2YFL

Crystal Structure of Biphenyl dioxygenase variant RR41 with 2-chloro dibenzofuran

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d2yfla1	All beta proteins	ISP domain	ISP domain	automated matches	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
A	d2yfla2	Alpha and beta proteins (a+b)	TBP-like	Bet v1-like	automated matches	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
C	d2yflc1	All beta proteins	ISP domain	ISP domain	automated matches	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
C	d2yflc2	Alpha and beta proteins (a+b)	TBP-like	Bet v1-like	automated matches	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
E	d2yfle1	All beta proteins	ISP domain	ISP domain	automated matches	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
E	d2yfle2	Alpha and beta proteins (a+b)	TBP-like	Bet v1-like	automated matches	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
G	d2yflg1	All beta proteins	ISP domain	ISP domain	automated matches	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
G	d2yflg2	Alpha and beta proteins (a+b)	TBP-like	Bet v1-like	automated matches	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
I	d2yfli1	All beta proteins	ISP domain	ISP domain	automated matches	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
I	d2yfli2	Alpha and beta proteins (a+b)	TBP-like	Bet v1-like	automated matches	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
K	d2yflk1	All beta proteins	ISP domain	ISP domain	automated matches	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
K	d2yflk2	Alpha and beta proteins (a+b)	TBP-like	Bet v1-like	automated matches	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
B	d2yflb_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ring hydroxylating beta subunit	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
D	d2yfld_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ring hydroxylating beta subunit	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
F	d2yflf_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ring hydroxylating beta subunit	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
H	d2yflh_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ring hydroxylating beta subunit	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
J	d2yflj_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ring hydroxylating beta subunit	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)
L	d2yfll_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Ring hydroxylating beta subunit	automated matches	(Paraburkholderia xenovorans LB400 ) [TaxId: 266265 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	NTF2-like	8074179	3000472	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	NTF2-like	8074179	3000472	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	NTF2-like	8074179	3000472	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	NTF2-like	8074179	3000472	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	NTF2-like	8074179	3000472	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	NTF2-like	8074179	3000472	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e2yflA5	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00848	e2yflA6	A: a+b two layers	X: TBP-like	H: Bet v1-like (From Topology)	T: Bet v1-like	F: PF00848	ECOD (1.6)
A	PF00355	e2yflA3	A: few secondary structure elements	X: Trm112p-like (From Topology)	H: Trm112p-like (From Topology)	T: Trm112p-like	F: PF00355	ECOD (1.6)
C	F_UNCLASSIFIED	e2yflC4	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF00848	e2yflC6	A: a+b two layers	X: TBP-like	H: Bet v1-like (From Topology)	T: Bet v1-like	F: PF00848	ECOD (1.6)
C	PF00355	e2yflC2	A: few secondary structure elements	X: Trm112p-like (From Topology)	H: Trm112p-like (From Topology)	T: Trm112p-like	F: PF00355	ECOD (1.6)
E	F_UNCLASSIFIED	e2yflE8	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF00848	e2yflE9	A: a+b two layers	X: TBP-like	H: Bet v1-like (From Topology)	T: Bet v1-like	F: PF00848	ECOD (1.6)
E	PF00355	e2yflE7	A: few secondary structure elements	X: Trm112p-like (From Topology)	H: Trm112p-like (From Topology)	T: Trm112p-like	F: PF00355	ECOD (1.6)
G	F_UNCLASSIFIED	e2yflG8	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: F_UNCLASSIFIED	ECOD (1.6)
G	PF00848	e2yflG9	A: a+b two layers	X: TBP-like	H: Bet v1-like (From Topology)	T: Bet v1-like	F: PF00848	ECOD (1.6)
G	PF00355	e2yflG7	A: few secondary structure elements	X: Trm112p-like (From Topology)	H: Trm112p-like (From Topology)	T: Trm112p-like	F: PF00355	ECOD (1.6)
I	F_UNCLASSIFIED	e2yflI8	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: F_UNCLASSIFIED	ECOD (1.6)
I	PF00848	e2yflI9	A: a+b two layers	X: TBP-like	H: Bet v1-like (From Topology)	T: Bet v1-like	F: PF00848	ECOD (1.6)
I	PF00355	e2yflI7	A: few secondary structure elements	X: Trm112p-like (From Topology)	H: Trm112p-like (From Topology)	T: Trm112p-like	F: PF00355	ECOD (1.6)
K	F_UNCLASSIFIED	e2yflK8	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: F_UNCLASSIFIED	ECOD (1.6)
K	PF00848	e2yflK9	A: a+b two layers	X: TBP-like	H: Bet v1-like (From Topology)	T: Bet v1-like	F: PF00848	ECOD (1.6)
K	PF00355	e2yflK7	A: few secondary structure elements	X: Trm112p-like (From Topology)	H: Trm112p-like (From Topology)	T: Trm112p-like	F: PF00355	ECOD (1.6)
B	PF00866	e2yflB1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: PF00866	ECOD (1.6)
D	PF00866	e2yflD1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: PF00866	ECOD (1.6)
F	PF00866	e2yflF1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: PF00866	ECOD (1.6)
H	PF00866	e2yflH1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: PF00866	ECOD (1.6)
J	PF00866	e2yflJ1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: PF00866	ECOD (1.6)
L	PF00866	e2yflL1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: PF00866	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.380.10	Alpha Beta	Alpha-Beta Complex	Naphthalene 1,2-dioxygenase Alpha Subunit	Chain A, domain 1	CATH (4.3.0)
A	2.102.10.10	Mainly Beta	3-layer Sandwich	Rieske Iron-sulfur Protein	Rieske [2Fe-2S] iron-sulphur domain	CATH (4.3.0)
C	3.90.380.10	Alpha Beta	Alpha-Beta Complex	Naphthalene 1,2-dioxygenase Alpha Subunit	Chain A, domain 1	CATH (4.3.0)
C	2.102.10.10	Mainly Beta	3-layer Sandwich	Rieske Iron-sulfur Protein	Rieske [2Fe-2S] iron-sulphur domain	CATH (4.3.0)
E	3.90.380.10	Alpha Beta	Alpha-Beta Complex	Naphthalene 1,2-dioxygenase Alpha Subunit	Chain A, domain 1	CATH (4.3.0)
E	2.102.10.10	Mainly Beta	3-layer Sandwich	Rieske Iron-sulfur Protein	Rieske [2Fe-2S] iron-sulphur domain	CATH (4.3.0)
G	3.90.380.10	Alpha Beta	Alpha-Beta Complex	Naphthalene 1,2-dioxygenase Alpha Subunit	Chain A, domain 1	CATH (4.3.0)
G	2.102.10.10	Mainly Beta	3-layer Sandwich	Rieske Iron-sulfur Protein	Rieske [2Fe-2S] iron-sulphur domain	CATH (4.3.0)
I	3.90.380.10	Alpha Beta	Alpha-Beta Complex	Naphthalene 1,2-dioxygenase Alpha Subunit	Chain A, domain 1	CATH (4.3.0)
I	2.102.10.10	Mainly Beta	3-layer Sandwich	Rieske Iron-sulfur Protein	Rieske [2Fe-2S] iron-sulphur domain	CATH (4.3.0)
K	3.90.380.10	Alpha Beta	Alpha-Beta Complex	Naphthalene 1,2-dioxygenase Alpha Subunit	Chain A, domain 1	CATH (4.3.0)
K	2.102.10.10	Mainly Beta	3-layer Sandwich	Rieske Iron-sulfur Protein	Rieske [2Fe-2S] iron-sulphur domain	CATH (4.3.0)
B	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
D	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
F	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
H	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
J	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
L	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G, I A, C, E, G, I, K	PF00848	Ring hydroxylating alpha subunit (catalytic domain) (Ring_hydroxyl_A)	Ring hydroxylating alpha subunit (catalytic domain)	This family is the catalytic domain of aromatic-ring- hydroxylating dioxygenase systems. The active site contains a non-heme ferrous ion coordinated by three ligands.	Domain
A, C, E, G, I A, C, E, G, I, K	PF00355	Rieske [2Fe-2S] domain (Rieske)	Rieske [2Fe-2S] domain	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in ...	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in this motif form a disulphide bridge, which stabilises the protein [4].	Domain
B, D, F, H, J B, D, F, H, J, L	PF00866	Ring hydroxylating beta subunit (Ring_hydroxyl_B)	Ring hydroxylating beta subunit	This subunit has a similar structure to NTF-2 and scytalone dehydratase.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G, I A, C, E, G, I, K	BIPHENYL DIOXYGENASE SUBUNIT ALPHA	iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding biphenyl 2,3-dioxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen catalytic activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor dioxygenase activity cation binding transition metal ion binding iron ion binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding biphenyl 2,3-dioxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen catalytic activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor dioxygenase activity cation binding transition metal ion binding iron ion binding ion binding metal ion binding	-	-
B, D, F, H, J B, D, F, H, J, L	BIPHENYL DIOXYGENASE SUBUNIT BETA	biphenyl 2,3-dioxygenase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen catalytic activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor dioxygenase activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G, I A, C, E, G, I, K	IPR017941	Rieske [2Fe-2S] iron-sulphur domain	Domain
A, C, E, G, I A, C, E, G, I, K	IPR043266	Ring-hydroxylating dioxygenase, alpha subunit NdoB-like, C-terminal	Domain
A, C, E, G, I A, C, E, G, I, K	IPR015881	Aromatic-ring-hydroxylating dioxygenase, 2Fe-2S-binding site	Binding Site
A, C, E, G, I A, C, E, G, I, K	IPR036922	Rieske [2Fe-2S] iron-sulphur domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K	IPR001663	Aromatic-ring-hydroxylating dioxygenase, alpha subunit	Family
A, C, E, G, I A, C, E, G, I, K	IPR015879	Aromatic-ring-hydroxylating dioxygenase, alpha subunit, C-terminal domain	Domain
B, D, F, H, J B, D, F, H, J, L	IPR032710	NTF2-like domain superfamily	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L	IPR000391	Ring-hydroxylating dioxygenase beta subunit	Family

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2YFL

Crystal Structure of Biphenyl dioxygenase variant RR41 with 2-chloro dibenzofuran

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Domain Annotation: ECOD Classification ECOD Database Homepage

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage