Annotations: 3BRG

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d3brgc2	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	automated matches	automated matches	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d3brgc1	All beta proteins	beta-Trefoil	DNA-binding protein LAG-1 (CSL)	automated matches	automated matches	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	PF20144	e3brgC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF20144	ECOD (1.6)
C	PF09271	e3brgC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: PF09271	ECOD (1.6)
C	PF09270	e3brgC3	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: PF09270	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	2.60.40.1450	Mainly Beta	Sandwich	Immunoglobulin-like	LAG1, DNA binding domain	CATH (4.3.0)
C	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C	PF20144	TIG domain (TIG_SUH)	TIG domain	This entry represents a TIG-like domain found in the suppressor of hairless protein.	Domain
C	PF09270	Beta-trefoil DNA-binding domain (BTD)	Beta-trefoil DNA-binding domain	Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and ...	Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR) [1].	Domain
C	PF09271	LAG1, DNA binding (LAG1-DNAbind)	LAG1, DNA binding	Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding [1]. Th ...	Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding [1]. This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DNA (5'-D(DAPDAPDTPDCPDTPDTPDTPDCPDCPDCPDAPDCPDAPDGP*DT)-3')	-	-	-
B	DNA (5'-D(DTPDTPDAPDCPDTPDGPDTPDGPDGPDGPDAPDAPDAPDGP*DA)-3')	-	-	-
C	Recombining binding protein suppressor of hairless	sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity transcription factor binding protein binding DNA-binding transcription factor binding sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity transcription factor binding protein binding DNA-binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding chromatin binding	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cardiac chamber morphogenesis heart morphogenesis ventricular septum development anatomical structure morphogenesis cardiac septum development cardiac septum morphogenesis developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cardiac chamber morphogenesis heart morphogenesis ventricular septum development anatomical structure morphogenesis cardiac septum development cardiac septum morphogenesis ventricular septum morphogenesis cardiac chamber development animal organ morphogenesis cardiac ventricle development atrioventricular canal development heart formation specification of animal organ identity pattern specification process regionalization anatomical structure formation involved in morphogenesis secondary heart field specification animal organ formation heart field specification cellular developmental process hemopoiesis cell differentiation cell development cellular process blood vessel morphogenesis tube development artery development vasculature development tube morphogenesis artery morphogenesis blood vessel development biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus negative regulation of cell population proliferation regulation of biological process regulation of stem cell proliferation cell population proliferation regulation of cellular process biological regulation negative regulation of biological process negative regulation of stem cell proliferation stem cell proliferation regulation of cell population proliferation negative regulation of cellular process regulation of cell adhesion cell adhesion involved in heart morphogenesis cell adhesion regulation of cell adhesion involved in heart morphogenesis skin development gland development sebaceous gland development epithelium development respiratory tube development lung epithelium development tissue development epithelial cell differentiation lung epithelial cell differentiation lung cell differentiation lung development respiratory system development club cell differentiation cell fate commitment somatic stem cell population maintenance maintenance of cell number stem cell population maintenance negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular response to stimulus cell surface receptor signaling pathway signaling cell communication Notch signaling pathway signal transduction endocardial cushion morphogenesis mesenchyme development endocardial cushion development cardiac epithelial to mesenchymal transition epithelial to mesenchymal transition involved in endocardial cushion formation mesenchyme morphogenesis epithelial to mesenchymal transition endocardial cushion formation tissue morphogenesis mesenchymal cell differentiation ventricular cardiac muscle tissue morphogenesis striated muscle tissue development muscle structure development ventricular cardiac muscle tissue development ventricular trabecula myocardium morphogenesis muscle tissue development muscle organ development cardiac muscle tissue development muscle tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis heart trabecula morphogenesis trabecula morphogenesis muscle organ morphogenesis regulation of reproductive process reproductive process regulation of development, heterochronic regulation of developmental process regulation of cell differentiation regulation of timing of cell differentiation determination of heart left/right asymmetry determination of bilateral symmetry determination of left/right symmetry left/right pattern formation specification of symmetry somitogenesis chordate embryonic development segmentation anterior/posterior pattern specification embryo development embryo development ending in birth or egg hatching somite development nervous system development generation of neurons neurogenesis neuron differentiation epidermal cell differentiation epidermis development cell fate specification epidermal cell fate specification endocardium development endocardium morphogenesis positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus positive regulation of signal transduction regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction positive regulation of BMP signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus BMP signaling pathway enzyme-linked receptor protein signaling pathway positive regulation of cellular process cellular response to BMP stimulus regulation of signaling regulation of BMP signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway response to BMP regulation of response to stimulus regulation of cell communication transforming growth factor beta receptor superfamily signaling pathway response to growth factor positive regulation of signaling positive regulation of cell population proliferation positive regulation of cell proliferation involved in heart morphogenesis cell proliferation involved in heart morphogenesis regulation of cell proliferation involved in heart morphogenesis epithelial cell proliferation molting cycle process hair cycle developmental maturation anatomical structure maturation skin epidermis development hair follicle development molting cycle hair cycle process hair follicle maturation endothelium development morphogenesis of an endothelium endothelial tube morphogenesis morphogenesis of an epithelium blood vessel lumenization epithelial tube morphogenesis cardiac muscle cell myoblast differentiation cardiocyte differentiation cardioblast differentiation stem cell differentiation myoblast differentiation regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of cold-induced thermogenesis homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis regulation of multicellular organismal process negative regulation of multicellular organismal process ossification regulation of ossification negative regulation of ossification aorta morphogenesis aorta development dorsal aorta morphogenesis dorsal aorta development outflow tract morphogenesis regulation of ephrin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway positive regulation of ephrin receptor signaling pathway ephrin receptor signaling pathway positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of gene expression positive regulation of cellular biosynthetic process regulation of growth regulation of cardiac muscle tissue growth developmental growth cardiac muscle cell proliferation organ growth positive regulation of developmental process positive regulation of cardiac muscle cell proliferation regulation of organ growth regulation of heart growth regulation of cardiac muscle cell proliferation muscle cell proliferation cardiac muscle tissue growth positive regulation of developmental growth striated muscle cell proliferation positive regulation of heart growth heart growth regulation of multicellular organismal development regulation of developmental growth positive regulation of organ growth growth positive regulation of growth positive regulation of cardiac muscle tissue growth positive regulation of multicellular organismal process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of transcription of Notch receptor target positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process head development forebrain development endocrine system development pituitary gland development brain development diencephalon development central nervous system development heart valve development pulmonary valve development semi-lunar valve development regulation of generation of precursor metabolites and energy generation of precursor metabolites and energy immune response immune system process inflammatory response inflammatory response to antigenic stimulus negative regulation of developmental process negative regulation of cell differentiation heart induction developmental induction regulation of anatomical structure morphogenesis regulation of animal organ morphogenesis positive regulation of animal organ morphogenesis regulation of animal organ formation organ induction regulation of heart morphogenesis embryonic heart tube development embryonic heart tube morphogenesis heart looping embryonic organ development embryonic organ morphogenesis embryonic morphogenesis keratinocyte differentiation B cell activation cell activation mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation leukocyte differentiation labyrinthine layer blood vessel development placenta blood vessel development placenta development labyrinthine layer development in utero embryonic development embryonic placenta development myeloid leukocyte differentiation myeloid dendritic cell activation myeloid leukocyte activation myeloid cell differentiation myeloid dendritic cell differentiation dendritic cell differentiation angiogenesis humoral immune response endothelial cell fate commitment epithelial cell fate commitment endothelial cell fate specification blood vessel endothelial cell differentiation blood vessel endothelial cell fate commitment endothelial cell differentiation blood vessel endothelial cell fate specification positive regulation of epithelial cell proliferation regulation of epithelial cell proliferation arterial endothelial cell fate commitment arterial endothelial cell differentiation cardiac left ventricle morphogenesis blood vessel remodeling tissue remodeling positive regulation of ERBB signaling pathway regulation of ERBB signaling pathway ERBB signaling pathway aortic valve development sensory organ development hair cell differentiation auditory receptor cell fate commitment inner ear development mechanoreceptor differentiation ear development inner ear receptor cell fate commitment neuron fate commitment inner ear auditory receptor cell differentiation inner ear receptor cell differentiation	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex transcription regulator complex cytoplasm MAML1-RBP-Jkappa- ICN1 complex nucleoplasm transcription repressor complex protein-DNA complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C	IPR040159	Suppressor of hairless-like	Family
C	IPR036358	Beta-trefoil domain superfamily	Homologous Superfamily
C	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C	IPR037095	RBP-J/Cbf11, DNA binding domain superfamily	Homologous Superfamily
C	IPR014756	Immunoglobulin E-set	Homologous Superfamily
C	IPR015350	Beta-trefoil DNA-binding domain	Domain
C	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
C	IPR015351	RBP-J/Cbf11/Cbf12, DNA binding	Domain
C	IPR038007	RBP-Jkappa, IPT domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.