2YUH

Solution structure of the C-terminal region in human tubulin folding cofactor C

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07986	e2yuhA1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: C-CAP/cofactor C-like (From Topology)	T: C-CAP/cofactor C-like	F: PF07986	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.160.20.70	Mainly Beta	3 Solenoid	Pectate Lyase C-like		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07986	Tubulin binding cofactor C (TBCC)	Tubulin binding cofactor C	Members of this family are involved in the folding pathway of tubulins and form a beta helix structure [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Tubulin-specific chaperone C	cytoskeletal protein binding protein binding binding tubulin binding protein-folding chaperone binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process tubulin complex assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis post-chaperonin tubulin folding pathway	intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle ciliary transition zone non-motile cilium 9+0 non-motile cilium cilium neuron projection plasma membrane bounded cell projection intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle ciliary transition zone non-motile cilium 9+0 non-motile cilium cilium neuron projection plasma membrane bounded cell projection cell projection photoreceptor cell cilium photoreceptor connecting cilium cytoplasm cytosol polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017901	C-CAP/cofactor C-like domain	Domain
A	IPR012945	Tubulin binding cofactor C-like domain	Domain
A	IPR031925	Tubulin-specific chaperone C, N-terminal	Domain
A	IPR006599	CARP motif	Domain
A	IPR016098	Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal	Homologous Superfamily
A	IPR038397	TBCC, N-terminal domain superfamily	Homologous Superfamily
A	IPR027684	Tubulin-specific chaperone C	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q15814	cardiofaciocutaneous syndrome psoriasis medulloblastoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.