3BJ4

The KCNQ1 (Kv7.1) C-terminus, a multi-tiered scaffold for subunit assembly and protein interaction

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	KCNQ1 coiled-coil tetramerization domain	8055722	3002299	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	KCNQ1 coiled-coil tetramerization domain	8055722	3002299	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03520	KCNQ voltage-gated potassium channel (KCNQ_channel)	KCNQ voltage-gated potassium channel	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Potassium voltage-gated channel subfamily KQT member 1	monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization delayed rectifier potassium channel activity protein phosphatase binding phosphatase binding protein phosphatase 1 binding protein binding binding enzyme binding calmodulin binding scaffold protein binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding transmembrane transporter binding protein kinase A binding protein kinase A regulatory subunit binding voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization protein kinase A catalytic subunit binding kinase binding protein kinase binding outward rectifier potassium channel activity	developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development regulation of localization regulation of cellular process negative regulation of ion transmembrane transporter activity negative regulation of potassium ion transmembrane transporter activity negative regulation of biological process negative regulation of transport localization developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development regulation of localization regulation of cellular process negative regulation of ion transmembrane transporter activity negative regulation of potassium ion transmembrane transporter activity negative regulation of biological process negative regulation of transport localization negative regulation of voltage-gated potassium channel activity negative regulation of cation transmembrane transport monoatomic cation transport regulation of potassium ion transmembrane transporter activity regulation of biological process regulation of monoatomic ion transport inorganic ion transmembrane transport regulation of potassium ion transmembrane transport establishment of localization regulation of cation channel activity inorganic cation transmembrane transport transmembrane transport regulation of molecular function regulation of transmembrane transport potassium ion transport regulation of potassium ion transport negative regulation of cation channel activity transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport regulation of transmembrane transporter activity potassium ion transmembrane transport regulation of monoatomic ion transmembrane transport negative regulation of transmembrane transport metal ion transport regulation of transporter activity monoatomic cation transmembrane transport negative regulation of monoatomic ion transmembrane transport negative regulation of cellular process monoatomic ion transport regulation of metal ion transport negative regulation of potassium ion transport regulation of monoatomic ion transmembrane transporter activity regulation of transport biological regulation negative regulation of transporter activity negative regulation of molecular function negative regulation of potassium ion transmembrane transport cellular process regulation of monoatomic cation transmembrane transport multicellular organismal process system process secretion digestive system process acid secretion gastric acid secretion digestion gastrin-induced gastric acid secretion heart process regulation of heart contraction regulation of system process positive regulation of biological process positive regulation of heart rate positive regulation of blood circulation positive regulation of heart contraction circulatory system process regulation of blood circulation positive regulation of multicellular organismal process regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate heart development multicellular organism development circulatory system development system development regulation of blood pressure monoatomic anion transport iodide transport inorganic anion transport corticosterone secretion signaling steroid hormone secretion organic hydroxy compound transport hormone secretion cell communication secretion by cell signal release regulation of hormone levels organic substance transport lipid localization export from cell cell-cell signaling lipid transport endocrine hormone secretion endocrine process lipid export from cell macromolecule localization hormone transport glucocorticoid secretion corticosteroid hormone secretion intestinal absorption cardiac muscle cell membrane repolarization membrane repolarization regulation of membrane repolarization ventricular cardiac muscle cell membrane repolarization regulation of cardiac muscle cell membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization regulation of membrane potential inner ear receptor cell development cellular developmental process epidermis development cell development epithelial cell differentiation hair cell differentiation neurogenesis neuron differentiation cell differentiation mechanoreceptor differentiation epithelium development epidermal cell differentiation inner ear auditory receptor cell differentiation nervous system development tissue development inner ear receptor cell differentiation generation of neurons neuron development auditory receptor cell development monosaccharide metabolic process carbohydrate metabolic process organic substance metabolic process hexose metabolic process small molecule metabolic process metabolic process primary metabolic process glucose metabolic process action potential membrane repolarization during action potential behavior rhythmic behavior renal system process renal absorption cardiac muscle cell action potential involved in contraction membrane repolarization during cardiac muscle cell action potential cardiac muscle contraction striated muscle contraction actin filament-based process cardiac muscle cell contraction ventricular cardiac muscle cell action potential actin filament-based movement muscle contraction muscle system process membrane repolarization during ventricular cardiac muscle cell action potential cardiac muscle cell action potential actin-mediated cell contraction potassium ion homeostasis inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis monoatomic cation homeostasis sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus hemopoiesis erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to xenobiotic stimulus response to xenobiotic stimulus positive regulation of cardiac muscle contraction positive regulation of striated muscle contraction regulation of cardiac muscle contraction regulation of muscle system process regulation of striated muscle contraction regulation of muscle contraction positive regulation of muscle contraction cardiac conduction regulation of heart rate by cardiac conduction renal sodium ion transport renal sodium ion absorption sodium ion transport intracellular monoatomic anion homeostasis intracellular chloride ion homeostasis monoatomic anion homeostasis cellular homeostasis intracellular chemical homeostasis chloride ion homeostasis intracellular monoatomic ion homeostasis atrial cardiac muscle cell to AV node cell signaling cell-cell signaling involved in cardiac conduction atrial cardiac muscle cell to AV node cell communication cell communication involved in cardiac conduction atrial cardiac muscle cell action potential ear morphogenesis embryonic organ morphogenesis embryonic morphogenesis embryo development anatomical structure morphogenesis sensory organ morphogenesis inner ear morphogenesis animal organ morphogenesis embryonic organ development cellular response to nitrogen compound response to organic substance response to organonitrogen compound response to endogenous stimulus response to organophosphorus cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound response to purine-containing compound response to cAMP cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to organonitrogen compound cellular response to cAMP cellular response to organic substance response to organic cyclic compound membrane repolarization during atrial cardiac muscle cell action potential atrial cardiac muscle cell membrane repolarization export across plasma membrane potassium ion export across plasma membrane response to epinephrine cellular response to epinephrine stimulus organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component organization organelle organization cellular component assembly cilium assembly cellular component organization or biogenesis non-motile cilium assembly cilium organization cell projection assembly regulation of delayed rectifier potassium channel activity negative regulation of delayed rectifier potassium channel activity detection of external stimulus detection of mechanical stimulus involved in sensory perception of sound response to mechanical stimulus response to external stimulus detection of mechanical stimulus involved in sensory perception detection of abiotic stimulus detection of stimulus detection of mechanical stimulus response to abiotic stimulus detection of stimulus involved in sensory perception regulation of atrial cardiac muscle cell membrane repolarization adrenergic receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction response to hormone response to peptide hormone response to insulin biological process involved in intraspecies interaction between organisms social behavior import into cell import across plasma membrane inorganic cation import across plasma membrane inorganic ion import across plasma membrane potassium ion import across plasma membrane regulation of gastric acid secretion regulation of digestive system process regulation of secretion positive regulation of cation transmembrane transport positive regulation of monoatomic ion transport positive regulation of transmembrane transport positive regulation of monoatomic ion transmembrane transport positive regulation of cellular process positive regulation of potassium ion transport positive regulation of transport positive regulation of potassium ion transmembrane transport digestive system development tube development digestive tract development stomach development	lumenal side of membrane membrane-bounded organelle organelle membrane cellular anatomical entity organelle membrane side of membrane basal part of cell basolateral part of cell lateral part of cell cell periphery plasma membrane basal plasma membrane plasma membrane region lumenal side of membrane membrane-bounded organelle organelle membrane cellular anatomical entity organelle membrane side of membrane basal part of cell basolateral part of cell lateral part of cell cell periphery plasma membrane basal plasma membrane plasma membrane region basolateral plasma membrane intracellular anatomical structure cytoplasm cell projection neuron projection plasma membrane bounded cell projection somatodendritic compartment cell body neuronal cell body protein-containing complex transmembrane transporter complex membrane protein complex transporter complex monoatomic ion channel complex apical part of cell apical plasma membrane membrane microdomain membrane raft transport vesicle intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle vesicle lytic vacuole vacuole lysosome voltage-gated potassium channel complex plasma membrane protein complex potassium channel complex cation channel complex cytoplasmic vesicle membrane vesicle membrane early endosome endosome late endosome ciliary base cilium endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013821	Potassium channel, voltage dependent, KCNQ, C-terminal	Domain
A, B	IPR005827	Potassium channel, voltage dependent, KCNQ1	Family
A, B	IPR003937	Potassium channel, voltage dependent, KCNQ	Family
A, B	IPR005821	Ion transport domain	Domain
A, B	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P51787	long QT syndrome Jervell and Lange-Nielsen syndrome short QT syndrome type 2 atrial fibrillation, familial, 3 familial atrial fibrillation type 2 diabetes mellitus granular cell carcinoma intestinal cancer tubular adenocarcinoma Jervell and Lange-Nielsen syndrome 1 long QT syndrome 1 Beckwith-Wiedemann syndrome short QT syndrome Sudden infant death syndrome adenocarcinoma long QT syndrome Jervell and Lange-Nielsen syndrome short QT syndrome type 2 atrial fibrillation, familial, 3 familial atrial fibrillation type 2 diabetes mellitus granular cell carcinoma intestinal cancer tubular adenocarcinoma Jervell and Lange-Nielsen syndrome 1 long QT syndrome 1 Beckwith-Wiedemann syndrome short QT syndrome Sudden infant death syndrome adenocarcinoma short QT syndrome type 1 gastric carcinoma multiple sclerosis atrial fibrillation pancreatic ductal adenocarcinoma autosomal dominant cardiac arrhythmia (Kuhn) diabetes mellitus gestational diabetes heart disease intestinal neoplasm acquired metabolic disease lung adenocarcinoma noise induced hearing loss atrial fibrillation, familial, 1 cribriform carcinoma familial long QT syndrome gout hypertrophic cardiomyopathy Lambert-Eaton myasthenic syndrome maturity-onset diabetes of the young adrenal cortex carcinoma cardiomyopathy cribriform carcinoma of breast tuberculosis esophageal adenocarcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.