3AQC

M. luteus B-P 26 heterodimeric hexaprenyl diphosphate synthase in complex with magnesium and FPP analogue

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Terpenoid synthases	8098200	3001615	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Terpenoid synthases	8098200	3001615	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF22538	e3aqcA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Group V grass pollen allergen (From Topology)	T: Group V grass pollen allergen	F: PF22538	ECOD (1.6)
C	PF22538	e3aqcC1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Group V grass pollen allergen (From Topology)	T: Group V grass pollen allergen	F: PF22538	ECOD (1.6)
B	PF00348	e3aqcB1	A: alpha bundles	X: Terpenoid synthases (From Topology)	H: Terpenoid synthases (From Topology)	T: Terpenoid synthases	F: PF00348	ECOD (1.6)
D	PF00348	e3aqcD1	A: alpha bundles	X: Terpenoid synthases (From Topology)	H: Terpenoid synthases (From Topology)	T: Terpenoid synthases	F: PF00348	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.120.1450	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)		CATH (4.3.0)
C	1.20.120.1450	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)		CATH (4.3.0)
B	1.10.600.10	Mainly Alpha	Orthogonal Bundle	Farnesyl Diphosphate Synthase	Farnesyl Diphosphate Synthase	CATH (4.3.0)
D	1.10.600.10	Mainly Alpha	Orthogonal Bundle	Farnesyl Diphosphate Synthase	Farnesyl Diphosphate Synthase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D	PF00348	Polyprenyl synthetase (polyprenyl_synt)	Polyprenyl synthetase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Component A of hexaprenyl diphosphate synthase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups catalytic activity hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity prenyltransferase activity	small molecule biosynthetic process cellular biosynthetic process cellular metabolic process cellular ketone metabolic process organic substance metabolic process biosynthetic process menaquinone metabolic process organic substance biosynthetic process small molecule metabolic process metabolic process cellular process menaquinone biosynthetic process ketone biosynthetic process	-
B, D	Component B of hexaprenyl diphosphate synthase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups catalytic activity hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity prenyltransferase activity	isoprenoid biosynthetic process cellular biosynthetic process cellular metabolic process lipid biosynthetic process primary metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cellular lipid metabolic process metabolic process cellular process lipid metabolic process isoprenoid metabolic process small molecule biosynthetic process isoprenoid biosynthetic process cellular biosynthetic process cellular metabolic process lipid biosynthetic process primary metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cellular lipid metabolic process metabolic process cellular process lipid metabolic process isoprenoid metabolic process small molecule biosynthetic process cellular ketone metabolic process menaquinone metabolic process small molecule metabolic process menaquinone biosynthetic process ketone biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, D	IPR000092	Polyprenyl synthetase	Family
B, D	IPR008949	Isoprenoid synthase domain superfamily	Homologous Superfamily
B, D	IPR033749	Polyprenyl synthetase, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.