Annotations: 3AFC

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Sema domain-like	8098144	3000180	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Plexin repeat-like	8101120	3000415	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Sema domain-like	8098144	3000180	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01403	e3afcA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF01403	ECOD (1.6)
A	PF01437	e3afcA2	A: few secondary structure elements	X: Trefoil/Plexin domain-like (From Topology)	H: Trefoil/Plexin domain-like (From Topology)	T: Trefoil/Plexin domain-like	F: PF01437	ECOD (1.6)
B	PF01403	e3afcB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF01403	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
A	3.30.1680.10	Alpha Beta	2-Layer Sandwich	ligand-binding face of the semaphorins, domain 2	ligand-binding face of the semaphorins, domain 2	CATH (4.3.0)
B	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01437	Plexin repeat (PSI)	Plexin repeat	-	Family
A, B	PF01403	Sema domain (Sema)	Sema domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Semaphorin-6A	protein binding binding semaphorin receptor binding signaling receptor binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity chemorepellent activity receptor ligand activity signaling receptor activator activity identical protein binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	localization centrosome localization microtubule organizing center localization cellular process multicellular organismal process regulation of sprouting angiogenesis regulation of developmental process negative regulation of biological process angiogenesis regulation of vasculature development multicellular organism development tube morphogenesis anatomical structure development regulation of multicellular organismal process localization centrosome localization microtubule organizing center localization cellular process multicellular organismal process regulation of sprouting angiogenesis regulation of developmental process negative regulation of biological process angiogenesis regulation of vasculature development multicellular organism development tube morphogenesis anatomical structure development regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development developmental process regulation of multicellular organismal development regulation of biological process blood vessel morphogenesis tube development negative regulation of blood vessel morphogenesis negative regulation of developmental process biological regulation negative regulation of angiogenesis sprouting angiogenesis vasculature development circulatory system development anatomical structure morphogenesis negative regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis negative regulation of multicellular organismal process negative regulation of sprouting angiogenesis negative regulation of locomotion response to stimulus developmental growth cell projection organization negative regulation of chemotaxis neuron projection development regulation of cell development cell projection morphogenesis neuron differentiation cell differentiation regulation of biological quality chemotaxis regulation of cell projection organization response to external stimulus generation of neurons negative regulation of axonogenesis negative regulation of developmental growth regulation of response to stimulus regulation of neuron projection development regulation of cellular component organization regulation of response to external stimulus plasma membrane bounded cell projection morphogenesis cell development cell growth neurogenesis negative regulation of neurogenesis regulation of axon extension involved in axon guidance regulation of extent of cell growth negative regulation of nervous system development negative regulation of cell differentiation locomotion neuron projection extension regulation of developmental growth developmental cell growth growth axon development negative regulation of axon extension regulation of chemotaxis regulation of cell growth cell morphogenesis involved in neuron differentiation negative regulation of cell development neuron projection guidance neuron development axon extension regulation of growth regulation of cellular process axonogenesis regulation of cellular component size regulation of cell differentiation regulation of neurogenesis negative regulation of growth neuron projection morphogenesis taxis neuron projection extension involved in neuron projection guidance negative regulation of cellular component organization negative regulation of axon extension involved in axon guidance negative regulation of cell growth nervous system development developmental growth involved in morphogenesis response to chemical regulation of locomotion negative regulation of response to external stimulus cellular developmental process cell morphogenesis regulation of axon extension cellular component organization regulation of nervous system development regulation of axonogenesis negative regulation of cellular process cellular component organization or biogenesis axon extension involved in axon guidance negative regulation of cell projection organization regulation of cell size plasma membrane bounded cell projection organization negative regulation of response to stimulus axon guidance negative regulation of neuron projection development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size apoptotic process cell death programmed cell death positive regulation of locomotion regulation of cell motility positive regulation of biological process regulation of neuron migration positive regulation of cell migration positive regulation of cell motility regulation of cell migration cell migration cell motility positive regulation of cellular process neuron migration positive regulation of neuron migration cellular response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling regulation of MAPK cascade negative regulation of signal transduction negative regulation of ERK1 and ERK2 cascade MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade stem cell development neural crest cell differentiation animal organ development neural crest cell development mesenchyme development tissue development mesenchymal cell migration stem cell differentiation ameboidal-type cell migration mesenchymal cell differentiation neural crest cell migration cell adhesion involved in sprouting angiogenesis negative regulation of cell adhesion cell adhesion angiogenic sprout fusion regulation of cell adhesion regulation of cell adhesion involved in sprouting angiogenesis negative regulation of cell adhesion involved in sprouting angiogenesis cell surface receptor signaling pathway semaphorin-plexin signaling pathway negative chemotaxis cellular response to growth factor stimulus negative regulation of vascular endothelial growth factor signaling pathway negative regulation of cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus regulation of vascular endothelial growth factor signaling pathway enzyme-linked receptor protein signaling pathway regulation of cellular response to vascular endothelial growth factor stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus vascular endothelial growth factor signaling pathway cellular response to vascular endothelial growth factor stimulus response to growth factor negative regulation of cellular response to vascular endothelial growth factor stimulus	membrane cellular anatomical entity cell periphery plasma membrane axon cell projection neuron projection plasma membrane bounded cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR027231	Semaphorin	Family
A, B	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A, B	IPR002165	Plexin repeat	Repeat
A, B	IPR036352	Sema domain superfamily	Homologous Superfamily
A, B	IPR001627	Sema domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.