3BSU

Hybrid-binding domain of human RNase H1 in complex with 12-mer RNA/DNA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E [auth A]	d3bsua1	Alpha and beta proteins (a+b)	MbtH/L9 domain-like	L9 N-domain-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth A]	d3bsua2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth B]	d3bsub1	Alpha and beta proteins (a+b)	MbtH/L9 domain-like	L9 N-domain-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth B]	d3bsub2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G [auth C]	d3bsuc_	Alpha and beta proteins (a+b)	MbtH/L9 domain-like	L9 N-domain-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H [auth F]	d3bsuf1	Alpha and beta proteins (a+b)	MbtH/L9 domain-like	L9 N-domain-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H [auth F]	d3bsuf2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I [auth G]	d3bsug_	Alpha and beta proteins (a+b)	MbtH/L9 domain-like	L9 N-domain-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J [auth H]	d3bsuh1	Alpha and beta proteins (a+b)	MbtH/L9 domain-like	L9 N-domain-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J [auth H]	d3bsuh2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth A]	SCOP2 Family	N-terminal domain of RNase HI	8084342	4001760	SCOP2 (2022-06-29)
E [auth A]	SCOP2 Superfamily	L9 N-domain-like	8084343	3000338	SCOP2 (2022-06-29)
F [auth B]	SCOP2B Superfamily	L9 N-domain-like	8084343	3000338	SCOP2B (2022-06-29)
G [auth C]	SCOP2B Superfamily	L9 N-domain-like	8084343	3000338	SCOP2B (2022-06-29)
H [auth F]	SCOP2B Superfamily	L9 N-domain-like	8084343	3000338	SCOP2B (2022-06-29)
I [auth G]	SCOP2B Superfamily	L9 N-domain-like	8084343	3000338	SCOP2B (2022-06-29)
J [auth H]	SCOP2B Superfamily	L9 N-domain-like	8084343	3000338	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth A]	Cauli_VI	e3bsuA1	A: a+b two layers	X: L9 N-domain-like	H: L9 N-domain-like (From Topology)	T: L9 N-domain-like	F: Cauli_VI	ECOD (1.6)
F [auth B]	Cauli_VI	e3bsuB1	A: a+b two layers	X: L9 N-domain-like	H: L9 N-domain-like (From Topology)	T: L9 N-domain-like	F: Cauli_VI	ECOD (1.6)
G [auth C]	Cauli_VI	e3bsuC1	A: a+b two layers	X: L9 N-domain-like	H: L9 N-domain-like (From Topology)	T: L9 N-domain-like	F: Cauli_VI	ECOD (1.6)
H [auth F]	Cauli_VI	e3bsuF1	A: a+b two layers	X: L9 N-domain-like	H: L9 N-domain-like (From Topology)	T: L9 N-domain-like	F: Cauli_VI	ECOD (1.6)
I [auth G]	Cauli_VI	e3bsuG1	A: a+b two layers	X: L9 N-domain-like	H: L9 N-domain-like (From Topology)	T: L9 N-domain-like	F: Cauli_VI	ECOD (1.6)
J [auth H]	Cauli_VI	e3bsuH1	A: a+b two layers	X: L9 N-domain-like	H: L9 N-domain-like (From Topology)	T: L9 N-domain-like	F: Cauli_VI	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth A]	3.40.970.10	Alpha Beta	3-Layer(aba) Sandwich	Ribonuclease HI	Chain A	CATH (4.3.0)
F [auth B]	3.40.970.10	Alpha Beta	3-Layer(aba) Sandwich	Ribonuclease HI	Chain A	CATH (4.3.0)
G [auth C]	3.40.970.10	Alpha Beta	3-Layer(aba) Sandwich	Ribonuclease HI	Chain A	CATH (4.3.0)
H [auth F]	3.40.970.10	Alpha Beta	3-Layer(aba) Sandwich	Ribonuclease HI	Chain A	CATH (4.3.0)
I [auth G]	3.40.970.10	Alpha Beta	3-Layer(aba) Sandwich	Ribonuclease HI	Chain A	CATH (4.3.0)
J [auth H]	3.40.970.10	Alpha Beta	3-Layer(aba) Sandwich	Ribonuclease HI	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], J [auth H]	PF01693	Caulimovirus viroplasmin (Cauli_VI)	Caulimovirus viroplasmin	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D], C [auth I]	RNA (5'-R(GPAPCPAPCPCPUPGPAPUPUPC)-3')	-	-	-
E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], J [auth H]	Ribonuclease H1	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding organic cyclic compound binding nucleic acid binding nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding organic cyclic compound binding nucleic acid binding nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters RNA-DNA hybrid ribonuclease activity RNA endonuclease activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters RNA binding	catabolic process RNA metabolic process primary metabolic process nucleic acid metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process organic substance catabolic process catabolic process RNA metabolic process primary metabolic process nucleic acid metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process organic substance catabolic process RNA catabolic process DNA replication, removal of RNA primer DNA metabolic process DNA replication	intracellular anatomical structure cytoplasm cellular anatomical entity
B [auth E], D [auth J]	DNA (5'-D(DGPDAPDAPDTPDCPDAPDGPDGP(5IU)PDGPDTPDC)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], J [auth H]	IPR036397	Ribonuclease H superfamily	Homologous Superfamily
E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], J [auth H]	IPR037056	Ribonuclease H1, N-terminal domain superfamily	Homologous Superfamily
E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], J [auth H]	IPR002156	Ribonuclease H domain	Domain
E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], J [auth H]	IPR011320	Ribonuclease H1, N-terminal	Domain
E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], J [auth H]	IPR009027	Large ribosomal subunit protein bL9/RNase H1, N-terminal	Homologous Superfamily
E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], J [auth H]	IPR017067	Ribonuclease H1, eukaryote	Family
E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], J [auth H]	IPR012337	Ribonuclease H-like superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], E [auth A], F [auth B], G [auth C], H [auth F], I [auth G], J [auth H]	Pharos: O60930	progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2 progressive external ophthalmoplegia adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy muscle tissue disease osteosarcoma lung cancer muscular disease ovarian cancer psoriasis Mitochondrial Diseases myopathy

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.