2LLE

Computational design of an eight-stranded (beta/alpha)-barrel from fragments of different folds

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00977	e2lleA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00977	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.70	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Aldolase class I	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00977	Histidine biosynthesis protein (His_biosynth)	Histidine biosynthesis protein	-	Family
A	PF00072	Response regulator receiver domain (Response_reg)	Response regulator receiver domain	This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Chemotaxis protein CheY, Imidazole glycerol phosphate synthase subunit HisF chimera	lyase activity catalytic activity imidazoleglycerol-phosphate synthase activity pentosyltransferase activity glycosyltransferase activity transferase activity cation binding ion binding binding metal ion binding small molecule binding	organonitrogen compound metabolic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process small molecule metabolic process organonitrogen compound metabolic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process small molecule metabolic process metabolic process cellular process histidine metabolic process histidine biosynthetic process chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion cell motility archaeal or bacterial-type flagellum-dependent cell motility cilium or flagellum-dependent cell motility cellular response to stimulus regulation of biological process phosphorelay signal transduction system regulation of cellular process signaling biological regulation intracellular signal transduction cell communication signal transduction	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011060	Ribulose-phosphate binding barrel	Homologous Superfamily
A	IPR004651	Histidine biosynthesis, HisF	Family
A	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A	IPR006062	Histidine biosynthesis protein	Family
A	IPR011006	CheY-like superfamily	Homologous Superfamily
A	IPR001789	Signal transduction response regulator, receiver domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.