Annotations: 3AQF

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	RAMP1-like	8054001	3002261	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	FnI-like domain	8091130	3000979	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RAMP	e3aqfA1	A: alpha bundles	X: Receptor activity-modifying protein (RAMP) (From Topology)	H: Receptor activity-modifying protein (RAMP) (From Topology)	T: Receptor activity-modifying protein (RAMP)	F: RAMP	ECOD (1.6)
B	HRM	e3aqfB1	A: few secondary structure elements	X: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	H: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	T: Hormone receptor domain (HRM, Pfam 02793)	F: HRM	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.150.510	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
B	4.10.1240.10	Few Secondary Structures	Irregular	Hormone receptor fold	GPCR, family 2, extracellular hormone receptor domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF04901	Receptor activity modifying family (RAMP)	Receptor activity modifying family	-	Family
B	PF02793	Hormone receptor domain (HRM)	Hormone receptor domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Receptor activity-modifying protein 2	molecular transducer activity coreceptor activity signaling receptor activity calcitonin family binding amide binding binding adrenomedullin binding peptide hormone binding hormone binding calcitonin family receptor activity peptide receptor activity adrenomedullin receptor activity G protein-coupled receptor activity G protein-coupled peptide receptor activity molecular transducer activity coreceptor activity signaling receptor activity calcitonin family binding amide binding binding adrenomedullin binding peptide hormone binding hormone binding calcitonin family receptor activity peptide receptor activity adrenomedullin receptor activity G protein-coupled receptor activity G protein-coupled peptide receptor activity transmembrane signaling receptor activity	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development system process circulatory system process regulation of blood pressure biological regulation regulation of biological quality blood circulation developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development system process circulatory system process regulation of blood pressure biological regulation regulation of biological quality blood circulation localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport blood vessel morphogenesis tube development angiogenesis vasculature development anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process regulation of developmental process cellular developmental process regulation of vasculogenesis regulation of cell differentiation vasculogenesis positive regulation of developmental process positive regulation of cell differentiation cell differentiation positive regulation of vasculogenesis protein localization establishment of protein localization cellular localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization smooth muscle cell differentiation cell development muscle cell differentiation muscle structure development vascular associated smooth muscle cell differentiation muscle cell development vascular associated smooth muscle cell development protein localization to cell periphery protein localization to plasma membrane localization within membrane protein localization to membrane cellular response to stimulus response to organic substance response to stimulus response to endogenous stimulus cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical cellular response to organic substance cellular response to hormone stimulus sprouting angiogenesis negative regulation of vascular permeability regulation of vascular permeability vascular process in circulatory system signaling adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction bicellular tight junction assembly tight junction organization apical junction assembly cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly tight junction assembly cellular component organization or biogenesis cell-cell junction assembly cell-cell junction organization intracellular transport establishment of localization in cell intracellular protein transport regulation of signaling regulation of signal transduction regulation of response to stimulus regulation of cell communication regulation of G protein-coupled receptor signaling pathway adrenomedullin receptor signaling pathway calcitonin family receptor signaling pathway regulation of vasculature development regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis positive regulation of multicellular organismal process extracellular matrix organization basement membrane assembly extracellular matrix assembly basement membrane organization extracellular structure organization external encapsulating structure organization monoatomic ion transport monoatomic cation transport calcium ion transport metal ion transport negative regulation of endothelial cell apoptotic process regulation of epithelial cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death epithelial cell apoptotic process negative regulation of apoptotic process negative regulation of epithelial cell apoptotic process negative regulation of cellular process endothelial cell apoptotic process apoptotic process programmed cell death regulation of endothelial cell apoptotic process adherens junction organization adherens junction assembly cellular response to growth factor stimulus cellular response to vascular endothelial growth factor stimulus response to growth factor	clathrin-coated pit membrane cellular anatomical entity endomembrane system cell surface cell periphery plasma membrane intracellular anatomical structure cytoplasm protein-containing complex plasma membrane protein complex membrane protein complex receptor complex G protein-coupled receptor dimeric complex clathrin-coated pit membrane cellular anatomical entity endomembrane system cell surface cell periphery plasma membrane intracellular anatomical structure cytoplasm protein-containing complex plasma membrane protein complex membrane protein complex receptor complex G protein-coupled receptor dimeric complex adrenomedullin receptor complex plasma membrane signaling receptor complex G protein-coupled receptor complex calcitonin family receptor complex membrane-bounded organelle intracellular organelle organelle lytic vacuole vacuole intracellular membrane-bounded organelle lysosome
B	Calcitonin gene-related peptide type 1 receptor	calcitonin family receptor activity peptide receptor activity molecular transducer activity G protein-coupled receptor activity G protein-coupled peptide receptor activity transmembrane signaling receptor activity signaling receptor activity calcitonin receptor activity calcitonin family binding amide binding binding adrenomedullin binding peptide hormone binding hormone binding calcitonin family receptor activity peptide receptor activity molecular transducer activity G protein-coupled receptor activity G protein-coupled peptide receptor activity transmembrane signaling receptor activity signaling receptor activity calcitonin receptor activity calcitonin family binding amide binding binding adrenomedullin binding peptide hormone binding hormone binding adrenomedullin receptor activity calcitonin gene-related peptide receptor activity	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport blood vessel morphogenesis tube development angiogenesis vasculature development anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development protein localization establishment of protein localization cellular localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization regulation of vascular associated smooth muscle cell proliferation regulation of biological process cell population proliferation regulation of cellular process positive regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation biological regulation positive regulation of biological process smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation vascular associated smooth muscle cell proliferation positive regulation of cellular process cellular response to stimulus response to stimulus signaling adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction cell surface receptor signaling pathway adrenomedullin receptor signaling pathway calcitonin family receptor signaling pathway calcitonin gene-related peptide receptor signaling pathway response to organic substance response to disaccharide response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to sucrose stimulus cellular response to carbohydrate stimulus cellular response to chemical stimulus response to carbohydrate response to sucrose response to chemical cellular response to disaccharide stimulus cellular response to organic substance monoatomic ion transport monoatomic cation transport calcium ion transport metal ion transport G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	cell periphery plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm protein-containing complex plasma membrane protein complex membrane protein complex receptor complex G protein-coupled receptor dimeric complex adrenomedullin receptor complex plasma membrane signaling receptor complex G protein-coupled receptor complex cell periphery plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm protein-containing complex plasma membrane protein complex membrane protein complex receptor complex G protein-coupled receptor dimeric complex adrenomedullin receptor complex plasma membrane signaling receptor complex G protein-coupled receptor complex calcitonin family receptor complex membrane-bounded organelle intracellular organelle organelle lytic vacuole vacuole intracellular membrane-bounded organelle lysosome endosome intracellular vesicle endomembrane system cytoplasmic vesicle vesicle CGRP receptor complex endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR006985	Receptor activity modifying protein	Family
A	IPR038126	RAMP domain superfamily	Homologous Superfamily
B	IPR017983	GPCR, family 2, secretin-like, conserved site	Conserved Site
B	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily	Homologous Superfamily
B	IPR000832	GPCR, family 2, secretin-like	Family
B	IPR017981	GPCR, family 2-like, 7TM	Domain
B	IPR001879	GPCR, family 2, extracellular hormone receptor domain	Domain
B	IPR003287	GPCR, family 2, calcitonin receptor family	Family
B	IPR003289	GPCR, family 2, calcitonin gene-related peptide, type 1 receptor	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O60895	adenocarcinoma adult acute respiratory distress syndrome tubular adenocarcinoma Weight Gain granular cell carcinoma psoriasis glioblastoma large cell medulloblastoma lung cancer non-small cell lung carcinoma cribriform carcinoma lung adenocarcinoma lung carcinoma medulloblastoma primitive neuroectodermal tumor adenocarcinoma adult acute respiratory distress syndrome tubular adenocarcinoma Weight Gain granular cell carcinoma psoriasis glioblastoma large cell medulloblastoma lung cancer non-small cell lung carcinoma cribriform carcinoma lung adenocarcinoma lung carcinoma medulloblastoma primitive neuroectodermal tumor cribriform carcinoma of breast invasive ductal breast carcinoma lung benign neoplasm nephrosclerosis
B	Pharos: Q16602	allergic contact dermatitis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Preventive treatment of episodic migraine in adults tuberculosis glioblastoma large cell medulloblastoma lung carcinoma medulloblastoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma primitive neuroectodermal tumor ulcerative colitis astrocytic tumor heart disease allergic contact dermatitis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Preventive treatment of episodic migraine in adults tuberculosis glioblastoma large cell medulloblastoma lung carcinoma medulloblastoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma primitive neuroectodermal tumor ulcerative colitis astrocytic tumor heart disease lung adenocarcinoma malignant ependymoma migraine disorder osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis atypical teratoid rhabdoid tumor interstitial cystitis lung cancer malignant glioma non-small cell lung carcinoma ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.