Annotations: 2ZPA

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UNK_F_TYPE	e2zpaA3	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: UNK_F_TYPE	ECOD (1.6)
A	GNAT_acetyltr_2	e2zpaA1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: GNAT_acetyltr_2	ECOD (1.6)
A	DUF1726	e2zpaA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: DUF1726	ECOD (1.6)
A	Helicase_RecD	e2zpaA4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Helicase_RecD	ECOD (1.6)
B	UNK_F_TYPE	e2zpaB4	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: UNK_F_TYPE	ECOD (1.6)
B	GNAT_acetyltr_2	e2zpaB3	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: GNAT_acetyltr_2	ECOD (1.6)
B	DUF1726	e2zpaB6	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: DUF1726	ECOD (1.6)
B	Helicase_RecD	e2zpaB5	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Helicase_RecD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.11040	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
A	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
A	1.20.120.890	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	tRNA(Met) cytidine acetyltransferase, tail domain	CATH (4.3.0)
B	3.40.50.11040	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
B	1.20.120.890	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	tRNA(Met) cytidine acetyltransferase, tail domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF17176	tRNA-binding domain (tRNA_bind_3)	tRNA-binding domain	This domain, found at the C-terminus of tRNA(Met) cytidine acyltransferase, may be involved in tRNA-binding [1]. This family represents the tRNA-binding domain proteins not captured by Pfam:PF13725.	Domain
A, B	PF08351	tRNA(Met) cytidine acetyltransferase TmcA, N-terminal (TmcA_N)	tRNA(Met) cytidine acetyltransferase TmcA, N-terminal	-	Family
A, B	PF13718	GNAT acetyltransferase 2 (GNAT_acetyltr_2)	GNAT acetyltransferase 2	-	Family
A, B	PF05127	Helicase (Helicase_RecD)	Helicase	This domain contains a P-loop (Walker A) motif, suggesting that it has ATPase activity, and a Walker B motif. In tRNA(Met) cytidine acetyltransferase (TmcA) it may function as an RNA helicase motor (driven by ATP hydrolysis) which delivers the wobble ...	This domain contains a P-loop (Walker A) motif, suggesting that it has ATPase activity, and a Walker B motif. In tRNA(Met) cytidine acetyltransferase (TmcA) it may function as an RNA helicase motor (driven by ATP hydrolysis) which delivers the wobble base to the active centre of the GCN5-related N-acetyltransferase (GNAT) domain [1]. It is found in the bacterial exodeoxyribonuclease V alpha chain (RecD), which has 5'-3' helicase activity. It is structurally similar to the motor domain 1A in other SF1 helicases [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Uncharacterized protein ypfI	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity acetyltransferase activity N-acetyltransferase activity tRNA N-acetyltransferase activity N-acyltransferase activity peptide 2-hydroxyisobutyryltransferase activity RNA binding tRNA binding nucleic acid binding	cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing RNA acetylation cellular metabolic process tRNA modification primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process organic substance metabolic process tRNA processing organic substance biosynthetic process RNA processing RNA acetylation cellular metabolic process tRNA modification primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process organic cyclic compound metabolic process RNA modification biosynthetic process macromolecule modification ncRNA metabolic process nucleic acid catabolic process metabolic process cellular process tRNA acetylation macromolecule metabolic process tRNA wobble cytosine modification tRNA wobble base modification	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR032672	TmcA/NAT10/Kre33	Family
A, B	IPR024914	tRNA(Met) cytidine acetyltransferase TmcA	Family
A, B	IPR013562	tRNA(Met) cytidine acetyltransferase TmcA, N-terminal	Domain
A, B	IPR000182	GNAT domain	Domain
A, B	IPR033442	tRNA(Met) cytidine acetyltransferase TmcA, tRNA-binding domain	Domain
A, B	IPR038321	TmcA, C-terminal domain superfamily	Homologous Superfamily
A, B	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
A, B	IPR007807	Helicase domain	Domain
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.