Annotations: 3AXJ

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3axja1	All alpha proteins	alpha-alpha superhelix	Translin	automated matches	automated matches	Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
A	d3axja2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Translin	8085081	4001994	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Translin	8085082	3000658	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01997	e3axjA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Translin (From Topology)	T: Translin	F: PF01997	ECOD (1.6)
B	PF01997	e3axjB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Translin (From Topology)	T: Translin	F: PF01997	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.190	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A	1.20.58.200	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	1.20.58.190	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	1.20.58.200	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01997	Translin family (Translin)	Translin family	-	Family
B	PF01997	Translin family (Translin)	Translin family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	GM27569p	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity RNA binding organic cyclic compound binding nucleic acid binding sequence-specific DNA binding DNA binding cation binding ion binding metal ion binding small molecule binding identical protein binding protein binding binding protein homodimerization activity protein dimerization activity RNA binding organic cyclic compound binding nucleic acid binding sequence-specific DNA binding DNA binding cation binding ion binding metal ion binding small molecule binding single-stranded DNA binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process post-transcriptional regulation of gene expression organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of protein stability biological regulation regulation of biological quality protein stabilization regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process post-transcriptional regulation of gene expression organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulatory ncRNA-mediated post-transcriptional gene silencing negative regulation of cellular biosynthetic process regulatory ncRNA-mediated gene silencing regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process post-transcriptional gene silencing regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process RNA metabolic process primary metabolic process nucleic acid metabolic process response to nutrient levels behavioral response to starvation response to stimulus response to stress response to starvation negative regulation of behavior rhythmic process circadian sleep/wake cycle, sleep multicellular organismal process circadian sleep/wake cycle rhythmic behavior negative regulation of circadian sleep/wake cycle, sleep regulation of circadian sleep/wake cycle circadian rhythm negative regulation of circadian rhythm regulation of circadian rhythm regulation of behavior behavior circadian behavior regulation of multicellular organismal process sleep negative regulation of multicellular organismal process regulation of circadian sleep/wake cycle, sleep circadian sleep/wake cycle process	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
B	Translin associated factor X, isoform B	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding sequence-specific DNA binding endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding sequence-specific DNA binding DNA binding cation binding ion binding metal ion binding small molecule binding	-	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016069	Translin, C-terminal	Homologous Superfamily
A	IPR036081	Translin superfamily	Homologous Superfamily
A	IPR016068	Translin, N-terminal	Homologous Superfamily
A	IPR002848	Translin family	Family
A	IPR033956	Translin	Family
B	IPR002848	Translin family	Family
B	IPR016069	Translin, C-terminal	Homologous Superfamily
B	IPR036081	Translin superfamily	Homologous Superfamily
B	IPR016068	Translin, N-terminal	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.