3AQP

Crystal structure of SecDF, a translocon-associated membrane protein, from Thermus thrmophilus

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	secD	e3aqpB5	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: secD	ECOD (1.6)
B	SecD_SecF	e3aqpB1	A: alpha bundles	X: Multidrug efflux transporter AcrB transmembrane domain (From Topology)	H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)	T: Multidrug efflux transporter AcrB transmembrane domain	F: SecD_SecF	ECOD (1.6)
B	secD_1	e3aqpB4	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: secD_1	ECOD (1.6)
B	3a0501s07	e3aqpB2	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: 3a0501s07	ECOD (1.6)
A	secD	e3aqpA3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel	F: secD	ECOD (1.6)
A	SecD_SecF	e3aqpA1	A: alpha bundles	X: Multidrug efflux transporter AcrB transmembrane domain (From Topology)	H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)	T: Multidrug efflux transporter AcrB transmembrane domain	F: SecD_SecF	ECOD (1.6)
A	secD_1	e3aqpA2	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: secD_1	ECOD (1.6)
A	3a0501s07	e3aqpA5	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin domains in multidrug efflux transporter	T: Multidrug efflux transporter AcrB pore domain	F: 3a0501s07	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.70.3220	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
B	3.30.1360.200	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
A	3.30.70.3220	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
A	3.30.1360.200	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21760	Protein translocase subunit SecDF, P1 domain, N-terminal (SecD_1st)	Protein translocase subunit SecDF, P1 domain, N-terminal	This domain is found in Protein translocase subunit SecDF from Thermus thermophilus, which belongs to the RND superfamily. SecDF shows 12 transmembrane (TM) regions and 6 periplasmic regions (P1-P6). This entry represents the N-terminal region of the ...	This domain is found in Protein translocase subunit SecDF from Thermus thermophilus, which belongs to the RND superfamily. SecDF shows 12 transmembrane (TM) regions and 6 periplasmic regions (P1-P6). This entry represents the N-terminal region of the base subdomain of the P1 domain that is located in the N- terminal half of the polypeptide, also known as SecD region. This domain folds into a a pseudo-symmetrical anti-parallel beta-sheet that rearranges to a beta-barrel architecture during ion transport. This domain, which covers the TM region [1-4], is related to Pfam:PF03176 and usually appears associated with Pfam:PF07549 and Pfam:PF02355.	Domain
A, B	PF02355	Protein export membrane protein (SecD_SecF)	Protein export membrane protein	-	Family
A, B	PF07549	SecD/SecF GG Motif (Sec_GG)	SecD/SecF GG Motif	-	Motif

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Probable SecDF protein-export membrane protein	macromolecule transmembrane transporter activity active transmembrane transporter activity protein transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity protein transmembrane transporter activity protein-transporting ATPase activity transporter activity transmembrane transporter activity ATP-dependent activity	protein localization localization establishment of protein localization cellular localization protein targeting cellular macromolecule localization macromolecule localization cellular process establishment of localization nitrogen compound transport transport intracellular protein transmembrane transport organic substance transport intracellular transport protein localization localization establishment of protein localization cellular localization protein targeting cellular macromolecule localization macromolecule localization cellular process establishment of localization nitrogen compound transport transport intracellular protein transmembrane transport organic substance transport intracellular transport transmembrane transport protein transmembrane transport protein transport establishment of localization in cell intracellular protein transport protein transport by the Sec complex	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR005665	Protein-export membrane protein SecF, bacterial	Family
A, B	IPR022646	Protein-export membrane protein SecD/SecF/SecDF, conserved site	Conserved Site
A, B	IPR000731	Sterol-sensing domain	Domain
A, B	IPR022645	Protein-export membrane protein SecD/SecF, bacterial	Family
A, B	IPR048631	Protein translocase subunit SecDF, P1 domain, N-terminal	Domain
A, B	IPR022813	Protein-export membrane protein SecD/SecF, archaeal and bacterial	Family
A, B	IPR048634	Protein export membrane protein SecD/SecF, C-terminal	Domain
A, B	IPR005791	Protein translocase subunit SecD	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	Resistance-nodulation-cell division	SecDF protein-export membrane protein

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Sec, Translocase, and Insertase Proteins	SecDF protein-export enhancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.