2ZOU

Crystal structure of human F-spondin reeler domain (fragment 2)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02014	e2zouA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02014	ECOD (1.6)
B	PF02014	e2zouB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02014	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.4060	Mainly Beta	Sandwich	Immunoglobulin-like	Reeler domain	CATH (4.3.0)
B	2.60.40.4060	Mainly Beta	Sandwich	Immunoglobulin-like	Reeler domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02014	Reeler domain (Reeler)	Reeler domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Spondin-1	structural molecule activity extracellular matrix structural constituent protein binding binding LBD domain binding protein domain specific binding cation binding ion binding metal ion binding small molecule binding	amyloid precursor protein catabolic process regulation of biological process organonitrogen compound metabolic process positive regulation of protein metabolic process regulation of protein metabolic process biological regulation positive regulation of biological process primary metabolic process regulation of amyloid precursor protein catabolic process regulation of macromolecule metabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process metabolic process amyloid precursor protein catabolic process regulation of biological process organonitrogen compound metabolic process positive regulation of protein metabolic process regulation of protein metabolic process biological regulation positive regulation of biological process primary metabolic process regulation of amyloid precursor protein catabolic process regulation of macromolecule metabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process metabolic process positive regulation of macromolecule metabolic process protein metabolic process macromolecule metabolic process positive regulation of amyloid precursor protein catabolic process amyloid precursor protein metabolic process regulation of metabolic process regulation of amide metabolic process regulation of amyloid-beta formation negative regulation of biological process negative regulation of amyloid precursor protein catabolic process amyloid-beta metabolic process amide metabolic process negative regulation of protein metabolic process amyloid-beta formation negative regulation of macromolecule metabolic process negative regulation of amyloid-beta formation negative regulation of amide metabolic process negative regulation of metabolic process cell adhesion cellular process regulation of protein maturation positive regulation of protein maturation regulation of cellular process cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of protein processing protein maturation regulation of proteolysis positive regulation of biosynthetic process proteolysis organic substance biosynthetic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of proteolysis regulation of protein processing protein processing regulation of macromolecule biosynthetic process positive regulation of cellular biosynthetic process	membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm cell periphery membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm cell periphery extracellular matrix external encapsulating structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000884	Thrombospondin type-1 (TSP1) repeat	Repeat
A, B	IPR042307	Reeler domain superfamily	Homologous Superfamily
A, B	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily	Homologous Superfamily
A, B	IPR002861	Reeler domain	Domain
A, B	IPR009465	Spondin, N-terminal	Domain
A, B	IPR044004	Spondin-like TSP1 domain	Domain
A, B	IPR038678	Spondin, N-terminal domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9HCB6	tuberculosis pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia sinusitis ulcerative colitis adrenal cortex adenoma astrocytic tumor cystic fibrosis large cell medulloblastoma lung carcinoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer subependymal giant cell astrocytoma tuberculosis pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia sinusitis ulcerative colitis adrenal cortex adenoma astrocytic tumor cystic fibrosis large cell medulloblastoma lung carcinoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer subependymal giant cell astrocytoma adrenal cortex carcinoma atypical teratoid rhabdoid tumor glioblastoma lung adenocarcinoma malignant ependymoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis Alzheimer disease breast cancer invasive ductal breast carcinoma lung cancer malignant mesothelioma oligodendroglioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.