3BOY

Crystal structure of the HutP antitermination complex bound to the HUT mRNA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth A]	d3boya_	Alpha and beta proteins (a+b)	Hut operon positive regulatory protein HutP	Hut operon positive regulatory protein HutP	Hut operon positive regulatory protein HutP	Hut operon positive regulatory protein HutP	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
C [auth B]	d3boyb_	Alpha and beta proteins (a+b)	Hut operon positive regulatory protein HutP	Hut operon positive regulatory protein HutP	Hut operon positive regulatory protein HutP	Hut operon positive regulatory protein HutP	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)
D [auth C]	d3boyc_	Alpha and beta proteins (a+b)	Hut operon positive regulatory protein HutP	Hut operon positive regulatory protein HutP	Hut operon positive regulatory protein HutP	Hut operon positive regulatory protein HutP	(Bacillus subtilis ) [TaxId: 1423 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth A]	SCOP2B Superfamily	Hut operon positive regulatory protein HutP	8033212	3001538	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Hut operon positive regulatory protein HutP	8033212	3001538	SCOP2B (2022-06-29)
D [auth C]	SCOP2B Superfamily	Hut operon positive regulatory protein HutP	8033212	3001538	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	HutP	e3boyA1	A: a+b three layers	X: Hut operon positive regulatory protein HutP (From Topology)	H: Hut operon positive regulatory protein HutP (From Topology)	T: Hut operon positive regulatory protein HutP	F: HutP	ECOD (1.6)
C [auth B]	HutP	e3boyB1	A: a+b three layers	X: Hut operon positive regulatory protein HutP (From Topology)	H: Hut operon positive regulatory protein HutP (From Topology)	T: Hut operon positive regulatory protein HutP	F: HutP	ECOD (1.6)
D [auth C]	HutP	e3boyC1	A: a+b three layers	X: Hut operon positive regulatory protein HutP (From Topology)	H: Hut operon positive regulatory protein HutP (From Topology)	T: Hut operon positive regulatory protein HutP	F: HutP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth A]	3.40.1510.10	Alpha Beta	3-Layer(aba) Sandwich	Hut operon positive regulatory protein HutP	Hut operon regulatory protein HutP	CATH (4.3.0)
C [auth B]	3.40.1510.10	Alpha Beta	3-Layer(aba) Sandwich	Hut operon positive regulatory protein HutP	Hut operon regulatory protein HutP	CATH (4.3.0)
D [auth C]	3.40.1510.10	Alpha Beta	3-Layer(aba) Sandwich	Hut operon positive regulatory protein HutP	Hut operon regulatory protein HutP	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth A], C [auth B], D [auth C]	PF09021	HutP (HutP)	HutP	The HutP protein family regulates the expression of Bacillus 'hut' structural genes by an anti-termination complex, which recognises three UAG triplet units, separated by four non-conserved nucleotides on the RNA terminator region. L-histidine and Mg ...	The HutP protein family regulates the expression of Bacillus 'hut' structural genes by an anti-termination complex, which recognises three UAG triplet units, separated by four non-conserved nucleotides on the RNA terminator region. L-histidine and Mg2+ ions are also required. These proteins exhibit the structural elements of alpha/beta proteins, arranged in the order: alpha-alpha-beta-alpha-alpha-beta-beta-beta in the primary structure, and the four antiparallel beta-strands form a beta-sheet in the order beta1-beta2-beta3-beta4, with two alpha-helices each on the front (alpha1 and alpha2) and at the back (alpha3 and alpha4) of the beta-sheet [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D]	5'-R(UPUPUPAPGPUPUPUPUPUPAPGPUPUPUPUPUPAPGPUPUPU)-3'	-	-	-
B [auth A], C [auth B], D [auth C]	Hut operon positive regulatory protein	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding	regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process organonitrogen compound metabolic process oxoacid metabolic process carboxylic acid metabolic process small molecule metabolic process histidine metabolic process organic acid metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth A], C [auth B], D [auth C]	IPR023552	Hut operon regulatory protein HutP, bacillales	Family
B [auth A], C [auth B], D [auth C]	IPR015111	Hut operon regulatory protein HutP	Family
B [auth A], C [auth B], D [auth C]	IPR036482	Hut operon regulatory protein HutP superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.