3AX2

Crystal structure of rat TOM20-ALDH presequence complex: a disulfide-tethered complex with a non-optimized, long linker

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02064	e3ax2A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: C-terminal domain of Ku80 (From Topology)	T: C-terminal domain of Ku80	F: PF02064	ECOD (1.6)
C	PF02064	e3ax2C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: C-terminal domain of Ku80 (From Topology)	T: C-terminal domain of Ku80	F: PF02064	ECOD (1.6)
E	PF02064	e3ax2E1	A: alpha superhelices	X: Repetitive alpha hairpins	H: C-terminal domain of Ku80 (From Topology)	T: C-terminal domain of Ku80	F: PF02064	ECOD (1.6)
G	PF02064	e3ax2G1	A: alpha superhelices	X: Repetitive alpha hairpins	H: C-terminal domain of Ku80 (From Topology)	T: C-terminal domain of Ku80	F: PF02064	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.960.10	Mainly Alpha	Up-down Bundle	Mitochondrial Import Receptor Subunit Tom20	Chain A	CATH (4.3.0)
C	1.20.960.10	Mainly Alpha	Up-down Bundle	Mitochondrial Import Receptor Subunit Tom20	Chain A	CATH (4.3.0)
E	1.20.960.10	Mainly Alpha	Up-down Bundle	Mitochondrial Import Receptor Subunit Tom20	Chain A	CATH (4.3.0)
G	1.20.960.10	Mainly Alpha	Up-down Bundle	Mitochondrial Import Receptor Subunit Tom20	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G	PF02064	MAS20 protein import receptor (MAS20)	MAS20 protein import receptor	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	Mitochondrial import receptor subunit TOM20 homolog	signal sequence binding binding peptide binding mitochondrion targeting sequence binding unfolded protein binding protein binding macromolecule transmembrane transporter activity active transmembrane transporter activity protein transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity protein transmembrane transporter activity protein-transporting ATPase activity transporter activity signal sequence binding binding peptide binding mitochondrion targeting sequence binding unfolded protein binding protein binding macromolecule transmembrane transporter activity active transmembrane transporter activity protein transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity protein transmembrane transporter activity protein-transporting ATPase activity transporter activity transmembrane transporter activity ATP-dependent activity	response to stimulus response to activity response to muscle activity protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell response to stimulus response to activity response to muscle activity protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process intracellular protein transport protein targeting establishment of protein localization to organelle protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion establishment of protein localization to mitochondrion response to 3,3',5-triiodo-L-thyronine response to acid chemical response to organic substance response to chemical response to organonitrogen compound response to oxygen-containing compound response to nitrogen compound response to amino acid response to organic cyclic compound protein transmembrane import into intracellular organelle protein import into mitochondrial matrix protein transmembrane transport mitochondrial transport mitochondrial transmembrane transport transmembrane transport import into the mitochondrion RNA transport nucleic acid transport tRNA transport establishment of RNA localization RNA import into mitochondrion tRNA import into mitochondrion RNA localization nucleobase-containing compound transport	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle organelle envelope mitochondrial envelope mitochondrial protein-containing complex protein-containing complex mitochondrial membrane outer mitochondrial membrane protein complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle organelle envelope mitochondrial envelope mitochondrial protein-containing complex protein-containing complex mitochondrial membrane outer mitochondrial membrane protein complex membrane membrane protein complex organelle outer membrane bounding membrane of organelle mitochondrial outer membrane mitochondrial outer membrane translocase complex outer membrane organelle membrane organelle membrane contact site mitochondria-associated endoplasmic reticulum membrane contact site cell periphery cell projection sperm midpiece cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection migrasome
B, D, F, H	Aldehyde dehydrogenase, mitochondrial	hydrolase activity, acting on ester bonds carboxylesterase activity carboxylic ester hydrolase activity hydrolase activity catalytic activity nitroglycerin reductase activity oxidoreductase activity oxidoreductase activity, acting on other nitrogenous compounds as donors oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor oxidoreductase activity, acting on the aldehyde or oxo group of donors glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor NAD binding NADH binding hydrolase activity, acting on ester bonds carboxylesterase activity carboxylic ester hydrolase activity hydrolase activity catalytic activity nitroglycerin reductase activity oxidoreductase activity oxidoreductase activity, acting on other nitrogenous compounds as donors oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor oxidoreductase activity, acting on the aldehyde or oxo group of donors glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor NAD binding NADH binding binding nucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding small molecule binding aldehyde dehydrogenase (NAD+) activity phenylacetaldehyde dehydrogenase activity aldehyde dehydrogenase [NAD(P)+] activity identical protein binding protein binding	developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development response to oxidative stress regulation of biological process response to stimulus regulation of response to stimulus response to stress developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development response to oxidative stress regulation of biological process response to stimulus regulation of response to stimulus response to stress regulation of response to stress regulation of response to oxidative stress biological regulation cellular component organization organelle organization apoptotic mitochondrial changes cellular process apoptotic process cellular component organization or biogenesis cell death programmed cell death mitochondrion organization response to organic substance response to ketone response to lipid response to endogenous stimulus response to progesterone response to oxygen-containing compound response to hormone response to steroid hormone response to chemical response to organic cyclic compound cellular response to stimulus cellular response to organic cyclic compound response to stilbenoid cellular response to oxygen-containing compound cellular response to resveratrol cellular response to chemical stimulus cellular response to organic substance response to resveratrol regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death negative regulation of apoptotic process negative regulation of cellular process response to ischemia response to testosterone cellular response to endogenous stimulus cellular response to hormone stimulus cellular catabolic process organic substance metabolic process catabolic process cellular aldehyde metabolic process cellular metabolic process metabolic process aldehyde catabolic process organic substance catabolic process organic hydroxy compound metabolic process alcohol metabolic process small molecule metabolic process ethanol metabolic process primary alcohol metabolic process alcohol catabolic process primary alcohol catabolic process organic hydroxy compound catabolic process ethanol catabolic process small molecule catabolic process behavior adult behavior response to alcohol behavioral response to ethanol response to ethanol cellular detoxification detoxification response to toxic substance cellular detoxification of aldehyde cellular response to aldehyde cellular response to toxic substance organonitrogen compound biosynthetic process dopamine metabolic process catechol-containing compound metabolic process regulation of primary metabolic process biogenic amine biosynthetic process catecholamine metabolic process dopamine biosynthetic process catecholamine biosynthetic process organic substance biosynthetic process catechol-containing compound biosynthetic process regulation of dopamine metabolic process regulation of biosynthetic process organonitrogen compound metabolic process regulation of amine metabolic process primary metabolic process regulation of dopamine biosynthetic process organic cyclic compound metabolic process amine metabolic process biosynthetic process amine biosynthetic process phenol-containing compound metabolic process organic hydroxy compound biosynthetic process organic cyclic compound biosynthetic process phenol-containing compound biosynthetic process regulation of catecholamine metabolic process regulation of metabolic process biogenic amine metabolic process response to fatty acid cellular response to fatty acid cellular response to lipid reactive oxygen species metabolic process regulation of cellular metabolic process regulation of reactive oxygen species metabolic process response to nicotine acetaldehyde metabolic process intrinsic apoptotic signaling pathway in response to oxidative stress signaling intracellular signal transduction cell communication apoptotic signaling pathway signal transduction intrinsic apoptotic signaling pathway biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin serotonin metabolic process indole-containing compound metabolic process primary amino compound metabolic process ammonium ion metabolic process indole-containing compound biosynthetic process serotonin biosynthetic process primary amino compound biosynthetic process regulation of serotonin biosynthetic process response to estradiol response to oxygen levels response to abiotic stimulus response to hyperoxia response to increased oxygen levels	membrane-bounded organelle intracellular anatomical structure mitochondrion membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle mitochondrial matrix intracellular organelle lumen intracellular organelle organelle lumen organelle cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR023392	Mitochondrial outer membrane translocase complex, Tom20 domain superfamily	Homologous Superfamily
A, C, E, G	IPR022422	Protein import receptor MAS20, metazoan	Family
A, C, E, G	IPR002056	Protein import receptor MAS20	Family
B, D, F, H	IPR015590	Aldehyde dehydrogenase domain	Domain
B, D, F, H	IPR016161	Aldehyde/histidinol dehydrogenase	Homologous Superfamily
B, D, F, H	IPR029510	Aldehyde dehydrogenase, glutamic acid active site	Conserved Site
B, D, F, H	IPR016160	Aldehyde dehydrogenase, cysteine active site	Conserved Site
B, D, F, H	IPR016162	Aldehyde dehydrogenase, N-terminal	Homologous Superfamily
B, D, F, H	IPR016163	Aldehyde dehydrogenase, C-terminal	Homologous Superfamily

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B, D, F, H	NH2	RESID: AA0081 , AA0083 , AA0084 , AA0086 , AA0087 , AA0088 , AA0090 , AA0091 , AA0092 , AA0093 , AA0095 , AA0096 , AA0097 , AA0098 , AA0099 , AA0100 PSI-MOD : L-alanine amide MOD:00090 , L-asparagine amide MOD:00092 , L-aspartic acid 1-amide MOD:00093 , L-glutamine amide MOD:00095 , L-glutamic acid 1-amide MOD:00096 , glycine amide MOD:00097 , L-isoleucine amide MOD:00099 , L-leucine amide MOD:00100 , L-lysine amide MOD:00101 , L-methionine amide MOD:00102 , L-proline amide MOD:00104 , L-serine amide MOD:00105 , L-threonine amide MOD:00106 , L-tryptophan amide MOD:00107 , L-tyrosine amide MOD:00108 , L-valine amide MOD:00109

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.