2YBT

Crystal structure of human acidic chitinase in complex with bisdionin C

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00704	e2ybtA1	A: a+b two layers	X: FKBP-like	H: Chitinase insertion domain (From Topology)	T: Chitinase insertion domain	F: PF00704	ECOD (1.6)
A	PF00704	e2ybtA2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00704	ECOD (1.6)
B	PF00704	e2ybtB1	A: a+b two layers	X: FKBP-like	H: Chitinase insertion domain (From Topology)	T: Chitinase insertion domain	F: PF00704	ECOD (1.6)
B	PF00704	e2ybtB2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00704	ECOD (1.6)
C	PF00704	e2ybtC1	A: a+b two layers	X: FKBP-like	H: Chitinase insertion domain (From Topology)	T: Chitinase insertion domain	F: PF00704	ECOD (1.6)
C	PF00704	e2ybtC2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00704	ECOD (1.6)
D	PF00704	e2ybtD1	A: a+b two layers	X: FKBP-like	H: Chitinase insertion domain (From Topology)	T: Chitinase insertion domain	F: PF00704	ECOD (1.6)
D	PF00704	e2ybtD2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00704	ECOD (1.6)
E	PF00704	e2ybtE1	A: a+b two layers	X: FKBP-like	H: Chitinase insertion domain (From Topology)	T: Chitinase insertion domain	F: PF00704	ECOD (1.6)
E	PF00704	e2ybtE2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00704	ECOD (1.6)
F	PF00704	e2ybtF1	A: a+b two layers	X: FKBP-like	H: Chitinase insertion domain (From Topology)	T: Chitinase insertion domain	F: PF00704	ECOD (1.6)
F	PF00704	e2ybtF2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF00704	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
A	3.10.50.10	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
B	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
B	3.10.50.10	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
C	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
C	3.10.50.10	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
D	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
D	3.10.50.10	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
E	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
E	3.10.50.10	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
F	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
F	3.10.50.10	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00704	Glycosyl hydrolases family 18 (Glyco_hydro_18)	Glycosyl hydrolases family 18	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	ACIDIC MAMMALIAN CHITINASE	protein binding binding kinase binding enzyme binding chitin binding carbohydrate derivative binding chitinase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity	production of molecular mediator involved in inflammatory response multicellular organismal process response to stimulus defense response response to stress inflammatory response immune system process regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process production of molecular mediator involved in inflammatory response multicellular organismal process response to stimulus defense response response to stress inflammatory response immune system process regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process regulation of cytokine production organic substance biosynthetic process cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of chemokine production regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression chemokine production positive regulation of chemokine production positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process apoptotic process cell death programmed cell death organonitrogen compound catabolic process carbohydrate derivative catabolic process catabolic process organonitrogen compound metabolic process carbohydrate derivative metabolic process chitin metabolic process aminoglycan catabolic process macromolecule catabolic process glucosamine-containing compound catabolic process amino sugar catabolic process aminoglycan metabolic process amino sugar metabolic process organic substance catabolic process chitin catabolic process glucosamine-containing compound metabolic process carbohydrate metabolic process carbohydrate catabolic process primary metabolic process polysaccharide metabolic process polysaccharide catabolic process polysaccharide digestion digestion	extracellular region cellular anatomical entity intracellular anatomical structure cytoplasm extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR011583	Chitinase II	Domain
A, B, C, D, E A, B, C, D, E, F	IPR036508	Chitin binding domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR029070	Chitinase insertion domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR001579	Glycosyl hydrolases family 18 (GH18) active site	Active Site
A, B, C, D, E A, B, C, D, E, F	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR001223	Glycoside hydrolase family 18, catalytic domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR002557	Chitin binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: Q9BZP6	Abortion, Spontaneous gastric carcinoma non-small cell lung carcinoma lung cancer chronic obstructive pulmonary disease lung carcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.