2Z80

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	LRR_8_1	e2z80A1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)
B	LRR_8_1	e2z80B1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat
A, B	PF00560	Leucine Rich Repeat (LRR_1)	Leucine Rich Repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Toll-like receptor 2, Variable lymphocyte receptor B	amide binding amyloid-beta binding binding peptide binding protein binding signaling receptor binding Toll-like receptor binding hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity protein-containing complex binding identical protein binding amide binding amyloid-beta binding binding peptide binding protein binding signaling receptor binding Toll-like receptor binding hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity protein-containing complex binding identical protein binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity glycosaminoglycan binding carbohydrate derivative binding peptidoglycan binding lipid binding lipopolysaccharide binding triacyl lipopeptide binding lipopeptide binding pattern recognition receptor activity NADP+ nucleosidase activity lipopolysaccharide immune receptor activity	behavior multicellular organismal process system process learning learning or memory nervous system process cognition regulation of defense response regulation of biological process response to stimulus regulation of response to external stimulus defense response biological regulation positive regulation of biological process behavior multicellular organismal process system process learning learning or memory nervous system process cognition regulation of defense response regulation of biological process response to stimulus regulation of response to external stimulus defense response biological regulation positive regulation of biological process response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response response to organic substance response to ketone response to lipid response to endogenous stimulus response to progesterone response to oxygen-containing compound response to hormone response to steroid hormone response to chemical response to organic cyclic compound regulation of cellular process cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization transport matrix metallopeptidase secretion positive regulation of matrix metallopeptidase secretion positive regulation of establishment of protein localization positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport localization secretion by cell regulation of secretion by cell positive regulation of secretion cellular macromolecule localization regulation of matrix metallopeptidase secretion secretion regulation of transport organic substance transport establishment of protein localization to extracellular region regulation of establishment of protein localization export from cell regulation of protein transport protein secretion establishment of localization positive regulation of protein secretion regulation of protein secretion regulation of secretion positive regulation of transport protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization apoptotic process cell death programmed cell death biological process involved in interspecies interaction between organisms immune response response to other organism defense response to symbiont response to biotic stimulus immune system process defense response to other organism innate immune response response to external biotic stimulus response to toxic substance positive regulation of interleukin-8 production cytokine production regulation of cytokine production regulation of multicellular organismal process interleukin-8 production positive regulation of multicellular organismal process positive regulation of cytokine production regulation of interleukin-8 production regulation of chemokine production chemokine production positive regulation of chemokine production positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of molecular function organic cyclic compound metabolic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of DNA-templated transcription cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction signaling regulation of signal transduction cell communication positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway regulation of cell communication positive regulation of signaling cellular response to lipoteichoic acid response to lipoteichoic acid cellular response to molecule of bacterial origin cellular response to oxygen-containing compound cellular response to biotic stimulus cellular response to chemical stimulus response to bacterium response to molecule of bacterial origin interleukin-10 production regulation of interleukin-10 production positive regulation of interleukin-10 production response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus defense response to virus response to virus transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process carboxylic acid metabolic process small molecule metabolic process organic acid metabolic process cell activation myeloid leukocyte activation leukocyte activation macrophage activation leukocyte activation involved in inflammatory response microglial cell activation glial cell activation neuroinflammatory response cellular response to bacterial lipoprotein response to bacterial lipoprotein response to bacterial lipopeptide cellular response to bacterial lipopeptide cellular response to triacyl bacterial lipopeptide response to triacyl bacterial lipopeptide cellular developmental process cellular component assembly involved in morphogenesis cell development glial cell development myelin assembly cellular component organization cellular component biogenesis multicellular organism development neurogenesis cellular anatomical entity morphogenesis cellular component assembly gliogenesis axon ensheathment ensheathment of neurons cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process oligodendrocyte development central nervous system myelination nervous system development central nervous system myelin formation myelination anatomical structure morphogenesis axon ensheathment in central nervous system central nervous system development oligodendrocyte differentiation glial cell differentiation anatomical structure formation involved in morphogenesis myeloid leukocyte differentiation mononuclear cell differentiation microglia differentiation hemopoiesis macrophage differentiation microglia development myeloid cell differentiation myeloid cell development leukocyte differentiation nitric oxide metabolic process reactive nitrogen species metabolic process response to diacyl bacterial lipopeptide cellular response to diacyl bacterial lipopeptide interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production regulation of cellular component organization regulation of developmental process negative regulation of biological process regulation of nervous system development negative regulation of cell junction assembly cell junction assembly negative regulation of cellular process negative regulation of nervous system development regulation of synapse structure or activity synapse organization regulation of biological quality regulation of synapse assembly regulation of multicellular organismal development negative regulation of cellular component organization negative regulation of developmental process negative regulation of synapse organization regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization cell junction organization negative regulation of multicellular organismal process synapse assembly negative regulation of synapse assembly detection of external biotic stimulus detection of molecule of bacterial origin detection of other organism detection of bacterial lipoprotein detection of biotic stimulus detection of bacterium detection of diacyl bacterial lipopeptide detection of stimulus detection of chemical stimulus detection of bacterial lipopeptide regulation of interleukin-12 production interleukin-12 production positive regulation of interleukin-12 production positive regulation of response to biotic stimulus immune response-regulating cell surface receptor signaling pathway pattern recognition receptor signaling pathway immune response-activating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process cell surface toll-like receptor signaling pathway innate immune response-activating signaling pathway immune response-activating cell surface receptor signaling pathway regulation of innate immune response activation of innate immune response regulation of immune response activation of immune response regulation of response to biotic stimulus innate immune response activating cell surface receptor signaling pathway immune response-regulating signaling pathway toll-like receptor 2 signaling pathway cell surface pattern recognition receptor signaling pathway positive regulation of innate immune response detection of triacyl bacterial lipopeptide regulation of interferon-beta production interferon-beta production positive regulation of type I interferon production type I interferon production positive regulation of interferon-beta production regulation of type I interferon production regulation of nitric-oxide synthase biosynthetic process nitric-oxide synthase biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process response to type II interferon response to cytokine cellular response to type II interferon cellular response to cytokine stimulus cellular response to organic substance negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of response to macrophage colony-stimulating factor positive regulation of response to cytokine stimulus regulation of cellular response to macrophage colony-stimulating factor stimulus positive regulation of response to macrophage colony-stimulating factor response to macrophage colony-stimulating factor cellular response to macrophage colony-stimulating factor stimulus regulation of response to cytokine stimulus positive regulation of cellular response to macrophage colony-stimulating factor stimulus response to organonitrogen compound response to peptide hormone response to insulin response to nitrogen compound toll-like receptor signaling pathway toll-like receptor TLR6:TLR2 signaling pathway intracellular signal transduction intracellular signaling cassette phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process I-kappaB phosphorylation protein phosphorylation organonitrogen compound metabolic process phosphorylation canonical NF-kappaB signal transduction macromolecule modification import into cell negative regulation of transport negative regulation of endocytosis vesicle-mediated transport negative regulation of phagocytosis phagocytosis regulation of endocytosis regulation of phagocytosis regulation of vesicle-mediated transport endocytosis regulation of non-canonical NF-kappaB signal transduction regulation of intracellular signal transduction non-canonical NF-kappaB signal transduction positive regulation of intracellular signal transduction positive regulation of non-canonical NF-kappaB signal transduction response to fatty acid positive regulation of nervous system development regulation of cell differentiation regulation of neurogenesis regulation of gliogenesis positive regulation of gliogenesis regulation of cell development positive regulation of developmental process positive regulation of cell differentiation positive regulation of neurogenesis positive regulation of oligodendrocyte differentiation regulation of glial cell differentiation positive regulation of cell development positive regulation of glial cell differentiation regulation of oligodendrocyte differentiation positive regulation of interleukin-18 production regulation of interleukin-18 production interleukin-18 production regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production defense response to Gram-positive bacterium defense response to bacterium	intracellular anatomical structure cytoplasm cellular anatomical entity protein-containing complex receptor complex membrane-bounded organelle membrane intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle intracellular anatomical structure cytoplasm cellular anatomical entity protein-containing complex receptor complex membrane-bounded organelle membrane intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle endocytic vesicle membrane vesicle organelle membrane endocytic vesicle Golgi apparatus endomembrane system cell periphery plasma membrane protein complex Toll-like receptor 2-Toll-like receptor 6 protein complex plasma membrane plasma membrane signaling receptor complex membrane protein complex cell body cell surface Toll-like receptor 1-Toll-like receptor 2 protein complex membrane microdomain membrane raft secretory granule secretory vesicle secretory granule membrane cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001611	Leucine-rich repeat	Repeat
A, B	IPR017241	Toll-like receptor	Family
A, B	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily	Homologous Superfamily
A, B	IPR000483	Cysteine-rich flanking region, C-terminal	Domain
A, B	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain	Domain
A, B	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A, B	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O60603	rheumatoid arthritis keratitis leprosy cardiomyopathy colorectal cancer cholestasis Inflammation mycobacterium tuberculosis, susceptibility to ovarian cancer pneumonia staphylococcal infection acute kidney failure subependymal giant cell astrocytoma hypereosinophilic syndrome arthritic joint disease rheumatoid arthritis keratitis leprosy cardiomyopathy colorectal cancer cholestasis Inflammation mycobacterium tuberculosis, susceptibility to ovarian cancer pneumonia staphylococcal infection acute kidney failure subependymal giant cell astrocytoma hypereosinophilic syndrome arthritic joint disease interstitial cystitis autoimmune disease breast cancer lung carcinoma periodontitis congestive heart failure psoriasis schizophrenia gastric carcinoma tuberculosis alcohol abuse IgA glomerulonephritis inflammatory bowel disease asthma invasive ductal breast carcinoma bipolar disorder brain injury leprosy, susceptibility to, 3 cancer colorectal carcinoma pilocytic astrocytoma cutaneous lupus erythematosus skin disease staphylococcus aureus infection glioblastoma ulcerative colitis allergic disease inborn carbohydrate metabolic disorder atherosclerosis ischemia reperfusion injury large cell medulloblastoma lung cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.