3BF0

Crystal structure of Escherichia coli Signal peptide peptidase (SppA), Native crystals

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ClpP/crotonase	8053627	3000033	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ClpP/crotonase	8053626	3000033	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ClpP/crotonase	8053626	3000033	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ClpP/crotonase	8053627	3000033	SCOP2B (2022-06-29)
C	SCOP2 Family	SppA-like	8048911	4006261	SCOP2 (2022-06-29)
C	SCOP2 Family	SppA-like	8053629	4006261	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	ClpP/crotonase	8053626	3000033	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	ClpP/crotonase	8053627	3000033	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	ClpP/crotonase	8053626	3000033	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ClpP/crotonase	8053627	3000033	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Peptidase_S49	e3bf0A5	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S49	ECOD (1.6)
B	Peptidase_S49	e3bf0B5	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S49	ECOD (1.6)
C	Peptidase_S49	e3bf0C5	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S49	ECOD (1.6)
D	Peptidase_S49	e3bf0D5	A: a/b three-layered sandwiches	X: ClpP/crotonase (From Topology)	H: ClpP/crotonase (From Topology)	T: ClpP/crotonase	F: Peptidase_S49	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
A	3.40.1750.10	Alpha Beta	3-Layer(aba) Sandwich	peptide peptidase (sppa) fold	peptide peptidase (sppa) like domain	CATH (4.3.0)
B	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
B	3.40.1750.10	Alpha Beta	3-Layer(aba) Sandwich	peptide peptidase (sppa) fold	peptide peptidase (sppa) like domain	CATH (4.3.0)
C	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
C	3.40.1750.10	Alpha Beta	3-Layer(aba) Sandwich	peptide peptidase (sppa) fold	peptide peptidase (sppa) like domain	CATH (4.3.0)
D	3.90.226.10	Alpha Beta	Alpha-Beta Complex	2-enoyl-CoA Hydratase	Chain A, domain 1	CATH (4.3.0)
D	3.40.1750.10	Alpha Beta	3-Layer(aba) Sandwich	peptide peptidase (sppa) fold	peptide peptidase (sppa) like domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01343	Peptidase family S49 (Peptidase_S49)	Peptidase family S49	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Protease 4	peptidase activity serine hydrolase activity catalytic activity, acting on a protein serine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process signal peptide processing primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process biosynthetic process proteolysis organic substance biosynthetic process protein processing metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process signal peptide processing primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process biosynthetic process proteolysis organic substance biosynthetic process protein processing metabolic process cellular process protein metabolic process macromolecule metabolic process peptide metabolic process	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR029045	ClpP/crotonase-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR004634	Peptidase S49, protease IV	Family
A, B, C, D	IPR002142	Peptidase S49	Domain
A, B, C, D	IPR047217	Signal peptide peptidase A, N-terminal	Domain
A, B, C, D	IPR033854	Signal peptide peptidase A	Domain
A, B, C, D	IPR004635	Peptidase S49, SppA	Domain

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D	mpstruc	MONOTOPIC MEMBRANE PROTEINS	Peptidases	Signal Peptide Peptidase (SppA), native protein

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.