere maintenance via telomerase cellular metabolic process chromosome organization primary metabolic process regulation of cellular metabolic process DNA metabolic process regulation of chromosome organization regulation of macromolecule metabolic process regulation of telomere maintenance via telomere lengthening nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of organelle organization regulation of telomere maintenance via telomerase telomere maintenance regulation of cellular biosynthetic process organic cyclic compound metabolic process organelle organization biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process DNA biosynthetic process regulation of DNA metabolic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process gene expression regulation of gene expression positive regulation of gene expression positive regulation of cellular biosynthetic process cellular response to stimulus cellular response to stress response to stimulus response to stress cellular senescence developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development single strand break repair regulation of cellular response to stress negative regulation of biological process negative regulation of DNA repair regulation of response to stress negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process DNA repair negative regulation of macromolecule metabolic process regulation of single strand break repair negative regulation of response to stimulus negative regulation of metabolic process negative regulation of telomere single strand break repair regulation of DNA repair negative regulation of single strand break repair DNA damage response regulation of response to stimulus telomere single strand break repair negative regulation of DNA metabolic process negative regulation of telomere maintenance negative regulation of chromosome organization negative regulation of cellular component organization negative regulation of organelle organization telomeric loop disassembly regulation of telomeric loop disassembly telomeric D-loop disassembly regulation of telomeric D-loop disassembly negative regulation of telomeric D-loop disassembly negative regulation of telomeric loop disassembly protein localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to chromosome, telomeric region positive regulation of organelle organization positive regulation of cellular component organization positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process positive regulation of chromosome organization positive regulation of DNA metabolic process telomere maintenance in response to DNA damage protection from non-homologous end joining at telomere telomere capping negative regulation of telomere capping regulation of telomere capping protein-containing complex localization axonal transport of messenger ribonucleoprotein complex telomeric loop formation negative regulation of hydrolase activity negative regulation of beta-galactosidase activity regulation of hydrolase activity negative regulation of molecular function negative regulation of catalytic activity regulation of t-circle formation cellular component biogenesis cellular component assembly formation of extrachromosomal circular DNA regulation of cellular component biogenesis negative regulation of t-circle formation telomere maintenance via telomere trimming t-circle formation negative regulation of telomere maintenance via telomerase negative regulation of cellular metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of DNA biosynthetic process negative regulation of telomere maintenance via telomere lengthening negative regulation of biosynthetic process cell cycle regulation of cellular senescence negative regulation of cellular senescence negative regulation of telomere maintenance via semi-conservative replication negative regulation of cell cycle cell cycle DNA replication telomere maintenance via semi-conservative replication regulation of cell cycle process DNA replication nuclear DNA replication regulation of cell cycle cell cycle process DNA-templated DNA replication negative regulation of cell cycle process regulation of telomere maintenance via semi-conservative replication negative regulation of gene expression regulation of nuclease activity negative regulation of exonuclease activity regulation of exonuclease activity negative regulation of nuclease activity regulation of DNA recombination regulation of telomere maintenance via recombination negative regulation of telomere maintenance via recombination negative regulation of DNA recombination at telomere negative regulation of mitotic recombination DNA recombination negative regulation of DNA recombination regulation of DNA recombination at telomere regulation of mitotic recombination telomere maintenance via recombination mitotic recombination	membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleus nuclear protein-containing complex chromosome cellular anatomical entity intracellular membrane-bounded organelle chromosomal region intracellular organelle organelle telomere cap complex intracellular non-membrane-bounded organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleus nuclear protein-containing complex chromosome cellular anatomical entity intracellular membrane-bounded organelle chromosomal region intracellular organelle organelle telomere cap complex intracellular non-membrane-bounded organelle chromosome, telomeric repeat region chromosome, telomeric region shelterin complex non-membrane-bounded organelle nuclear telomere cap complex male germ cell nucleus germ cell nucleus neuron projection cytoplasm axon axon cytoplasm neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection cell projection cytoplasm membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen nuclear body
E, F, G, H	DNA cross-link repair 1B protein	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity beta-lactamase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds protein-containing complex binding nuclease activity hydrolase activity, acting on ester bonds 5'-3' exonuclease activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity beta-lactamase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds protein-containing complex binding nuclease activity hydrolase activity, acting on ester bonds 5'-3' exonuclease activity exonuclease activity DNA exonuclease activity catalytic activity, acting on a nucleic acid 5'-3' DNA exonuclease activity DNA exonuclease activity, producing 5'-phosphomonoesters DNA nuclease activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity, acting on DNA DNA binding organic cyclic compound binding damaged DNA binding nucleic acid binding	telomere organization chromosome organization primary metabolic process DNA metabolic process telomeric loop formation nucleic acid metabolic process telomere maintenance cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization organic substance metabolic process cellular process metabolic process telomere organization chromosome organization primary metabolic process DNA metabolic process telomeric loop formation nucleic acid metabolic process telomere maintenance cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization organic substance metabolic process cellular process metabolic process cellular component organization or biogenesis macromolecule metabolic process cellular response to stimulus telomere maintenance in response to DNA damage response to stimulus cellular response to stress response to stress protection from non-homologous end joining at telomere telomere capping DNA damage response interstrand cross-link repair DNA repair telomere maintenance via telomere lengthening telomeric 3' overhang formation DNA strand elongation double-strand break repair double-strand break repair via nonhomologous end joining	intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen chromosome chromosome, telomeric region chromosomal region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR017357	Telomeric repeat-binding factor 1/2	Family
A, B, C, D	IPR031902	Telomeric repeat-binding factor 2, Rap1-binding domain	Domain
A, B, C, D	IPR030657	Telomeric repeat-binding factor 2	Family
A, B, C, D	IPR017930	Myb domain	Domain
A, B, C, D	IPR013867	Telomere repeat-binding factor, dimerisation domain	Domain
A, B, C, D	IPR036507	Telomere repeat-binding factor, dimerisation domain superfamily	Homologous Superfamily
A, B, C, D	IPR001005	SANT/Myb domain	Domain
E, F, G, H	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Homologous Superfamily
E, F, G, H	IPR011084	DNA repair metallo-beta-lactamase	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q15554	adult T-cell leukemia/lymphoma acute T cell leukemia psoriasis subependymal giant cell astrocytoma osteosarcoma tuberculosis
E, F, G, H	Pharos: Q9H816	dyskeratosis congenita type 1 diabetes mellitus breast carcinoma exocrine pancreatic carcinoma Hashimoto thyroiditis hypothyroidism medulloblastoma osteosarcoma systemic lupus erythematosus ulcerative colitis Crohn disease gastric carcinoma heart disease large cell medulloblastoma myocardial infarction dyskeratosis congenita type 1 diabetes mellitus breast carcinoma exocrine pancreatic carcinoma Hashimoto thyroiditis hypothyroidism medulloblastoma osteosarcoma systemic lupus erythematosus ulcerative colitis Crohn disease gastric carcinoma heart disease large cell medulloblastoma myocardial infarction rheumatoid arthritis systemic sclerosis vitiligo Graves disease Hoyeraal-Hreidarsson syndrome malignant pancreatic neoplasm myositis skin basal cell carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.